PHF14_MOUSE
ID PHF14_MOUSE Reviewed; 881 AA.
AC Q9D4H9; Q810Z6; Q8C284; Q8CGF8; Q9D1Q8;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=PHD finger protein 14;
GN Name=Phf14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=FVB/N;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 513-881.
RC STRAIN=129S6/SvEvTac;
RA Brathwaite M.E., Waeltz P., Qian Y., Dudekula D., Schlessinger D.,
RA Nagaraja R.;
RT "Genomic sequence analysis in the mouse T-complex region.";
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-280 AND SER-283, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-280 AND SER-283, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-280; SER-283; SER-774 AND
RP SER-775, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9D4H9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D4H9-2; Sequence=VSP_010349;
CC Name=3;
CC IsoId=Q9D4H9-3; Sequence=VSP_010348;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB22644.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK003209; BAB22644.1; ALT_INIT; mRNA.
DR EMBL; AK016517; BAB30282.1; -; mRNA.
DR EMBL; AK089073; BAC40735.1; -; mRNA.
DR EMBL; BC040236; AAH40236.1; -; mRNA.
DR EMBL; AY162410; AAO17166.1; -; Genomic_DNA.
DR CCDS; CCDS39428.1; -. [Q9D4H9-1]
DR CCDS; CCDS51720.1; -. [Q9D4H9-2]
DR RefSeq; NP_001161854.1; NM_001168382.1. [Q9D4H9-2]
DR RefSeq; NP_083680.2; NM_029404.3.
DR AlphaFoldDB; Q9D4H9; -.
DR SMR; Q9D4H9; -.
DR BioGRID; 217694; 8.
DR STRING; 10090.ENSMUSP00000111172; -.
DR iPTMnet; Q9D4H9; -.
DR PhosphoSitePlus; Q9D4H9; -.
DR EPD; Q9D4H9; -.
DR jPOST; Q9D4H9; -.
DR MaxQB; Q9D4H9; -.
DR PaxDb; Q9D4H9; -.
DR PeptideAtlas; Q9D4H9; -.
DR PRIDE; Q9D4H9; -.
DR ProteomicsDB; 288192; -. [Q9D4H9-1]
DR ProteomicsDB; 288193; -. [Q9D4H9-2]
DR ProteomicsDB; 288194; -. [Q9D4H9-3]
DR Antibodypedia; 629; 89 antibodies from 24 providers.
DR DNASU; 75725; -.
DR Ensembl; ENSMUST00000090632; ENSMUSP00000088126; ENSMUSG00000029629. [Q9D4H9-3]
DR Ensembl; ENSMUST00000115511; ENSMUSP00000111173; ENSMUSG00000029629. [Q9D4H9-2]
DR GeneID; 75725; -.
DR KEGG; mmu:75725; -.
DR UCSC; uc009ayf.1; mouse. [Q9D4H9-1]
DR UCSC; uc009ayg.2; mouse. [Q9D4H9-2]
DR CTD; 9678; -.
DR MGI; MGI:1923539; Phf14.
DR VEuPathDB; HostDB:ENSMUSG00000029629; -.
DR eggNOG; KOG0957; Eukaryota.
DR GeneTree; ENSGT00940000156923; -.
DR HOGENOM; CLU_006506_0_0_1; -.
DR InParanoid; Q9D4H9; -.
DR OMA; LVMCDEC; -.
DR OrthoDB; 566217at2759; -.
DR PhylomeDB; Q9D4H9; -.
DR BioGRID-ORCS; 75725; 5 hits in 62 CRISPR screens.
DR ChiTaRS; Phf14; mouse.
DR PRO; PR:Q9D4H9; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9D4H9; protein.
DR Bgee; ENSMUSG00000029629; Expressed in manus and 252 other tissues.
DR ExpressionAtlas; Q9D4H9; baseline and differential.
DR Genevisible; Q9D4H9; MM.
DR GO; GO:0070776; C:MOZ/MORF histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048286; P:lung alveolus development; IMP:MGI.
DR GO; GO:0010463; P:mesenchymal cell proliferation; IMP:MGI.
DR GO; GO:0060916; P:mesenchymal cell proliferation involved in lung development; IMP:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:MGI.
DR GO; GO:0072201; P:negative regulation of mesenchymal cell proliferation; IMP:MGI.
DR GO; GO:2000791; P:negative regulation of mesenchymal cell proliferation involved in lung development; IMP:MGI.
DR GO; GO:2000584; P:negative regulation of platelet-derived growth factor receptor-alpha signaling pathway; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00628; PHD; 2.
DR SMART; SM00249; PHD; 3.
DR SUPFAM; SSF57903; SSF57903; 2.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 2.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Phosphoprotein; Reference proteome;
KW Repeat; Zinc; Zinc-finger.
FT CHAIN 1..881
FT /note="PHD finger protein 14"
FT /id="PRO_0000059307"
FT ZN_FING 312..373
FT /note="PHD-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT ZN_FING 375..408
FT /note="C2HC pre-PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT ZN_FING 432..492
FT /note="PHD-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT ZN_FING 718..772
FT /note="PHD-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT REGION 22..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..249
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..865
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 26
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94880"
FT MOD_RES 29
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94880"
FT MOD_RES 84
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94880"
FT MOD_RES 189
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94880"
FT MOD_RES 199
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:O94880"
FT MOD_RES 201
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94880"
FT MOD_RES 280
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:21183079"
FT MOD_RES 283
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:21183079"
FT MOD_RES 287
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94880"
FT MOD_RES 291
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94880"
FT MOD_RES 295
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94880"
FT MOD_RES 301
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94880"
FT MOD_RES 352
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94880"
FT MOD_RES 523
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94880"
FT MOD_RES 774
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 775
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 828
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94880"
FT VAR_SEQ 879..881
FT /note="NLT -> CDECRLCYHFGCLDPPLKKSPKQTGYGWICQECDSSSSKEDENEA
FT EKKNASQELSMEQKTPKK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010349"
FT VAR_SEQ 879..881
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_010348"
FT CONFLICT 133
FT /note="V -> I (in Ref. 2; AAH40236)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 881 AA; 99105 MW; 21E0EA172F96B20D CRC64;
MDRSSKRRQV KPLAASLLEA LDYDSSDDSD FKVGDASDSE GSGNGSEDPS KDSGEGSCSD
SEENILEEEL NEDIQVKEEQ LKNSTEEIMP SDKQLIKMEK KEEEENGERP RKKKEKEKEK
EKEREKDKEK ATVSDSAAAS AAGTTPATSP PAVTSPSVPT TTTTTTEEQV SEPKKWNLRR
NRPLLDFVSM EELNAMDDYD SEDDNDWRPT VVKRKGRSAS QKEGSDGDNE DDDDEGSGSE
EDENDEGNDE DHSSPASEAG GKKKRSKVLS RNSADDEELT NDSLTLSQSK SNEDSLILEK
SQNWSSQKMD HILICCVCLG DNSEDADEII QCDNCGITVH EGCYGVDGES DSIMSSASEN
STEPWFCDAC KCGVSPSCEL CPNQDGIFKE TDAGRWVHIV CALYVPGVAF GDIDKLRPVT
LTEMNYSKYG AKECSFCEDP RFARTGVCIS CDAGMCRAYF HVTCAQKEGL LSEAAAEEDI
ADPFFAYCKQ HADRLDRKWK RKNYLALQSY CKMSLQEREK QLSPEAQARI NARLQQYRAK
AELARSTRPQ AWVPREKLPR PLTSSASAIR KLMRKAELMG ISTDIFPVDN SDTSSSVDGR
RKHKQPALTA DFVNYYFERN MRMIQIQENM AEQKNIKDKL ENEQEKLHVE YNKLCESLEE
LQNLNGKLRS EGQGIWALLG RITGQKLNVP AILRAPKERK PSKKEGGTQK TSALPTVLYS
CGICKKNHDQ HLLLLCDTCK LHYHLGCLDP PLTRMPRKTK NSYWQCSECD QAGSSDMEAE
MAMETLPDGT KRSRRQIKEP VKFVPQDVPP EPKKIPIRNT RTRGRKRSFV PEEEKHEERV
PRERRQRQSV LQKKPKAEDL RTECSTCKGT GDNENLVRNL T
