ID   PHF5A_DROME             Reviewed;         111 AA.
AC   Q9VMC8; B5RIJ7; Q8MQM8;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2003, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=PHD finger-like domain-containing protein 5A;
GN   Name=Phf5a {ECO:0000312|FlyBase:FBgn0031822};
GN   ORFNames=CG9548 {ECO:0000312|FlyBase:FBgn0031822};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Head;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley;
RA   Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.;
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the PHF5 family. {ECO:0000305}.
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DR   EMBL; AE014134; AAF52393.2; -; Genomic_DNA.
DR   EMBL; AY128489; AAM75082.1; -; mRNA.
DR   EMBL; BT044121; ACH92186.1; -; mRNA.
DR   RefSeq; NP_609038.1; NM_135194.3.
DR   AlphaFoldDB; Q9VMC8; -.
DR   SMR; Q9VMC8; -.
DR   BioGRID; 60066; 3.
DR   STRING; 7227.FBpp0078894; -.
DR   PaxDb; Q9VMC8; -.
DR   DNASU; 33909; -.
DR   EnsemblMetazoa; FBtr0079264; FBpp0078894; FBgn0031822.
DR   GeneID; 33909; -.
DR   KEGG; dme:Dmel_CG9548; -.
DR   UCSC; CG9548-RA; d. melanogaster.
DR   CTD; 84844; -.
DR   FlyBase; FBgn0031822; Phf5a.
DR   VEuPathDB; VectorBase:FBgn0031822; -.
DR   eggNOG; KOG1705; Eukaryota.
DR   GeneTree; ENSGT00390000018518; -.
DR   HOGENOM; CLU_110369_2_0_1; -.
DR   InParanoid; Q9VMC8; -.
DR   OMA; AYYCWEC; -.
DR   OrthoDB; 1477492at2759; -.
DR   PhylomeDB; Q9VMC8; -.
DR   Reactome; R-DME-72163; mRNA Splicing - Major Pathway.
DR   BioGRID-ORCS; 33909; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 33909; -.
DR   PRO; PR:Q9VMC8; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0031822; Expressed in egg cell and 25 other tissues.
DR   ExpressionAtlas; Q9VMC8; baseline and differential.
DR   Genevisible; Q9VMC8; DM.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; HDA:FlyBase.
DR   GO; GO:0071011; C:precatalytic spliceosome; HDA:FlyBase.
DR   GO; GO:0005689; C:U12-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; ISS:FlyBase.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:FlyBase.
DR   InterPro; IPR005345; PHF5.
DR   PANTHER; PTHR13120; PTHR13120; 1.
DR   Pfam; PF03660; PHF5; 1.
DR   PIRSF; PIRSF016468; PHF5; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..111
FT                   /note="PHD finger-like domain-containing protein 5A"
FT                   /id="PRO_0000218719"
FT   CONFLICT        108
FT                   /note="K -> R (in Ref. 3; AAM75082)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   111 AA;  12522 MW;  63D60ECB2C56663F CRC64;
     MAKHHPDLIF CRKQPGVAIG RLCEKDDGKC VICDSYVRPC TLVRICDECN YGSYQGRCVI
     CGGPGVSDAY YCKSCTIQEK DRDGCPKIVN LGSSKTDLFY ERKKYGFKQN Y