PHE1_ARATH
ID PHE1_ARATH Reviewed; 279 AA.
AC O80805; Q84JV4; Q84JW5; Q84VN9; Q84VP0; Q84VP1;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=MADS-box transcription factor PHERES 1;
DE AltName: Full=Agamous-like MADS-box protein AGL37;
GN Name=PHE1; Synonyms=AGL37; OrderedLocusNames=At1g65330; ORFNames=T8F5.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 14-230, AND VARIANTS ILE-76; GLN-128;
RP THR-169 AND ASP-230.
RC STRAIN=cv. Bla-1, cv. Bs-1, cv. Chi-1, cv. Co-1, cv. Cvi-0, cv. Gr-3,
RC cv. Ita-0, cv. Kas-1, and cv. Lisse-2;
RX PubMed=12663546; DOI=10.1093/genetics/163.3.1083;
RA Shepard K.A., Purugganan M.D.;
RT "Molecular population genetics of the Arabidopsis CLAVATA2 region: the
RT genomic scale of variation and selection in a selfing species.";
RL Genetics 163:1083-1095(2003).
RN [4]
RP FUNCTION, INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=12815071; DOI=10.1101/gad.257403;
RA Koehler C., Hennig L., Spillane C., Pien S., Gruissem W., Grossniklaus U.;
RT "The Polycomb-group protein MEDEA regulates seed development by controlling
RT expression of the MADS-box gene PHERES1.";
RL Genes Dev. 17:1540-1553(2003).
RN [5]
RP IMPRINTING, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15619622; DOI=10.1038/ng1495;
RA Koehler C., Page D.R., Gagliardini V., Grossniklaus U.;
RT "The Arabidopsis thaliana MEDEA Polycomb group protein controls expression
RT of PHERES1 by parental imprinting.";
RL Nat. Genet. 37:28-30(2005).
RN [6]
RP INDUCTION.
RX PubMed=16359393; DOI=10.1111/j.1365-313x.2005.02602.x;
RA Li H.-C., Chuang K., Henderson J.T., Rider S.D. Jr., Bai Y., Zhang H.,
RA Fountain M., Gerber J., Ogas J.;
RT "PICKLE acts during germination to repress expression of embryonic
RT traits.";
RL Plant J. 44:1010-1022(2005).
RN [7]
RP INTERACTION WITH AGL62.
RX PubMed=15805477; DOI=10.1105/tpc.105.031831;
RA de Folter S., Immink R.G.H., Kieffer M., Parenicova L., Henz S.R.,
RA Weigel D., Busscher M., Kooiker M., Colombo L., Kater M.M., Davies B.,
RA Angenent G.C.;
RT "Comprehensive interaction map of the Arabidopsis MADS Box transcription
RT factors.";
RL Plant Cell 17:1424-1433(2005).
RN [8]
RP INTERACTION WITH AGL61.
RX PubMed=18713950; DOI=10.1105/tpc.108.058958;
RA Bemer M., Wolters-Arts M., Grossniklaus U., Angenent G.C.;
RT "The MADS domain protein DIANA acts together with AGAMOUS-LIKE80 to specify
RT the central cell in Arabidopsis ovules.";
RL Plant Cell 20:2088-2101(2008).
CC -!- FUNCTION: Probable transcription factor involved in the development of
CC gametophytes and seeds. {ECO:0000269|PubMed:12815071}.
CC -!- SUBUNIT: Interacts with AGL61/DIANA and AGL62.
CC {ECO:0000269|PubMed:15805477, ECO:0000269|PubMed:18713950}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
CC -!- TISSUE SPECIFICITY: Male gametophyte, embryo and endosperm.
CC {ECO:0000269|PubMed:12815071, ECO:0000269|PubMed:15619622}.
CC -!- DEVELOPMENTAL STAGE: Not present in female gametophyte before
CC fertilization. Expressed in pollen tube and at the micropylar pole of
CC pollinated seeds. {ECO:0000269|PubMed:15619622}.
CC -!- INDUCTION: Repressed by MEA, FIS2 and FIE in seeds, and by PKL after
CC germination. {ECO:0000269|PubMed:12815071,
CC ECO:0000269|PubMed:16359393}.
CC -!- MISCELLANEOUS: The PHE1 locus is imprinted in gametophytes. Maternal
CC inherited gene is repressed in female gametophyte, while the paternal
CC inherited gene is expressed in the male gametophyte (pollen tube) and
CC in fertilized seeds. The maternal repression is dependent on MEA, FIS2
CC and FIE proteins, which may modulate the methylation of the maternal
CC locus, and repress its transcription.
CC -!- MISCELLANEOUS: This protein was called 'Pheres' in memory of one of the
CC murdered sons of the mythological 'Medea', as PHERES1 is repressed by
CC MEDEA.
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DR EMBL; AC004512; AAC27144.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34359.1; -; Genomic_DNA.
DR EMBL; AF528574; AAO43311.1; -; Genomic_DNA.
DR EMBL; AF528575; AAO43312.1; -; Genomic_DNA.
DR EMBL; AF528576; AAO43313.1; -; Genomic_DNA.
DR EMBL; AF528577; AAO43314.1; -; Genomic_DNA.
DR EMBL; AF528578; AAO43315.1; -; Genomic_DNA.
DR EMBL; AF528579; AAO43316.1; -; Genomic_DNA.
DR EMBL; AF528580; AAO43317.1; -; Genomic_DNA.
DR EMBL; AF528581; AAO43318.1; -; Genomic_DNA.
DR EMBL; AF528582; AAO43319.1; -; Genomic_DNA.
DR PIR; T02356; T02356.
DR RefSeq; NP_176712.1; NM_105207.2.
DR AlphaFoldDB; O80805; -.
DR SMR; O80805; -.
DR BioGRID; 28062; 7.
DR IntAct; O80805; 8.
DR STRING; 3702.AT1G65330.1; -.
DR PaxDb; O80805; -.
DR PRIDE; O80805; -.
DR ProteomicsDB; 234997; -.
DR EnsemblPlants; AT1G65330.1; AT1G65330.1; AT1G65330.
DR GeneID; 842841; -.
DR Gramene; AT1G65330.1; AT1G65330.1; AT1G65330.
DR KEGG; ath:AT1G65330; -.
DR Araport; AT1G65330; -.
DR TAIR; locus:2206280; AT1G65330.
DR eggNOG; KOG0014; Eukaryota.
DR HOGENOM; CLU_053053_7_1_1; -.
DR InParanoid; O80805; -.
DR OMA; CECKVAG; -.
DR OrthoDB; 1750382at2759; -.
DR PhylomeDB; O80805; -.
DR PRO; PR:O80805; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O80805; baseline and differential.
DR Genevisible; O80805; AT.
DR GO; GO:0005634; C:nucleus; ISS:TAIR.
DR GO; GO:0090406; C:pollen tube; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00266; MADS_SRF_like; 1.
DR Gene3D; 3.40.1810.10; -; 1.
DR InterPro; IPR033897; MADS_SRF-like.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SSF55455; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..279
FT /note="MADS-box transcription factor PHERES 1"
FT /id="PRO_0000233175"
FT DOMAIN 1..60
FT /note="MADS-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT VARIANT 76
FT /note="L -> I (in strain: cv. Bla-1, cv. Bs-1, cv. Ita-0
FT and cv. Kas-1)"
FT /evidence="ECO:0000269|PubMed:12663546"
FT VARIANT 128
FT /note="H -> Q (in strain: cv. Lisse-2)"
FT /evidence="ECO:0000269|PubMed:12663546"
FT VARIANT 169
FT /note="I -> T (in strain: cv. Gr-3)"
FT /evidence="ECO:0000269|PubMed:12663546"
FT VARIANT 230
FT /note="N -> D (in strain: cv. Co-1)"
FT /evidence="ECO:0000269|PubMed:12663546"
SQ SEQUENCE 279 AA; 31953 MW; C054157870B8AE15 CRC64;
MRGKMKLSFI ENDSVRKTTF TKRKKGMLKK FNELVTLCGV DACAVIRSPY NSIQEPWPSR
EGVEEVMSKF MEFSVLDRTK KMVDQETFLR QRIAKETERL QKLRDENRNS QIRDLMFGCL
KGEVDVSHLH GRDLLDLNVF LNKYLNGVIR RVEILKENGE SSSSVPPPIG VAPTVVDASV
PIGFDGRMIQ DQNQNQQEPV QFQYQALYDF YDQIPKKLHD FNMKMNIDPN QSMNLDLNDG
EDEGIPCMDN NNYHPEIDCL ATVTTAPTDV CAPNIINDL
