ID   PHCA_SYNE7              Reviewed;         163 AA.
AC   P13530; Q31PD6; Q44120;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=C-phycocyanin alpha subunit;
GN   Name=cpcA1; Synonyms=cpcA; OrderedLocusNames=Synpcc7942_1048;
GN   and
GN   Name=cpcA2; OrderedLocusNames=Synpcc7942_1053;
OS   Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans
OS   R2).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=1140;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3036657; DOI=10.1016/0378-1119(87)90391-x;
RA   Lau R.H., Alvarado-Urbina G., Lau P.C.K.;
RT   "Phycocyanin alpha-subunit gene of Anacystis nidulans R2: cloning,
RT   nucleotide sequencing and expression in Escherichia coli.";
RL   Gene 52:21-29(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2454910; DOI=10.1128/jb.170.7.2961-2970.1988;
RA   Kalla R.S., Lind L.K., Lidholm J., Gustafsson P.;
RT   "Transcriptional organization of the phycocyanin subunit gene clusters of
RT   the cyanobacterium Anacystis nidulans UTEX 625.";
RL   J. Bacteriol. 170:2961-2970(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7942 / FACHB-805;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12.
RX   PubMed=3104880; DOI=10.1093/nar/15.5.2394;
RA   Lau P.C.K., Condie A., Alvarado-Urbina G., Lau R.H.;
RT   "Nucleotide sequence of phycocyanin beta-subunit gene of cyanobacterium
RT   Anacystis nidulans strain R2.";
RL   Nucleic Acids Res. 15:2394-2394(1987).
RN   [5] {ECO:0007744|PDB:4H0M}
RP   X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH PHYCOCYANOBILIN
RP   CHROMOPHORE, PROBABLE REMOVAL OF N-TERMINAL METHIONINE, AND SUBUNIT.
RC   STRAIN=PCC 7942 / FACHB-805;
RX   PubMed=23201474; DOI=10.1016/j.bbabio.2012.11.006;
RA   Marx A., Adir N.;
RT   "Allophycocyanin and phycocyanin crystal structures reveal facets of
RT   phycobilisome assembly.";
RL   Biochim. Biophys. Acta 1827:311-318(2013).
CC   -!- FUNCTION: Light-harvesting photosynthetic bile pigment-protein from the
CC       phycobiliprotein complex (phycobilisome, PBS). Phycocyanin is the major
CC       phycobiliprotein in the PBS rod.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit, which further
CC       assembles into trimers and the trimers into hexamers.
CC       {ECO:0000269|PubMed:23201474, ECO:0007744|PDB:4H0M}.
CC   -!- SUBCELLULAR LOCATION: Cellular thylakoid membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}. Note=Part of the phycobilisome rod. {ECO:0000250}.
CC   -!- PTM: Contains one covalently linked phycocyanobilin chromophore.
CC       {ECO:0000269|PubMed:23201474}.
CC   -!- SIMILARITY: Belongs to the phycobiliprotein family. {ECO:0000305}.
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DR   EMBL; M16325; AAA22051.1; -; Genomic_DNA.
DR   EMBL; M94218; AAA64532.1; -; Genomic_DNA.
DR   EMBL; CP000100; ABB57083.1; -; Genomic_DNA.
DR   EMBL; CP000100; ABB57078.1; -; Genomic_DNA.
DR   EMBL; X04916; CAA28586.1; -; Genomic_DNA.
DR   RefSeq; WP_011242807.1; NC_007604.1.
DR   PDB; 4H0M; X-ray; 2.20 A; A/C/E/G/I/K/M/O/Q/S/U/W=1-163.
DR   PDB; 7D6W; X-ray; 2.15 A; A/C/E/G/I/K=2-163.
DR   PDBsum; 4H0M; -.
DR   PDBsum; 7D6W; -.
DR   AlphaFoldDB; P13530; -.
DR   SMR; P13530; -.
DR   STRING; 1140.Synpcc7942_1048; -.
DR   PRIDE; P13530; -.
DR   EnsemblBacteria; ABB57078; ABB57078; Synpcc7942_1048.
DR   EnsemblBacteria; ABB57083; ABB57083; Synpcc7942_1053.
DR   KEGG; syf:Synpcc7942_1048; -.
DR   KEGG; syf:Synpcc7942_1053; -.
DR   eggNOG; ENOG502Z85C; Bacteria.
DR   HOGENOM; CLU_104219_2_0_3; -.
DR   OMA; TTQMQGP; -.
DR   OrthoDB; 1513296at2; -.
DR   BioCyc; MetaCyc:SYNPCC7942_1048-MON; -.
DR   BioCyc; SYNEL:SYNPCC7942_1048-MON; -.
DR   GO; GO:0030089; C:phycobilisome; IEA:UniProtKB-KW.
DR   GO; GO:0031676; C:plasma membrane-derived thylakoid membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.490.20; -; 1.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012128; Phycobilisome_asu/bsu.
DR   InterPro; IPR038719; Phycobilisome_asu/bsu_sf.
DR   InterPro; IPR006246; Phycocyanin_a.
DR   Pfam; PF00502; Phycobilisome; 1.
DR   PIRSF; PIRSF000081; Phycocyanin; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   TIGRFAMs; TIGR01338; phycocy_alpha; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antenna complex; Bile pigment; Chromophore;
KW   Electron transport; Membrane; Photosynthesis; Phycobilisome; Thylakoid;
KW   Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000305|PubMed:23201474"
FT   CHAIN           2..163
FT                   /note="C-phycocyanin alpha subunit"
FT                   /id="PRO_0000199132"
FT   BINDING         85
FT                   /ligand="(2R,3E)-phycocyanobilin"
FT                   /ligand_id="ChEBI:CHEBI:85275"
FT                   /note="covalent, via 1 link"
FT                   /evidence="ECO:0000269|PubMed:23201474,
FT                   ECO:0007744|PDB:4H0M"
FT   HELIX           5..16
FT                   /evidence="ECO:0007829|PDB:4H0M"
FT   HELIX           22..47
FT                   /evidence="ECO:0007829|PDB:4H0M"
FT   HELIX           49..63
FT                   /evidence="ECO:0007829|PDB:4H0M"
FT   HELIX           66..69
FT                   /evidence="ECO:0007829|PDB:4H0M"
FT   HELIX           79..102
FT                   /evidence="ECO:0007829|PDB:4H0M"
FT   HELIX           106..111
FT                   /evidence="ECO:0007829|PDB:4H0M"
FT   TURN            112..115
FT                   /evidence="ECO:0007829|PDB:4H0M"
FT   HELIX           116..122
FT                   /evidence="ECO:0007829|PDB:4H0M"
FT   HELIX           127..140
FT                   /evidence="ECO:0007829|PDB:4H0M"
FT   HELIX           145..161
FT                   /evidence="ECO:0007829|PDB:4H0M"
SQ   SEQUENCE   163 AA;  17288 MW;  3629C5BEE42B350E CRC64;
     MSKTPLTEAV AAADSQGRFL SSTELQVAFG RFRQAASGLA AAKALANNAD SLVNGAANAV
     YSKFPYTTST PGNNFASTPE GKAKCARDIG YYLRIVTYAL VAGGTGPIDE YLLAGLDEIN
     KTFDLAPSWY VEALKYIKAN HGLSGDSRDE ANSYIDYLIN ALS