ID   PHF10_XENLA             Reviewed;         506 AA.
AC   Q63ZP1;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=PHD finger protein 10;
GN   Name=phf10;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in transcription activity regulation by chromatin
CC       remodeling in the context of the neural progenitors-specific chromatin
CC       remodeling complex (npBAF complex). May play a role in the
CC       proliferation of neural progenitors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of neural progenitors-specific chromatin remodeling
CC       complex (npBAF complex), a subfamily of ATP-dependent SWI/SNF chromatin
CC       remodeling complexes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SAYP family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-90 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH82869.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC082869; AAH82869.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001088070.2; NM_001094601.1.
DR   AlphaFoldDB; Q63ZP1; -.
DR   SMR; Q63ZP1; -.
DR   DNASU; 494765; -.
DR   GeneID; 494765; -.
DR   KEGG; xla:494765; -.
DR   CTD; 494765; -.
DR   Xenbase; XB-GENE-940964; phf10.S.
DR   OrthoDB; 708781at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 494765; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0071564; C:npBAF complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR038045; PHF10.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR10615:SF174; PTHR10615:SF174; 1.
DR   Pfam; PF00628; PHD; 1.
DR   SMART; SM00249; PHD; 2.
DR   SUPFAM; SSF57903; SSF57903; 2.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 2.
PE   2: Evidence at transcript level;
KW   Metal-binding; Neurogenesis; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..506
FT                   /note="PHD finger protein 10"
FT                   /id="PRO_0000059300"
FT   ZN_FING         387..444
FT                   /note="PHD-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   ZN_FING         446..489
FT                   /note="PHD-type 2; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          90..299
FT                   /note="SAY"
FT   REGION          293..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..47
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        308..322
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..347
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..369
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   506 AA;  57328 MW;  06EE16AD1117787B CRC64;
     MAAVVSAKPL CDSEPAIPAP PSVKEDNSND TKDPEENSND GSQPAKRRRM SGDSTPSCEN
     SNQDFGSSYF PAENVIEYKW PPDETGEYYM LQEQVSEYLG VTSFKRKYPD LERRDLSHKE
     KLYLRELNVI TETQCTLGLT ALRSDEVIDL MIKEYPAKHA EYSVILQEKE RQRITDHYKE
     YSQLQQQNTQ KVEAGKVPEY IKKAAKKAAE FNSNLNRERM EERRAYFDLQ THIIQVPQGK
     YKILPSEMTK VSPYPVSLIP GQFQEYYKRY SPNELRYLPL NTALYEPPLD PLDPELLALD
     SDGDSDEVEE MKSEKKKTKG SSVRLSIDSS SMNMSESDNT QDTQEETPQP RPKVKEKSST
     PRKEGSKRSV LSKSVSGYKP KSIPNAICGI CLKGKDANKK GRSERLIHCS QCDNSGHPSC
     LDMSAELVAV IKKYPWQCME CKTCIICGQP HHEEEMMFCD TCDRGYHTFC VGLGALPSGR
     WICDCCQKVP ATPKKGARKV KNSKEG