ID   PHCA_LIMFS              Reviewed;          44 AA.
AC   P84340;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=C-phycocyanin alpha subunit;
DE   Flags: Fragment;
GN   Name=cpcA;
OS   Limnospira fusiformis (Arthrospira fusiformis).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Oscillatoriales;
OC   Sirenicapillariaceae; Limnospira.
OX   NCBI_TaxID=54297;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RA   Harishkumar M., Radha K.S., Sugiki M., Omura S., Maruyama M.;
RT   "Purification and characterization of c-phycocyanin from Spirulina
RT   fusiformis.";
RL   Submitted (DEC-2004) to UniProtKB.
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBUNIT, AND INDUCTION OF A PLASMINOGEN ACTIVATOR IN
RP   MAMMALIAN CELL CULTURE.
RX   PubMed=16920511; DOI=10.1016/j.phymed.2005.09.006;
RA   Madhyastha H.K., Radha K.S., Sugiki M., Omura S., Maruyama M.;
RT   "Purification of c-phycocyanin from Spirulina fusiformis and its effect on
RT   the induction of urokinase-type plasminogen activator from calf pulmonary
RT   endothelial cells.";
RL   Phytomedicine 13:564-569(2006).
CC   -!- FUNCTION: Light-harvesting photosynthetic bile pigment-protein from the
CC       phycobiliprotein complex (phycobilisome, PBS). Phycocyanin is the major
CC       phycobiliprotein in the PBS rod.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit (PubMed:16920511)
CC       (Probable). The heterodimer further assembles into trimers and the
CC       trimers into hexamers (By similarity). {ECO:0000250|UniProtKB:P13530,
CC       ECO:0000269|PubMed:16920511, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cellular thylakoid membrane {ECO:0000269|Ref.1};
CC       Peripheral membrane protein {ECO:0000269|Ref.1}; Cytoplasmic side
CC       {ECO:0000269|Ref.1}. Note=Part of the phycobilisome rod.
CC   -!- PTM: Contains one covalently linked bilin chromophore.
CC       {ECO:0000250|UniProtKB:P13530, ECO:0000305}.
CC   -!- MISCELLANEOUS: In cell culture induces a urokinase-type plasminogen
CC       activator; may therefore be useful in dissolving blood clots.
CC       {ECO:0000269|PubMed:16920511}.
CC   -!- SIMILARITY: Belongs to the phycobiliprotein family. {ECO:0000255}.
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DR   GO; GO:0030089; C:phycobilisome; IEA:UniProtKB-KW.
DR   GO; GO:0031676; C:plasma membrane-derived thylakoid membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.490.20; -; 1.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012128; Phycobilisome_asu/bsu.
DR   InterPro; IPR038719; Phycobilisome_asu/bsu_sf.
DR   Pfam; PF00502; Phycobilisome; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
PE   1: Evidence at protein level;
KW   Antenna complex; Bile pigment; Chromophore; Direct protein sequencing;
KW   Electron transport; Membrane; Photosynthesis; Phycobilisome; Thylakoid;
KW   Transport.
FT   CHAIN           1..>44
FT                   /note="C-phycocyanin alpha subunit"
FT                   /id="PRO_0000199118"
FT   NON_TER         44
SQ   SEQUENCE   44 AA;  4720 MW;  52672017B1F12E18 CRC64;
     MKTPLTEAVS IADSQGRFLS STQIQVLFGR FRQAKAGLXA AKAL