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PHD1_YEAST
ID   PHD1_YEAST              Reviewed;         366 AA.
AC   P36093; D6VXP3; Q2VQ88;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=Putative transcription factor PHD1;
GN   Name=PHD1; OrderedLocusNames=YKL043W; ORFNames=YKL256;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S288c / YPH1;
RX   PubMed=8114741; DOI=10.1128/mcb.14.3.2100-2112.1994;
RA   Gimeno C.J., Fink G.R.;
RT   "Induction of pseudohyphal growth by overexpression of PHD1, a
RT   Saccharomyces cerevisiae gene related to transcriptional regulators of
RT   fungal development.";
RL   Mol. Cell. Biol. 14:2100-2112(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8154189; DOI=10.1002/yea.320091212;
RA   Purnelle B., Tettelin H., van Dyck L., Skala J., Goffeau A.;
RT   "The sequence of a 17.5 kb DNA fragment on the left arm of yeast chromosome
RT   XI identifies the protein kinase gene ELM1, the DNA primase gene PRI2, a
RT   new gene encoding a putative histone and seven new open reading frames.";
RL   Yeast 9:1379-1384(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8196765; DOI=10.1038/369371a0;
RA   Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA   Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA   Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA   Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA   Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA   Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA   Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA   Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA   Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA   Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA   Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA   Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA   Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA   Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA   Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA   Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA   Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA   Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA   Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA   van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA   von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA   Becker I., Mewes H.-W.;
RT   "Complete DNA sequence of yeast chromosome XI.";
RL   Nature 369:371-378(1994).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 76625 / YPH499, YPS396, YPS400, YPS598, YPS600, YPS602, YPS604,
RC   YPS606, YPS608, and YPS610;
RA   Townsend J.P., Aa E., Taylor J.W.;
RT   "Population structure of the wine yeast Saccharomyces cerevisiae.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: Putative transcription factor that functions in pseudohyphal
CC       growth.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- MISCELLANEOUS: Present with 1420 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the EFG1/PHD1/stuA family. {ECO:0000305}.
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DR   EMBL; U05241; AAA18358.1; -; Unassigned_DNA.
DR   EMBL; X71621; CAA50629.1; -; Genomic_DNA.
DR   EMBL; Z28043; CAA81878.1; -; Genomic_DNA.
DR   EMBL; AY557923; AAS56249.1; -; Genomic_DNA.
DR   EMBL; AY949939; AAY27341.1; -; Genomic_DNA.
DR   EMBL; AY949940; AAY27342.1; -; Genomic_DNA.
DR   EMBL; AY949941; AAY27343.1; -; Genomic_DNA.
DR   EMBL; AY949942; AAY27344.1; -; Genomic_DNA.
DR   EMBL; AY949943; AAY27345.1; -; Genomic_DNA.
DR   EMBL; AY949944; AAY27346.1; -; Genomic_DNA.
DR   EMBL; AY949945; AAY27347.1; -; Genomic_DNA.
DR   EMBL; AY949946; AAY27348.1; -; Genomic_DNA.
DR   EMBL; AY949947; AAY27349.1; -; Genomic_DNA.
DR   EMBL; AY949948; AAY27350.1; -; Genomic_DNA.
DR   EMBL; BK006944; DAA09113.1; -; Genomic_DNA.
DR   PIR; S37864; S37864.
DR   RefSeq; NP_012881.1; NM_001179609.1.
DR   AlphaFoldDB; P36093; -.
DR   SMR; P36093; -.
DR   BioGRID; 34089; 101.
DR   DIP; DIP-4868N; -.
DR   IntAct; P36093; 2.
DR   STRING; 4932.YKL043W; -.
DR   iPTMnet; P36093; -.
DR   MaxQB; P36093; -.
DR   PaxDb; P36093; -.
DR   PRIDE; P36093; -.
DR   EnsemblFungi; YKL043W_mRNA; YKL043W; YKL043W.
DR   GeneID; 853823; -.
DR   KEGG; sce:YKL043W; -.
DR   SGD; S000001526; PHD1.
DR   VEuPathDB; FungiDB:YKL043W; -.
DR   eggNOG; ENOG502QW2C; Eukaryota.
DR   GeneTree; ENSGT00940000176596; -.
DR   HOGENOM; CLU_756942_0_0_1; -.
DR   InParanoid; P36093; -.
DR   OMA; AVPFPTX; -.
DR   BioCyc; YEAST:G3O-31844-MON; -.
DR   PRO; PR:P36093; -.
DR   Proteomes; UP000002311; Chromosome XI.
DR   RNAct; P36093; protein.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:SGD.
DR   GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR   GO; GO:2000222; P:positive regulation of pseudohyphal growth; IMP:SGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:SGD.
DR   Gene3D; 3.10.260.10; -; 1.
DR   InterPro; IPR029790; EFG1/Phd1/StuA.
DR   InterPro; IPR036887; HTH_APSES_sf.
DR   InterPro; IPR018004; KilA_N/APSES_HTH.
DR   InterPro; IPR003163; Tscrpt_reg_HTH_APSES-type.
DR   PANTHER; PTHR47792; PTHR47792; 1.
DR   Pfam; PF04383; KilA-N; 1.
DR   SMART; SM01252; KilA-N; 1.
DR   SUPFAM; SSF54616; SSF54616; 1.
DR   PROSITE; PS51299; HTH_APSES; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..366
FT                   /note="Putative transcription factor PHD1"
FT                   /id="PRO_0000058377"
FT   DOMAIN          186..292
FT                   /note="HTH APSES-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT   DNA_BIND        220..241
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT   REGION          294..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..311
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   366 AA;  40646 MW;  22B6FA0D505D8654 CRC64;
     MYHVPEMRLH YPLVNTQSNA AITPTRSYDN TLPSFNELSH QSTINLPFVQ RETPNAYANV
     AQLATSPTQA KSGYYCRYYA VPFPTYPQQP QSPYQQAVLP YATIPNSNFQ PSSFPVMAVM
     PPEVQFDGSF LNTLHPHTEL PPIIQNTNDT SVARPNNLKS IAAASPTVTA TTRTPGVSST
     SVLKPRVITT MWEDENTICY QVEANGISVV RRADNNMING TKLLNVTKMT RGRRDGILRS
     EKVREVVKIG SMHLKGVWIP FERAYILAQR EQILDHLYPL FVKDIESIVD ARKPSNKASL
     TPKSSPAPIK QEPSDNKHEI ATEIKPKSID ALSNGASTQG AGELPHLKIN HIDTEAQTSR
     AKNELS
 
 
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