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PHF24_HUMAN
ID   PHF24_HUMAN             Reviewed;         400 AA.
AC   Q9UPV7; B7Z253; Q58FE9; Q5T662;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 2.
DT   03-AUG-2022, entry version 152.
DE   RecName: Full=PHD finger protein 24 {ECO:0000312|HGNC:HGNC:29180};
GN   Name=PHF24 {ECO:0000312|HGNC:HGNC:29180};
GN   Synonyms=KIAA1045 {ECO:0000312|HGNC:HGNC:29180};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA   Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A.,
RA   Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XIV. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 6:197-205(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Amygdala;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-74.
RC   TISSUE=Brain;
RA   Liu D.X., Low J.S.W., Cui Y., Hsieh W.-S., Tao Q.;
RT   "Identification of candidate tumor suppressor genes in nasopharyngeal
RT   carcinoma using a combination of digital expression analysis, expression
RT   profiling and functional assay.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [7]
RP   MYRISTOYLATION AT GLY-2.
RX   PubMed=20213681; DOI=10.1002/pmic.200900783;
RA   Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E.,
RA   Tsunasawa S., Utsumi T.;
RT   "Strategy for comprehensive identification of human N-myristoylated
RT   proteins using an insect cell-free protein synthesis system.";
RL   Proteomics 10:1780-1793(2010).
RN   [8]
RP   STRUCTURE BY NMR OF 123-198 IN COMPLEX WITH ZINC.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structure of the RING finger domain of the human KIAA1045
RT   protein.";
RL   Submitted (NOV-2004) to the PDB data bank.
CC   -!- INTERACTION:
CC       Q9UPV7; P08754: GNAI3; NbExp=3; IntAct=EBI-17717171, EBI-357563;
CC       Q9UPV7; Q99471: PFDN5; NbExp=3; IntAct=EBI-17717171, EBI-357275;
CC       Q9UPV7; P07204: THBD; NbExp=3; IntAct=EBI-17717171, EBI-941422;
CC       Q9UPV7; Q9UPQ4-2: TRIM35; NbExp=3; IntAct=EBI-17717171, EBI-17716262;
CC       Q9UPV7; Q9H707: ZNF552; NbExp=3; IntAct=EBI-17717171, EBI-2555731;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA82997.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB028968; BAA82997.1; ALT_INIT; mRNA.
DR   EMBL; AK294342; BAH11739.1; -; mRNA.
DR   EMBL; AL355377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471071; EAW58408.1; -; Genomic_DNA.
DR   EMBL; AY956807; AAX51885.1; -; mRNA.
DR   EMBL; AY956808; AAX51886.1; -; mRNA.
DR   CCDS; CCDS43796.1; -.
DR   RefSeq; NP_001291262.1; NM_001304333.2.
DR   RefSeq; NP_056112.1; NM_015297.2.
DR   PDB; 1WIL; NMR; -; A=123-198.
DR   PDB; 5XHT; NMR; -; A=131-190.
DR   PDBsum; 1WIL; -.
DR   PDBsum; 5XHT; -.
DR   AlphaFoldDB; Q9UPV7; -.
DR   BMRB; Q9UPV7; -.
DR   SMR; Q9UPV7; -.
DR   BioGRID; 116931; 6.
DR   IntAct; Q9UPV7; 6.
DR   STRING; 9606.ENSP00000242315; -.
DR   iPTMnet; Q9UPV7; -.
DR   PhosphoSitePlus; Q9UPV7; -.
DR   BioMuta; PHF24; -.
DR   DMDM; 73621116; -.
DR   jPOST; Q9UPV7; -.
DR   MassIVE; Q9UPV7; -.
DR   PaxDb; Q9UPV7; -.
DR   PeptideAtlas; Q9UPV7; -.
DR   PRIDE; Q9UPV7; -.
DR   ProteomicsDB; 85455; -.
DR   Antibodypedia; 5591; 25 antibodies from 12 providers.
DR   DNASU; 23349; -.
DR   Ensembl; ENST00000242315.3; ENSP00000242315.3; ENSG00000122733.12.
DR   GeneID; 23349; -.
DR   KEGG; hsa:23349; -.
DR   MANE-Select; ENST00000242315.4; ENSP00000242315.3; NM_015297.3; NP_056112.1.
DR   UCSC; uc003zvr.4; human.
DR   CTD; 23349; -.
DR   DisGeNET; 23349; -.
DR   GeneCards; PHF24; -.
DR   HGNC; HGNC:29180; PHF24.
DR   HPA; ENSG00000122733; Group enriched (brain, testis).
DR   neXtProt; NX_Q9UPV7; -.
DR   OpenTargets; ENSG00000122733; -.
DR   PharmGKB; PA134993280; -.
DR   VEuPathDB; HostDB:ENSG00000122733; -.
DR   eggNOG; ENOG502QT6N; Eukaryota.
DR   GeneTree; ENSGT00390000002865; -.
DR   HOGENOM; CLU_057701_1_0_1; -.
DR   InParanoid; Q9UPV7; -.
DR   OMA; PQSCNVR; -.
DR   PhylomeDB; Q9UPV7; -.
DR   TreeFam; TF333336; -.
DR   PathwayCommons; Q9UPV7; -.
DR   SignaLink; Q9UPV7; -.
DR   BioGRID-ORCS; 23349; 7 hits in 1070 CRISPR screens.
DR   ChiTaRS; PHF24; human.
DR   EvolutionaryTrace; Q9UPV7; -.
DR   GenomeRNAi; 23349; -.
DR   Pharos; Q9UPV7; Tdark.
DR   PRO; PR:Q9UPV7; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q9UPV7; protein.
DR   Bgee; ENSG00000122733; Expressed in prefrontal cortex and 164 other tissues.
DR   Genevisible; Q9UPV7; HS.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR   GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:Ensembl.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; IEA:Ensembl.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR031946; KIAA1045_Zf_RING.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF16744; Zf_RING; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Lipoprotein; Metal-binding; Methylation; Myristate;
KW   Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..400
FT                   /note="PHD finger protein 24"
FT                   /id="PRO_0000059331"
FT   ZN_FING         129..190
FT                   /note="PHD-type"
FT   REGION          28..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..65
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..96
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         36
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q80TL4"
FT   MOD_RES         43
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:18669648"
FT   MOD_RES         47
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q80TL4"
FT   MOD_RES         51
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q80TL4"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000269|PubMed:20213681"
FT   TURN            134..136
FT                   /evidence="ECO:0007829|PDB:1WIL"
FT   STRAND          148..152
FT                   /evidence="ECO:0007829|PDB:1WIL"
FT   HELIX           156..162
FT                   /evidence="ECO:0007829|PDB:1WIL"
FT   STRAND          178..182
FT                   /evidence="ECO:0007829|PDB:1WIL"
FT   TURN            186..188
FT                   /evidence="ECO:0007829|PDB:1WIL"
FT   STRAND          193..195
FT                   /evidence="ECO:0007829|PDB:1WIL"
SQ   SEQUENCE   400 AA;  45192 MW;  96FE4C51C897888F CRC64;
     MGVLMSKRQT VEQVQKVSLA VSAFKDGLRD RPSIRRTGEL PGSRRGTVEG SVQEVQEEKE
     AEAGTSVVQE ESSAGRAAWE RLRDGRGVEP EEFDRTSRFT PPAFIRPTRK LDDDKPPEIC
     LEPREPVVND EMCDVCEVWT AESLFPCRVC TRVFHDGCLR RMGYIQGDSA AEVTEMAHTE
     TGWSCHYCDN INLLLTEEEM YSLTETFQRC KVIPDCSLTL EDFLRYRHQA AKRGDRDRAL
     SEEQEEQAAR QFAALDPEHR GHIEWPDFLS HESLLLLQQL RPQNSLLRLL TVKERERARA
     AFLARGSGST VSEAECRRAQ HSWFCKRFPE APSCSVSISH VGPIADSSPA SSSSKSQDKT
     LLPTEQESRF VDWPTFLQEN VLYILAARPN SAAIHLKPPG
 
 
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