ID   PHCA_SYNP2              Reviewed;         162 AA.
AC   P03943; B1XIT9; Q44172;
DT   23-OCT-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-1986, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=C-phycocyanin subunit alpha;
DE            Short=alpha-PC;
GN   Name=cpcA; OrderedLocusNames=SYNPCC7002_A2210;
OS   Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum
OS   quadruplicatum).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=32049;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 27264 / PCC 7002 / PR-6;
RX   PubMed=6096868; DOI=10.1073/pnas.81.24.7946;
RA   de Lorimier R., Bryant D.A., Porter R.D., Liu W.-Y., Jay E.,
RA   Stevens S.E. Jr.;
RT   "Genes for the alpha and beta subunits of phycocyanin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:7946-7950(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 27264 / PCC 7002 / PR-6;
RX   PubMed=6438628; DOI=10.1073/pnas.81.22.6983;
RA   Pilot T.J., Fox J.L.;
RT   "Cloning and sequencing of the genes encoding the alpha and beta subunits
RT   of C-phycocyanin from the cyanobacterium Agmenellum quadruplicatum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:6983-6987(1984).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27264 / PCC 7002 / PR-6;
RA   Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T.,
RA   Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J.,
RA   Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.;
RT   "Complete sequence of Synechococcus sp. PCC 7002.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 149-162.
RC   STRAIN=PR6009;
RX   PubMed=2114862; DOI=10.1007/bf00245263;
RA   de Lorimier R., Guglielmi G., Bryant D.A., Stevens S.E. Jr.;
RT   "Structure and mutation of a gene encoding a Mr 33,000 phycocyanin-
RT   associated linker polypeptide.";
RL   Arch. Microbiol. 153:541-549(1990).
RN   [5]
RP   MASS SPECTROMETRY, AND CHROMOPHORE ATTACHMENT.
RC   STRAIN=ATCC 27264 / PCC 7002 / PR-6;
RX   PubMed=18199754; DOI=10.1074/jbc.m708164200;
RA   Shen G., Schluchter W.M., Bryant D.A.;
RT   "Biogenesis of phycobiliproteins: I. cpcS-I and cpcU mutants of the
RT   cyanobacterium Synechococcus sp. PCC 7002 define a heterodimeric
RT   phyococyanobilin lyase specific for beta-phycocyanin and allophycocyanin
RT   subunits.";
RL   J. Biol. Chem. 283:7503-7512(2008).
CC   -!- FUNCTION: Light-harvesting photosynthetic bile pigment-protein from the
CC       phycobiliprotein complex (phycobilisome, PBS). Phycocyanin is the major
CC       phycobiliprotein in the PBS rod.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit, which further
CC       assembles into trimers and the trimers into hexamers.
CC       {ECO:0000250|UniProtKB:P13530}.
CC   -!- SUBCELLULAR LOCATION: Cellular thylakoid membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}. Note=Part of the phycobilisome rod. {ECO:0000250}.
CC   -!- PTM: Contains one covalently linked phycocyanobilin chromophore.
CC       {ECO:0000269|PubMed:18199754}.
CC   -!- MASS SPECTROMETRY: Mass=18208; Method=Electrospray; Note=The measured
CC       mass is that of the protein plus one covalently linked phycocyanobilin
CC       chromophore.; Evidence={ECO:0000269|PubMed:18199754};
CC   -!- SIMILARITY: Belongs to the phycobiliprotein family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; K02660; AAB05344.1; -; Genomic_DNA.
DR   EMBL; K02659; AAB05342.1; -; Genomic_DNA.
DR   EMBL; CP000951; ACB00191.1; -; Genomic_DNA.
DR   EMBL; X81868; CAA57456.1; -; mRNA.
DR   PIR; A94024; CFYCAA.
DR   RefSeq; WP_012307809.1; NC_010475.1.
DR   PDB; 7EXT; EM; 3.50 A; B1/B2/B4/B5/B6/B8/D1/D2/D4/D5/D6/D8/F1/F2/F4/F5/F6/F8/H1/H2/H4/H5/H6/H8/J1/J2/J4/J5/J6/J8=1-162.
DR   PDBsum; 7EXT; -.
DR   AlphaFoldDB; P03943; -.
DR   SMR; P03943; -.
DR   STRING; 32049.SYNPCC7002_A2210; -.
DR   EnsemblBacteria; ACB00191; ACB00191; SYNPCC7002_A2210.
DR   KEGG; syp:SYNPCC7002_A2210; -.
DR   eggNOG; ENOG502Z85C; Bacteria.
DR   HOGENOM; CLU_104219_2_0_3; -.
DR   OMA; TTQMQGP; -.
DR   Proteomes; UP000001688; Chromosome.
DR   GO; GO:0030089; C:phycobilisome; IEA:UniProtKB-KW.
DR   GO; GO:0031676; C:plasma membrane-derived thylakoid membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.490.20; -; 1.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012128; Phycobilisome_asu/bsu.
DR   InterPro; IPR038719; Phycobilisome_asu/bsu_sf.
DR   InterPro; IPR006246; Phycocyanin_a.
DR   Pfam; PF00502; Phycobilisome; 1.
DR   PIRSF; PIRSF000081; Phycocyanin; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   TIGRFAMs; TIGR01338; phycocy_alpha; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antenna complex; Bile pigment; Chromophore;
KW   Electron transport; Membrane; Photosynthesis; Phycobilisome;
KW   Reference proteome; Thylakoid; Transport.
FT   CHAIN           1..162
FT                   /note="C-phycocyanin subunit alpha"
FT                   /id="PRO_0000199129"
FT   BINDING         84
FT                   /ligand="(2R,3E)-phycocyanobilin"
FT                   /ligand_id="ChEBI:CHEBI:85275"
FT                   /note="covalent, via 1 link"
FT                   /evidence="ECO:0000305|PubMed:18199754"
SQ   SEQUENCE   162 AA;  17622 MW;  840D7777CD617764 CRC64;
     MKTPLTEAVA LADSQGRFLS NTELQYLYGR LRQGAFALEA AQTLTAKADT LVNGAAQAVY
     SKFPYTTSTP GNNFAADQRG KDKCARDIGY YLRMVTYCLV AGGTGPMDEY LIAGVDEINR
     TFDLSPSWYV EALKHIKANH GLTGDAATET NNYIDYAINA LS