ID   PHE2_ARATH              Reviewed;         278 AA.
AC   Q7XJK8; O80802;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=MADS-box transcription factor PHERES 2;
DE   AltName: Full=Agamous-like MADS-box protein AGL38;
GN   Name=PHE2; Synonyms=AGL38; OrderedLocusNames=At1g65300; ORFNames=T8F5.8;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Columbia; TISSUE=Silique;
RX   PubMed=12837945; DOI=10.1105/tpc.011544;
RA   Parenicova L., de Folter S., Kieffer M., Horner D.S., Favalli C.,
RA   Busscher J., Cook H.E., Ingram R.M., Kater M.M., Davies B., Angenent G.C.,
RA   Colombo L.;
RT   "Molecular and phylogenetic analyses of the complete MADS-box transcription
RT   factor family in Arabidopsis: new openings to the MADS world.";
RL   Plant Cell 15:1538-1551(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   INDUCTION, AND TISSUE SPECIFICITY.
RX   PubMed=12815071; DOI=10.1101/gad.257403;
RA   Koehler C., Hennig L., Spillane C., Pien S., Gruissem W., Grossniklaus U.;
RT   "The Polycomb-group protein MEDEA regulates seed development by controlling
RT   expression of the MADS-box gene PHERES1.";
RL   Genes Dev. 17:1540-1553(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=16359393; DOI=10.1111/j.1365-313x.2005.02602.x;
RA   Li H.-C., Chuang K., Henderson J.T., Rider S.D. Jr., Bai Y., Zhang H.,
RA   Fountain M., Gerber J., Ogas J.;
RT   "PICKLE acts during germination to repress expression of embryonic
RT   traits.";
RL   Plant J. 44:1010-1022(2005).
RN   [6]
RP   INTERACTION WITH AGL62.
RX   PubMed=15805477; DOI=10.1105/tpc.105.031831;
RA   de Folter S., Immink R.G.H., Kieffer M., Parenicova L., Henz S.R.,
RA   Weigel D., Busscher M., Kooiker M., Colombo L., Kater M.M., Davies B.,
RA   Angenent G.C.;
RT   "Comprehensive interaction map of the Arabidopsis MADS Box transcription
RT   factors.";
RL   Plant Cell 17:1424-1433(2005).
RN   [7]
RP   INTERACTION WITH AGL61.
RX   PubMed=18713950; DOI=10.1105/tpc.108.058958;
RA   Bemer M., Wolters-Arts M., Grossniklaus U., Angenent G.C.;
RT   "The MADS domain protein DIANA acts together with AGAMOUS-LIKE80 to specify
RT   the central cell in Arabidopsis ovules.";
RL   Plant Cell 20:2088-2101(2008).
CC   -!- FUNCTION: Probable transcription factor involved in the development of
CC       gametophytes and seeds.
CC   -!- SUBUNIT: Interacts with AGL61/DIANA and AGL62.
CC       {ECO:0000269|PubMed:15805477, ECO:0000269|PubMed:18713950}.
CC   -!- INTERACTION:
CC       Q7XJK8; Q9FKK2: AGL62; NbExp=4; IntAct=EBI-622157, EBI-622140;
CC       Q7XJK8; A0MFC4; NbExp=3; IntAct=EBI-622157, EBI-15194733;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
CC   -!- TISSUE SPECIFICITY: Male gametophyte, embryo and endosperm.
CC       {ECO:0000269|PubMed:12815071}.
CC   -!- INDUCTION: Repressed by MEA in seeds, and by PKL after germination.
CC       {ECO:0000269|PubMed:12815071, ECO:0000269|PubMed:16359393}.
CC   -!- MISCELLANEOUS: The PHE2 locus is imprinted in gametophytes. Maternal
CC       inherited gene is repressed in female gametophyte, while the paternal
CC       inherited gene is expressed in the male gametophyte (pollen tube) and
CC       in fertilized seeds. The maternal repression is dependent on MEA, which
CC       may modulate the methylation of the maternal locus, and repress its
CC       transcription.
CC   -!- MISCELLANEOUS: This protein was called 'Pheres' in memory of one of the
CC       murdered sons of the mythological 'Medea', as PHERES2 is repressed by
CC       MEDEA.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC27141.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY141245; AAN52809.1; -; mRNA.
DR   EMBL; AC004512; AAC27141.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP002684; AEE34356.1; -; Genomic_DNA.
DR   PIR; T02353; T02353.
DR   RefSeq; NP_176709.2; NM_105204.3.
DR   AlphaFoldDB; Q7XJK8; -.
DR   SMR; Q7XJK8; -.
DR   BioGRID; 28059; 5.
DR   IntAct; Q7XJK8; 6.
DR   STRING; 3702.AT1G65300.1; -.
DR   iPTMnet; Q7XJK8; -.
DR   PaxDb; Q7XJK8; -.
DR   PRIDE; Q7XJK8; -.
DR   EnsemblPlants; AT1G65300.1; AT1G65300.1; AT1G65300.
DR   GeneID; 842838; -.
DR   Gramene; AT1G65300.1; AT1G65300.1; AT1G65300.
DR   KEGG; ath:AT1G65300; -.
DR   Araport; AT1G65300; -.
DR   TAIR; locus:2206325; AT1G65300.
DR   eggNOG; KOG0014; Eukaryota.
DR   HOGENOM; CLU_053053_7_1_1; -.
DR   InParanoid; Q7XJK8; -.
DR   OMA; INACAIV; -.
DR   OrthoDB; 1750382at2759; -.
DR   PhylomeDB; Q7XJK8; -.
DR   PRO; PR:Q7XJK8; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q7XJK8; baseline and differential.
DR   Genevisible; Q7XJK8; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00266; MADS_SRF_like; 1.
DR   Gene3D; 3.40.1810.10; -; 1.
DR   InterPro; IPR033897; MADS_SRF-like.
DR   InterPro; IPR002100; TF_MADSbox.
DR   InterPro; IPR036879; TF_MADSbox_sf.
DR   Pfam; PF00319; SRF-TF; 1.
DR   PRINTS; PR00404; MADSDOMAIN.
DR   SMART; SM00432; MADS; 1.
DR   SUPFAM; SSF55455; SSF55455; 1.
DR   PROSITE; PS50066; MADS_BOX_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..278
FT                   /note="MADS-box transcription factor PHERES 2"
FT                   /id="PRO_0000233176"
FT   DOMAIN          1..60
FT                   /note="MADS-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
SQ   SEQUENCE   278 AA;  31658 MW;  E787DFA95278C641 CRC64;
     MKRKMKLSLI ENSVSRKTTF TKRKKGMTKK LTELVTLCGV EACAVVYSPF NSIPEAWPSR
     EGVEDVVSKF MELSVLDRTK KMVDQETFIS QRIAKEKEQL QKLRDENHNS QIRELMFGCL
     KGETNVYNLD GRDLQDLSLY IDKYLNGLTR RIEILIENGE SSSSLPLPIV ANAAAPVGFD
     GPMFQYHNQN QQKPVQFQYQ ALYDFYDQIP KKIHGFNMNM NKDSNQSMVL DLNQNLNDGE
     DEGIPCMDNN NYHPEIDCLA TVTTAPTDVC APNITNDL