ID   PHCA1_SYNP6             Reviewed;         163 AA.
AC   P00308; Q79DN8;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=C-phycocyanin-1 alpha subunit;
GN   Name=cpcA1; Synonyms=cpcA; OrderedLocusNames=syc0495_c;
OS   Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis
OS   nidulans).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=269084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7524727; DOI=10.1007/bf00039542;
RA   Bhalerao R.P., Lind L.K., Gustafsson P.;
RT   "Cloning of the cpcE and cpcF genes from Synechococcus sp. PCC 6301 and
RT   their inactivation in Synechococcus sp. PCC 7942.";
RL   Plant Mol. Biol. 26:313-326(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27144 / PCC 6301 / SAUG 1402/1;
RX   PubMed=17211581; DOI=10.1007/s11120-006-9122-4;
RA   Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M.,
RA   Kanehisa M., Omata T., Sugiura M., Sugita M.;
RT   "Complete nucleotide sequence of the freshwater unicellular cyanobacterium
RT   Synechococcus elongatus PCC 6301 chromosome: gene content and
RT   organization.";
RL   Photosyn. Res. 93:55-67(2007).
RN   [3]
RP   PROTEIN SEQUENCE OF 2-163.
RA   Walsh R.G., Wingfield P., Glazer A.N., Delange R.J.;
RT   "Amino acid sequence of C-phycocyanin, alpha-subunit, from Synechococcus
RT   6301 (Anacystis nidulans).";
RL   Fed. Proc. 39:1998-1998(1980).
RN   [4]
RP   PROTEIN SEQUENCE OF 75-88, SUBUNIT, AND CHROMOPHORE ATTACHMENT.
RC   STRAIN=ATCC 27144 / PCC 6301 / SAUG 1402/1;
RX   PubMed=412846; DOI=10.1016/s0021-9258(17)38289-3;
RA   Williams V.P., Glazer A.N.;
RT   "Structural studies on phycobiliproteins. I. Bilin-containing peptides of
RT   C-phycocyanin.";
RL   J. Biol. Chem. 253:202-211(1978).
CC   -!- FUNCTION: Light-harvesting photosynthetic bile pigment-protein from the
CC       phycobiliprotein complex (phycobilisome, PBS). Phycocyanin is the major
CC       phycobiliprotein in the PBS rod.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit (PubMed:412846).
CC       The heterodimer further assembles into trimers and the trimers into
CC       hexamers (By similarity). {ECO:0000250|UniProtKB:P13530,
CC       ECO:0000269|PubMed:412846}.
CC   -!- SUBCELLULAR LOCATION: Cellular thylakoid membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}. Note=Part of the phycobilisome rod. {ECO:0000250}.
CC   -!- PTM: Contains one covalently linked bilin chromophore.
CC       {ECO:0000269|PubMed:412846}.
CC   -!- SIMILARITY: Belongs to the phycobiliprotein family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M94218; AAA64527.1; -; Genomic_DNA.
DR   EMBL; AP008231; BAD78685.1; -; Genomic_DNA.
DR   RefSeq; WP_011242807.1; NC_006576.1.
DR   AlphaFoldDB; P00308; -.
DR   SMR; P00308; -.
DR   STRING; 269084.syc0495_c; -.
DR   EnsemblBacteria; BAD78685; BAD78685; syc0495_c.
DR   KEGG; syc:syc0495_c; -.
DR   eggNOG; ENOG502Z85C; Bacteria.
DR   OMA; TTQMQGP; -.
DR   Proteomes; UP000001175; Chromosome.
DR   GO; GO:0030089; C:phycobilisome; IEA:UniProtKB-KW.
DR   GO; GO:0031676; C:plasma membrane-derived thylakoid membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.490.20; -; 1.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012128; Phycobilisome_asu/bsu.
DR   InterPro; IPR038719; Phycobilisome_asu/bsu_sf.
DR   InterPro; IPR006246; Phycocyanin_a.
DR   Pfam; PF00502; Phycobilisome; 1.
DR   PIRSF; PIRSF000081; Phycocyanin; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   TIGRFAMs; TIGR01338; phycocy_alpha; 1.
PE   1: Evidence at protein level;
KW   Antenna complex; Bile pigment; Chromophore; Direct protein sequencing;
KW   Electron transport; Membrane; Photosynthesis; Phycobilisome; Thylakoid;
KW   Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|Ref.3"
FT   CHAIN           2..163
FT                   /note="C-phycocyanin-1 alpha subunit"
FT                   /id="PRO_0000199130"
FT   BINDING         85
FT                   /ligand="(2R,3E)-phycocyanobilin"
FT                   /ligand_id="ChEBI:CHEBI:85275"
FT                   /note="covalent, via 1 link"
FT                   /evidence="ECO:0000269|PubMed:412846"
FT   CONFLICT        54
FT                   /note="N -> D (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        121..122
FT                   /note="KT -> TK (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        158..159
FT                   /note="LI -> IL (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   163 AA;  17288 MW;  3629C5BEE42B350E CRC64;
     MSKTPLTEAV AAADSQGRFL SSTELQVAFG RFRQAASGLA AAKALANNAD SLVNGAANAV
     YSKFPYTTST PGNNFASTPE GKAKCARDIG YYLRIVTYAL VAGGTGPIDE YLLAGLDEIN
     KTFDLAPSWY VEALKYIKAN HGLSGDSRDE ANSYIDYLIN ALS