ID   PHDT_NOCSK              Reviewed;         473 AA.
AC   O24723;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable 1-hydroxy-2-naphthoate transporter;
OS   Nocardioides sp. (strain KP7).
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=102632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9335300; DOI=10.1128/jb.179.20.6488-6494.1997;
RA   Iwabuchi T., Harayama S.;
RT   "Biochemical and genetic characterization of 2-carboxybenzaldehyde
RT   dehydrogenase, an enzyme involved in phenanthrene degradation by
RT   Nocardioides sp. strain KP7.";
RL   J. Bacteriol. 179:6488-6494(1997).
CC   -!- FUNCTION: Probably involved in the transport of 1-hydroxy-2-naphthoate.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Aromatic
CC       acid:H(+) symporter (AAHS) (TC 2.A.1.15) family. {ECO:0000305}.
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DR   EMBL; AB000735; BAA23264.1; -; Genomic_DNA.
DR   AlphaFoldDB; O24723; -.
DR   SMR; O24723; -.
DR   TCDB; 2.A.1.15.8; the major facilitator superfamily (mfs).
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..473
FT                   /note="Probable 1-hydroxy-2-naphthoate transporter"
FT                   /id="PRO_0000050322"
FT   TOPO_DOM        1..25
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..59
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..91
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        113..121
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        143..153
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        175..180
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        202..263
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        285..304
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        326..330
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        352..354
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        376..398
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        399..418
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        419..421
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..444
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        445..473
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   473 AA;  49110 MW;  D6D765D376260D8A CRC64;
     MNTSPGAPTG VRAFVDSQPI GRRQRIIVLM VFLIMVADGM DITLASHLFP PVIRDWGVPV
     SAVTLVVSLG VVAMAIGALV SGPVADRWGR KGVTVVGFVL FCLATAGLGL TGDIHSFAAL
     RIISCFGLGA VMPVALTIVA DWMPKARRAQ MVSIAFAGVG VGSIIGAYLA AAVIPTLGWQ
     VMVLIAGLAP LIILPFFVAL VPEPAIISVR RGIPEARIRS ALALVAPDRD IAGVDLTRAG
     LTLGAGEVRA KALFAEILCR PLLGVTLLIW GVFFVVQGSG LLVLQYMPML LQAPAPGLST
     VESGLIVAMY GWGALIGQLT IAFILKRFDR FIALAAFIFW SVVGLLIVAA FGTGFGFFGY
     FTLLFAIGLS LPATAAAMQS VTTLAYEEEF RATGMGSAGF AGRLGTLTYG ALGGTLIGAG
     FGITTVSLVL AAPLAVSIGL VFSLRALSRR AGIAPEPHQI TPGNEVDDAH VST