位置:首页 > 蛋白库 > PHF1_ARATH
PHF1_ARATH
ID   PHF1_ARATH              Reviewed;         398 AA.
AC   Q8GYE0; Q9SUY6;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 2.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=SEC12-like protein 1;
DE   AltName: Full=Protein PHOSPHATE TRANSPORTER TRAFFIC FACILITATOR 1;
DE            Short=PHF-1;
GN   Name=PHF1; OrderedLocusNames=At3g52190; ORFNames=F4F15.300;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-398.
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA   Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA   Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND TISSUE SPECIFICITY.
RX   PubMed=16284308; DOI=10.1105/tpc.105.036640;
RA   Gonzalez E., Solano R., Rubio V., Leyva A., Paz-Ares J.;
RT   "PHOSPHATE TRANSPORTER TRAFFIC FACILITATOR1 is a plant-specific SEC12-
RT   related protein that enables the endoplasmic reticulum exit of a high-
RT   affinity phosphate transporter in Arabidopsis.";
RL   Plant Cell 17:3500-3512(2005).
RN   [5]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA   Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA   Giglione C.;
RT   "Comparative large-scale characterisation of plant vs. mammal proteins
RT   reveals similar and idiosyncratic N-alpha acetylation features.";
RL   Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
CC   -!- FUNCTION: Involved in Pi uptake by facilitating the trafficking of
CC       PHT1-1/PHT1;1 from the endoplasmic reticulum to the plasma membrane.
CC       {ECO:0000269|PubMed:16284308}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:16284308}; Single-pass membrane protein
CC       {ECO:0000269|PubMed:16284308}.
CC   -!- TISSUE SPECIFICITY: Ubiquitous with higher levels in flowers, roots and
CC       senescing leaves. {ECO:0000269|PubMed:16284308}.
CC   -!- INDUCTION: By Pi starvation. {ECO:0000269|PubMed:16284308}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC42349.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL049711; CAB41339.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE78911.1; -; Genomic_DNA.
DR   EMBL; AK117697; BAC42349.1; ALT_INIT; mRNA.
DR   PIR; T49098; T49098.
DR   RefSeq; NP_566961.1; NM_115079.4.
DR   AlphaFoldDB; Q8GYE0; -.
DR   SMR; Q8GYE0; -.
DR   BioGRID; 9702; 10.
DR   IntAct; Q8GYE0; 10.
DR   STRING; 3702.AT3G52190.1; -.
DR   iPTMnet; Q8GYE0; -.
DR   PaxDb; Q8GYE0; -.
DR   PRIDE; Q8GYE0; -.
DR   ProteomicsDB; 236728; -.
DR   EnsemblPlants; AT3G52190.1; AT3G52190.1; AT3G52190.
DR   GeneID; 824384; -.
DR   Gramene; AT3G52190.1; AT3G52190.1; AT3G52190.
DR   KEGG; ath:AT3G52190; -.
DR   Araport; AT3G52190; -.
DR   TAIR; locus:2083850; AT3G52190.
DR   eggNOG; KOG0771; Eukaryota.
DR   HOGENOM; CLU_058136_1_1_1; -.
DR   InParanoid; Q8GYE0; -.
DR   OMA; WNFPLGK; -.
DR   OrthoDB; 828247at2759; -.
DR   PhylomeDB; Q8GYE0; -.
DR   PRO; PR:Q8GYE0; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q8GYE0; baseline and differential.
DR   Genevisible; Q8GYE0; AT.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0016036; P:cellular response to phosphate starvation; IEP:TAIR.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IMP:TAIR.
DR   GO; GO:0006817; P:phosphate ion transport; IMP:TAIR.
DR   GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR   GO; GO:0003400; P:regulation of COPII vesicle coating; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR045260; Sec12-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR23284; PTHR23284; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Endoplasmic reticulum; Membrane; Protein transport;
KW   Reference proteome; Repeat; Signal-anchor; Transmembrane;
KW   Transmembrane helix; Transport; WD repeat.
FT   CHAIN           1..398
FT                   /note="SEC12-like protein 1"
FT                   /id="PRO_0000051123"
FT   TOPO_DOM        1..337
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        359..398
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REPEAT          71..110
FT                   /note="WD 1"
FT   REPEAT          120..159
FT                   /note="WD 2"
FT   REPEAT          162..201
FT                   /note="WD 3"
FT   REPEAT          252..291
FT                   /note="WD 4"
FT   REPEAT          296..334
FT                   /note="WD 5"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0007744|PubMed:22223895"
SQ   SEQUENCE   398 AA;  43767 MW;  687F04E70EA90728 CRC64;
     MEIEEASRES GHVVCGSWIR RPKKVNWVLI AKASKRRGSS VSSPALLNIF SFDPITASLS
     SSPLATHTLK DSDGDPVAVS VHPGGDYFVC STSKGGCKLF ELVGGATGIT ILAKELLPLQ
     NAGLQKCMAF SFDGSKLAVG GVDGCLRIME WPNLSVILDE PKAHKSIRDM DFSLDSEFLA
     TTSTDGSARI WKAEDGFPLS TLERSGDENI ELCRFSKDGT KPFLFCAAQR GDTPMVNVYD
     ISTWKKLGFK KLSRKTASTM AVSLDGKYIA LGGKDGDVSV AEVKTMEIYH YSKRLHLGQS
     IASLEFCPSE RVMLTTSSEW GEMVTKLTVP KEWKEWQIYA LLFCLFMASV IAAYVFFENS
     DSFWKLPMGK DQKRPKISLF GGSSSTPSED HSRWNLDL
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024