ID   A4_VARV                 Reviewed;         271 AA.
AC   P0DOP2; P33832;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 10.
DE   RecName: Full=39kDa core protein;
DE            Short=p39;
DE   AltName: Full=Protein A4;
GN   ORFNames=A4L;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
CC   -!- FUNCTION: Component of the virion core. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with P4A/A10 and its cleaved form 4A. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Localizes between the
CC       core and the membrane; might surround the outer core wall like a
CC       palisade (spikes). {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: Its phosphorylation state is regulated by the F10 kinase and the
CC       H1 phosphatase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A4 family. {ECO:0000305}.
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DR   EMBL; L22579; AAA60856.1; -; Genomic_DNA.
DR   PIR; T28546; T28546.
DR   RefSeq; NP_042152.1; NC_001611.1.
DR   SMR; P0DOP2; -.
DR   GeneID; 1486531; -.
DR   KEGG; vg:1486531; -.
DR   Proteomes; UP000119805; Genome.
DR   InterPro; IPR010396; Orthopox_A5.
DR   Pfam; PF06193; Orthopox_A5L; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Virion.
FT   CHAIN           1..271
FT                   /note="39kDa core protein"
FT                   /id="PRO_0000448149"
FT   REGION          80..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          140..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   271 AA;  30060 MW;  26252594A34560FA CRC64;
     MDFFNKFSQG LAESSTPKSS IYYSEEKDLD IKKDEAIEIG LKSQESYYQR QLREQLARDN
     MMAASRQPIQ PLQPTIHITP LQVPTPAPTP KPRQQQTNTS SDMSNLFDWL SADDNTQPSS
     LLPALTPINA VQDIISKFNK DQKTTTTPST QPSQTLPTTT CTQQSDGSIS CTTPTVTPPQ
     PPIVATVCTP TPTGGTVCTT AQQNPNPGAT SQQNLDNMAL KDLMSSVEKD MRQLQAETND
     LVTNVYDARE YTRRAIDQIL QLVKGFERFQ K