ID   PHCA_NOSS1              Reviewed;         163 AA.
AC   P07121;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=C-phycocyanin alpha subunit;
GN   Name=cpcA; OrderedLocusNames=alr0529;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3109890; DOI=10.1002/j.1460-2075.1987.tb04833.x;
RA   Belknap W.R., Haselkorn R.;
RT   "Cloning and light regulation of expression of the phycocyanin operon of
RT   the cyanobacterium Anabaena.";
RL   EMBO J. 6:871-884(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11237320; DOI=10.1006/abio.2000.4979;
RA   Cai Y.A., Murphy J.T., Wedemayer G.J., Glazer A.N.;
RT   "Recombinant phycobiliproteins. Recombinant C-phycocyanins equipped with
RT   affinity tags, oligomerization, and biospecific recognition domains.";
RL   Anal. Biochem. 290:186-204(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
RN   [4]
RP   PROTEIN SEQUENCE OF 2-12, SUBUNIT, AND SUBCELLULAR LOCATION.
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=24550276; DOI=10.1073/pnas.1320599111;
RA   Watanabe M., Semchonok D.A., Webber-Birungi M.T., Ehira S., Kondo K.,
RA   Narikawa R., Ohmori M., Boekema E.J., Ikeuchi M.;
RT   "Attachment of phycobilisomes in an antenna-photosystem I supercomplex of
RT   cyanobacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:2512-2517(2014).
CC   -!- FUNCTION: Light-harvesting photosynthetic bile pigment-protein from the
CC       phycobiliprotein complex (phycobilisome, PBS). Phycocyanin is the major
CC       phycobiliprotein in the PBS rod.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain, which further
CC       assembles into trimers and the trimers into hexamers (By similarity).
CC       Part of 2 PBS rod complexes, the conventional PBS rod and a photosystem
CC       I-specific CpcL-PBS rod (PubMed:24550276).
CC       {ECO:0000250|UniProtKB:P13530, ECO:0000269|PubMed:24550276}.
CC   -!- SUBCELLULAR LOCATION: Cellular thylakoid membrane
CC       {ECO:0000269|PubMed:24550276}; Peripheral membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Part of the
CC       phycobilisome rod. {ECO:0000269|PubMed:24550276}.
CC   -!- PTM: Contains one covalently linked phycocyanobilin chromophore.
CC       {ECO:0000250, ECO:0000250|UniProtKB:P13530}.
CC   -!- SIMILARITY: Belongs to the phycobiliprotein family. {ECO:0000305}.
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DR   EMBL; X05239; CAA28863.1; -; Genomic_DNA.
DR   EMBL; AF178757; AAG09317.1; -; Genomic_DNA.
DR   EMBL; BA000019; BAB72487.1; -; Genomic_DNA.
DR   PIR; AH1872; AH1872.
DR   RefSeq; WP_010994705.1; NZ_RSCN01000059.1.
DR   PDB; 7EYD; EM; 3.90 A; B1/B2/B3/B4/B5/B6/B7/BA/D1/D2/D3/D4/D5/D6/D7/DA/F1/F2/F3/F4/F5/F6/F7/FA/H1/H2/H3/H4/H5/H6=1-163.
DR   PDBsum; 7EYD; -.
DR   AlphaFoldDB; P07121; -.
DR   SMR; P07121; -.
DR   STRING; 103690.17129874; -.
DR   EnsemblBacteria; BAB72487; BAB72487; BAB72487.
DR   GeneID; 58725694; -.
DR   KEGG; ana:alr0529; -.
DR   eggNOG; ENOG502Z85C; Bacteria.
DR   OMA; TTQMQGP; -.
DR   OrthoDB; 1513296at2; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0030089; C:phycobilisome; IEA:UniProtKB-KW.
DR   GO; GO:0031676; C:plasma membrane-derived thylakoid membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.490.20; -; 1.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012128; Phycobilisome_asu/bsu.
DR   InterPro; IPR038719; Phycobilisome_asu/bsu_sf.
DR   InterPro; IPR006246; Phycocyanin_a.
DR   Pfam; PF00502; Phycobilisome; 1.
DR   PIRSF; PIRSF000081; Phycocyanin; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   TIGRFAMs; TIGR01338; phycocy_alpha; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antenna complex; Bile pigment; Chromophore;
KW   Direct protein sequencing; Electron transport; Membrane; Photosynthesis;
KW   Phycobilisome; Reference proteome; Thylakoid; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:24550276"
FT   CHAIN           2..163
FT                   /note="C-phycocyanin alpha subunit"
FT                   /id="PRO_0000199117"
FT   BINDING         85
FT                   /ligand="(2R,3E)-phycocyanobilin"
FT                   /ligand_id="ChEBI:CHEBI:85275"
FT                   /note="covalent, via 1 link"
FT                   /evidence="ECO:0000250|UniProtKB:P13530"
SQ   SEQUENCE   163 AA;  17458 MW;  1B2CFE5A8FE64494 CRC64;
     MVKTPITEAI AAADTQGRFL GNTELQSARG RYERAAASLE AARGLTSNAQ RLIDGATQAV
     YQKFPYTTQT PGPQFAADSR GKSKCARDVG HYLRIITYSL VAGGTGPLDE YLIAGLAEIN
     STFDLSPSWY VEALKHIKAN HGLSGQAANE ANTYIDYAIN ALS