ID   PHCY2_HOMAM             Reviewed;         681 AA.
AC   Q6KF81;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Pseudohemocyanin-2;
DE   Flags: Precursor; Fragment;
GN   Name=phc-2 {ECO:0000312|EMBL:CAB38043.1};
OS   Homarus americanus (American lobster).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea;
OC   Nephropoidea; Nephropidae; Homarus.
OX   NCBI_TaxID=6706;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAB38043.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-33, SUBUNIT, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Hemolymph {ECO:0000269|PubMed:10224079}, and
RC   Thorax {ECO:0000312|EMBL:CAB38043.1};
RX   PubMed=10224079; DOI=10.1074/jbc.274.19.13217;
RA   Burmester T.;
RT   "Identification, molecular cloning and phylogenetic analysis of a non-
RT   respiratory pseudo-hemocyanin of Homarus americanus.";
RL   J. Biol. Chem. 274:13217-13222(1999).
CC   -!- FUNCTION: Does not function as a hemocyanin.
CC       {ECO:0000269|PubMed:10224079}.
CC   -!- SUBUNIT: Hexamer. {ECO:0000269|PubMed:10224079}.
CC   -!- TISSUE SPECIFICITY: Strongly expressed in ovaries. Also expressed in
CC       heart. Not detected in hepatopancreas, gills, connective tissue or
CC       muscle. {ECO:0000269|PubMed:10224079}.
CC   -!- MISCELLANEOUS: Does not bind copper. {ECO:0000269|PubMed:10224079}.
CC   -!- SIMILARITY: Belongs to the tyrosinase family. Hemocyanin subfamily.
CC       {ECO:0000255}.
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DR   EMBL; AJ132142; CAB38043.1; -; mRNA.
DR   AlphaFoldDB; Q6KF81; -.
DR   SMR; Q6KF81; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 1.10.1280.10; -; 1.
DR   Gene3D; 1.20.1370.10; -; 1.
DR   Gene3D; 2.60.40.1520; -; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR013788; Hemocyanin/hexamerin.
DR   InterPro; IPR000896; Hemocyanin/hexamerin_mid_dom.
DR   InterPro; IPR005203; Hemocyanin_C.
DR   InterPro; IPR037020; Hemocyanin_C_sf.
DR   InterPro; IPR005204; Hemocyanin_N.
DR   InterPro; IPR036697; Hemocyanin_N_sf.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11511; PTHR11511; 1.
DR   Pfam; PF03723; Hemocyanin_C; 1.
DR   Pfam; PF00372; Hemocyanin_M; 1.
DR   Pfam; PF03722; Hemocyanin_N; 1.
DR   PRINTS; PR00187; HAEMOCYANIN.
DR   SUPFAM; SSF48050; SSF48050; 1.
DR   SUPFAM; SSF48056; SSF48056; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00210; HEMOCYANIN_2; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Signal.
FT   SIGNAL          <1..21
FT                   /evidence="ECO:0000269|PubMed:10224079"
FT   CHAIN           22..681
FT                   /note="Pseudohemocyanin-2"
FT                   /id="PRO_0000234530"
FT   CARBOHYD        98
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        191
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        228
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        624
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:CAB38043.1"
SQ   SEQUENCE   681 AA;  79222 MW;  44323B74A0C21E69 CRC64;
     VLLCSLVAAT AAWPYFGGFQ RDEPDGVPTA QKQHDINFLL HKLYEPLHEA NLKALEDSFD
     PLAHTANMPD GGVAVNKLMQ EVKTQHLEER HHWFSVFNAT QREEALLLVK VLLQCQDWPT
     AIGNAVYFRK MMNEETYVYA LYTAIKHSPL TKHVVLPPLY EIMPHFFTSS EVIQQAYRAK
     LIEKPGRFNM NFTGTQNNPE HKIAYFGEDI GLSTHYINWH IEYPFWWNET FGYQIERRGE
     NYFWVHHQLV NRFEAERISN HLQKIEKLHW ERNLHEGFDP HTSYKNGNPF PFRHDDIHIE
     DVDKVAEVRD MIVMENRIRD AIAHGYVIDK EGNKVDINNE HGIDILGDII ESCVYNPYNE
     YYGSLHNMGH MMLGHQGDPH AKYYDTPSVL EHYETALRDP AFYKLHKYID DLFRKHKDHL
     KPYSQEDLLF PGVAVNMIDI DGPLETYFED YEYSLMNAMD DKEEMIWEDS MEISAIIPRL
     RHKDFSFKVN IMNNNDENKL STIRIFAWPH RDVNGVIMPF NEGRWHAIEL DKFQKELIPG
     ENTITRKSSE SSVTVPDVPS LKSLHEQTEA AIAGSSELNL DEFVSATGLP NRLLIPKGNE
     AGVEFKLVVA VTDGVADSVN DEINLTTKFH HYGHHGVYLD KKPHGYPLDR RVPDERLFHE
     IPNFGETIVK VFNRDEHVYH H