ID   PHCA_MASLA              Reviewed;         163 AA.
AC   P00307;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=C-phycocyanin alpha subunit;
GN   Name=cpcA;
OS   Mastigocladus laminosus (Fischerella sp.).
OC   Bacteria; Cyanobacteria; Nostocales; Hapalosiphonaceae; Mastigocladus.
OX   NCBI_TaxID=83541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kufer W., Hoegner A., Eberlein M., Mayer K., Buchner A., Gottschalk L.;
RT   "Structure and molecular evolution of the gene cluster encoding proteins of
RT   the rod substructure of the phycobilisome from the cyanobacterium
RT   Mastigocadus laminosus.";
RL   Submitted (JAN-1992) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 2-163, SUBUNIT, AND CHROMOPHORE BINDING.
RX   PubMed=103794; DOI=10.1515/bchm2.1978.359.2.1491;
RA   Frank G., Sidler W., Widmer H., Zuber H.;
RT   "The complete amino acid sequence of both subunits of C-phycocyanin from
RT   the cyanobacterium Mastigocladus laminosus.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 359:1491-1507(1978).
CC   -!- FUNCTION: Light-harvesting photosynthetic bile pigment-protein from the
CC       phycobiliprotein complex (phycobilisome, PBS). Phycocyanin is the major
CC       phycobiliprotein in the PBS rod.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit (PubMed:103794).
CC       Heterodimers further assemble into trimers and the trimers into
CC       hexamers (By similarity). {ECO:0000250|UniProtKB:P13530,
CC       ECO:0000269|PubMed:103794}.
CC   -!- SUBCELLULAR LOCATION: Cellular thylakoid membrane; Peripheral membrane
CC       protein; Cytoplasmic side. Note=Part of the phycobilisome rod.
CC   -!- PTM: Contains one covalently linked phycocyanobilin chromophore.
CC       {ECO:0000269|PubMed:103794}.
CC   -!- SIMILARITY: Belongs to the phycobiliprotein family. {ECO:0000305}.
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DR   EMBL; M75599; AAC64650.1; -; Genomic_DNA.
DR   PIR; A00315; CFMWA.
DR   AlphaFoldDB; P00307; -.
DR   SMR; P00307; -.
DR   GO; GO:0030089; C:phycobilisome; IEA:UniProtKB-KW.
DR   GO; GO:0031676; C:plasma membrane-derived thylakoid membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.490.20; -; 1.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012128; Phycobilisome_asu/bsu.
DR   InterPro; IPR038719; Phycobilisome_asu/bsu_sf.
DR   InterPro; IPR006246; Phycocyanin_a.
DR   Pfam; PF00502; Phycobilisome; 1.
DR   PIRSF; PIRSF000081; Phycocyanin; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   TIGRFAMs; TIGR01338; phycocy_alpha; 1.
PE   1: Evidence at protein level;
KW   Antenna complex; Bile pigment; Chromophore; Direct protein sequencing;
KW   Electron transport; Membrane; Photosynthesis; Phycobilisome; Thylakoid;
KW   Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:103794"
FT   CHAIN           2..163
FT                   /note="C-phycocyanin alpha subunit"
FT                   /id="PRO_0000199122"
FT   BINDING         85
FT                   /ligand="(2R,3E)-phycocyanobilin"
FT                   /ligand_id="ChEBI:CHEBI:85275"
FT                   /note="covalent, via 1 link"
FT                   /evidence="ECO:0000269|PubMed:103794"
FT   CONFLICT        67..68
FT                   /note="TT -> LI (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   163 AA;  17524 MW;  EB509EA9BF91ED5D CRC64;
     MVKTPITDAI AAADTQGRFL SNTELQAVNG RYQRAAASLE AARALTANAQ RLIDGAAQAV
     YQKFPYTTQT SGPNYAADAR GKSKCARDIG HYLRIITYSL VAGGTGPLDE YLIAGLNEIN
     DAFELSPSWY IEALKYIKAN HGLSGQAANE ANTYIDYVIN ALS