ID   PHF23_XENTR             Reviewed;         278 AA.
AC   Q5U5E5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=PHD finger protein 23A {ECO:0000305};
GN   Name=phf23 {ECO:0000305}; ORFNames=TEgg129n08.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of autophagy.
CC       {ECO:0000250|UniProtKB:Q9BUL5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BUL5}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9BUL5}.
CC   -!- DOMAIN: The PHD-type zinc-finger domain is required for negative
CC       regulation of autophagy. {ECO:0000250|UniProtKB:Q9BUL5}.
CC   -!- SIMILARITY: Belongs to the PHF23 family. {ECO:0000305}.
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DR   EMBL; CR942437; CAJ83696.1; -; mRNA.
DR   EMBL; BC084739; AAH84739.1; -; mRNA.
DR   RefSeq; NP_001011148.1; NM_001011148.1.
DR   AlphaFoldDB; Q5U5E5; -.
DR   SMR; Q5U5E5; -.
DR   DNASU; 496566; -.
DR   GeneID; 496566; -.
DR   KEGG; xtr:496566; -.
DR   CTD; 79142; -.
DR   Xenbase; XB-GENE-6455436; phf23.
DR   InParanoid; Q5U5E5; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:1902902; P:negative regulation of autophagosome assembly; ISS:GO_Central.
DR   GO; GO:1901097; P:negative regulation of autophagosome maturation; ISS:GO_Central.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; ISS:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   SMART; SM00249; PHD; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..278
FT                   /note="PHD finger protein 23A"
FT                   /id="PRO_0000302837"
FT   ZN_FING         216..264
FT                   /note="PHD-type"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          50..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..95
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..139
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..169
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   278 AA;  30183 MW;  6EB1687A7A93C011 CRC64;
     MLETTMGEAS PEDPPLNLKS LSQPPQKRSR TVEDFNRFCS FVLAYAGYIP TPAKEERAWT
     PPSSVSPHRT EESDGWDSPD PPQLPAPPEP PQPPATSDIS TIETFVMKAK SQGAGGGSSK
     MPGGQEDGAE EEEVQAKKGS RRKRRQRHRG GVRMSDTDTD EEEREERPAA PGSLPAPQLP
     PSAESSRDGG GSSSDADTQV MDEDIMVESG DDSWDLVTCY CEKPFAGRPM IECNVCCTWV
     HLSCAKIRKS NVPDVYYCQK CRAGRLPGAT TPKADSAP