PHF11_MOUSE
ID PHF11_MOUSE Reviewed; 337 AA.
AC A6H5X4; Q3U0T6; Q8K2R8;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=PHD finger protein 11;
DE AltName: Full=PHD finger protein 11-like;
DE AltName: Full=PHD finger protein 11D;
GN Name=Phf11; Synonyms=D14Ertd668e, Phf11d, Phf11l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=Czech II; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Positive regulator of Th1-type cytokine gene expression.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with BRCA1 and RELA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A6H5X4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6H5X4-2; Sequence=VSP_038089;
CC Name=3;
CC IsoId=A6H5X4-3; Sequence=VSP_038090;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH30186.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK156583; BAE33765.1; -; mRNA.
DR EMBL; BC030186; AAH30186.1; ALT_INIT; mRNA.
DR EMBL; BC145673; AAI45674.1; -; mRNA.
DR CCDS; CCDS27170.3; -. [A6H5X4-3]
DR RefSeq; NP_950180.3; NM_199015.4. [A6H5X4-3]
DR AlphaFoldDB; A6H5X4; -.
DR SMR; A6H5X4; -.
DR iPTMnet; A6H5X4; -.
DR PhosphoSitePlus; A6H5X4; -.
DR EPD; A6H5X4; -.
DR jPOST; A6H5X4; -.
DR MaxQB; A6H5X4; -.
DR PaxDb; A6H5X4; -.
DR PeptideAtlas; A6H5X4; -.
DR PRIDE; A6H5X4; -.
DR ProteomicsDB; 288189; -. [A6H5X4-1]
DR ProteomicsDB; 288190; -. [A6H5X4-2]
DR ProteomicsDB; 288191; -. [A6H5X4-3]
DR DNASU; 219132; -.
DR Ensembl; ENSMUST00000095157; ENSMUSP00000092779; ENSMUSG00000068245. [A6H5X4-3]
DR Ensembl; ENSMUST00000160425; ENSMUSP00000124578; ENSMUSG00000068245. [A6H5X4-2]
DR Ensembl; ENSMUST00000161031; ENSMUSP00000125181; ENSMUSG00000068245. [A6H5X4-1]
DR GeneID; 219132; -.
DR KEGG; mmu:219132; -.
DR UCSC; uc007uef.2; mouse. [A6H5X4-2]
DR UCSC; uc007ueg.2; mouse. [A6H5X4-1]
DR CTD; 219132; -.
DR MGI; MGI:1277133; Phf11d.
DR VEuPathDB; HostDB:ENSMUSG00000068245; -.
DR eggNOG; KOG1084; Eukaryota.
DR GeneTree; ENSGT00950000182865; -.
DR HOGENOM; CLU_076108_0_0_1; -.
DR InParanoid; A6H5X4; -.
DR OMA; IYKLFCQ; -.
DR PhylomeDB; A6H5X4; -.
DR TreeFam; TF325426; -.
DR BioGRID-ORCS; 219132; 5 hits in 73 CRISPR screens.
DR ChiTaRS; Phf11d; mouse.
DR PRO; PR:A6H5X4; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; A6H5X4; protein.
DR Bgee; ENSMUSG00000068245; Expressed in blastocyst and 65 other tissues.
DR Genevisible; A6H5X4; MM.
DR GO; GO:0031965; C:nuclear membrane; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS51805; EPHD; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..337
FT /note="PHD finger protein 11"
FT /id="PRO_0000385015"
FT ZN_FING 25..61
FT /note="C2HC pre-PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT ZN_FING 91..143
FT /note="PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT REGION 145..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 197..264
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_038089"
FT VAR_SEQ 321..337
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_038090"
FT CONFLICT 125
FT /note="I -> V (in Ref. 2; AAH30186)"
FT /evidence="ECO:0000305"
FT CONFLICT 282
FT /note="Q -> K (in Ref. 2; AAH30186)"
FT /evidence="ECO:0000305"
FT CONFLICT 293
FT /note="S -> T (in Ref. 2; AAH30186)"
FT /evidence="ECO:0000305"
FT CONFLICT 323
FT /note="S -> C (in Ref. 2; AAH30186)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 337 AA; 37728 MW; 0A834D804D6C8BAF CRC64;
MAQETAPPCG PVSRGDSPII EKMEKRTCAL CPEGHEWSQI YFSPSGNIVA HENCLLYSSG
LVECETLDLR NTIRNFDVKS VKKEIWRGRR LKCSFCNKGG ATVGCDLWFC KKSYHYVCAK
KDQAILQVDG NHGTYKLFCP EHSPEQEEAT ESADDPSMKK KRGKNKRLSS GPPAQPKTMK
CSNAKRHMTE EPHGHTDAAV KSPFLKKCQE AGLLTELFEH ILENMDSVHG RLVDETASES
DYEGIETLLF DCGLFKDTLR KFQEVIKSKA CEWEERQRQM KQQLEALADL QQSLCSFQEN
GDLDCSSSTS GSLLPPEDHQ VRSQESPEVQ AGSGDSL
