PHF24_MOUSE
ID PHF24_MOUSE Reviewed; 400 AA.
AC Q80TL4; A2AG28; Q8BH08;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=PHD finger protein 24 {ECO:0000312|MGI:MGI:2140712};
GN Name=Phf24 {ECO:0000312|MGI:MGI:2140712};
GN Synonyms=Kiaa1045 {ECO:0000312|MGI:MGI:2140712},
GN N28178 {ECO:0000312|MGI:MGI:2140712};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-47 AND SER-51, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-36 AND ARG-307, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q80TL4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80TL4-2; Sequence=VSP_014952;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC65710.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK122428; BAC65710.1; ALT_INIT; mRNA.
DR EMBL; AK038528; BAC30029.1; -; mRNA.
DR EMBL; AK046283; BAC32670.1; -; mRNA.
DR EMBL; AL672276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057092; AAH57092.1; -; mRNA.
DR CCDS; CCDS18083.1; -. [Q80TL4-2]
DR CCDS; CCDS84719.1; -. [Q80TL4-1]
DR RefSeq; NP_001333455.1; NM_001346526.1. [Q80TL4-1]
DR RefSeq; NP_766278.1; NM_172690.2. [Q80TL4-2]
DR RefSeq; XP_006537878.1; XM_006537815.3. [Q80TL4-1]
DR RefSeq; XP_006537880.1; XM_006537817.2.
DR RefSeq; XP_006537882.1; XM_006537819.3. [Q80TL4-2]
DR RefSeq; XP_006537884.1; XM_006537821.1.
DR RefSeq; XP_011248294.1; XM_011249992.2.
DR RefSeq; XP_017175610.1; XM_017320121.1.
DR RefSeq; XP_017175611.1; XM_017320122.1.
DR RefSeq; XP_017175613.1; XM_017320124.1. [Q80TL4-2]
DR AlphaFoldDB; Q80TL4; -.
DR STRING; 10090.ENSMUSP00000103610; -.
DR iPTMnet; Q80TL4; -.
DR PhosphoSitePlus; Q80TL4; -.
DR SwissPalm; Q80TL4; -.
DR MaxQB; Q80TL4; -.
DR PaxDb; Q80TL4; -.
DR PeptideAtlas; Q80TL4; -.
DR PRIDE; Q80TL4; -.
DR ProteomicsDB; 301811; -. [Q80TL4-1]
DR ProteomicsDB; 301812; -. [Q80TL4-2]
DR Antibodypedia; 5591; 25 antibodies from 12 providers.
DR Ensembl; ENSMUST00000069184; ENSMUSP00000071011; ENSMUSG00000036062. [Q80TL4-2]
DR Ensembl; ENSMUST00000107975; ENSMUSP00000103609; ENSMUSG00000036062. [Q80TL4-1]
DR Ensembl; ENSMUST00000107976; ENSMUSP00000103610; ENSMUSG00000036062. [Q80TL4-2]
DR GeneID; 230085; -.
DR KEGG; mmu:230085; -.
DR UCSC; uc008soi.1; mouse. [Q80TL4-1]
DR UCSC; uc008soj.1; mouse. [Q80TL4-2]
DR CTD; 23349; -.
DR MGI; MGI:2140712; Phf24.
DR VEuPathDB; HostDB:ENSMUSG00000036062; -.
DR eggNOG; ENOG502QT6N; Eukaryota.
DR GeneTree; ENSGT00390000002865; -.
DR HOGENOM; CLU_057701_1_0_1; -.
DR InParanoid; Q80TL4; -.
DR OMA; PQSCNVR; -.
DR OrthoDB; 1485238at2759; -.
DR PhylomeDB; Q80TL4; -.
DR TreeFam; TF333336; -.
DR BioGRID-ORCS; 230085; 1 hit in 23 CRISPR screens.
DR ChiTaRS; Phf24; mouse.
DR PRO; PR:Q80TL4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80TL4; protein.
DR Bgee; ENSMUSG00000036062; Expressed in lumbar dorsal root ganglion and 130 other tissues.
DR ExpressionAtlas; Q80TL4; baseline and differential.
DR Genevisible; Q80TL4; MM.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IMP:MGI.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IMP:MGI.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IMP:MGI.
DR GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; IMP:MGI.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR031946; KIAA1045_Zf_RING.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF16744; Zf_RING; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Lipoprotein; Metal-binding; Methylation; Myristate;
KW Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9UPV7"
FT CHAIN 2..400
FT /note="PHD finger protein 24"
FT /id="PRO_0000059332"
FT ZN_FING 129..190
FT /note="PHD-type"
FT REGION 29..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 36
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 43
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UPV7"
FT MOD_RES 47
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 51
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 307
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 17..53
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_014952"
SQ SEQUENCE 400 AA; 45223 MW; 77B618690C0E4661 CRC64;
MGVLMSKRQT VEQVQKVSLA VSAFKDGLRD RPSIRRGGEL PGSRRGTVEG SVQEVQEEKE
AEASAPVVQE ESSINRAAWE RLRDGRGVEP EEFDRTSRFT PPAFIRPTRK LDDDKPPDIC
LEPREPVVND EMCDVCEVWT AESLFPCRVC TRVFHDGCLR RMGYLQGDSA VEVTEMAHTE
TGWSCYYCDN LNLLLTEEEM YSLTETFQRC KVIPDCSLTL EDFVRYRHQA AKRGESSRAL
TDEQEEQAAR QFAALDPEQR GHVEWSDFLS HESLLLLLQL RPQNSLLRLL TVKERERARA
TFLARGRGST ISEAECHHAR HSWFCKRLTE APSCSVSISH VGPIADSSPA ASSSKSQEKA
LLPTEQESRY VDWPTFLREN VIYILAARPN SGAIHLKPPG
