PHF7_MOUSE
ID PHF7_MOUSE Reviewed; 307 AA.
AC Q9DAG9; Q6PG81;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=PHD finger protein 7;
DE AltName: Full=Testis development protein NYD-SP6;
GN Name=Phf7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N-3; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=11829468; DOI=10.1006/bbrc.2002.6396;
RA Xiao J., Xu M., Li J., Chang Chan H., Lin M., Zhu H., Zhang W., Zhou Z.,
RA Zhao B., Sha J.H.;
RT "NYD-SP6, a novel gene potentially involved in regulating testicular
RT development/spermatogenesis.";
RL Biochem. Biophys. Res. Commun. 291:101-110(2002).
RN [4]
RP STRUCTURE BY NMR OF 232-304.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of PHD domain in PHD finger protein 7.";
RL Submitted (NOV-2004) to the PDB data bank.
CC -!- FUNCTION: May play a role in spermatogenesis.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9DAG9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DAG9-2; Sequence=VSP_013491;
CC -!- TISSUE SPECIFICITY: Highly expressed in Sertoli cells in testis.
CC {ECO:0000269|PubMed:11829468}.
CC -!- DEVELOPMENTAL STAGE: Expression levels increase during the first 4
CC weeks after birth and remain constant during the following 3 weeks.
CC {ECO:0000269|PubMed:11829468}.
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DR EMBL; AK005852; BAB24275.1; -; mRNA.
DR EMBL; BC057174; AAH57174.1; -; mRNA.
DR CCDS; CCDS26909.1; -. [Q9DAG9-1]
DR CCDS; CCDS88616.1; -. [Q9DAG9-2]
DR RefSeq; NP_082225.1; NM_027949.1. [Q9DAG9-1]
DR RefSeq; XP_006519646.1; XM_006519583.3.
DR PDB; 1WEQ; NMR; -; A=232-303.
DR PDBsum; 1WEQ; -.
DR AlphaFoldDB; Q9DAG9; -.
DR SMR; Q9DAG9; -.
DR IntAct; Q9DAG9; 1.
DR STRING; 10090.ENSMUSP00000022459; -.
DR PhosphoSitePlus; Q9DAG9; -.
DR PaxDb; Q9DAG9; -.
DR PRIDE; Q9DAG9; -.
DR ProteomicsDB; 287704; -. [Q9DAG9-1]
DR ProteomicsDB; 287705; -. [Q9DAG9-2]
DR Antibodypedia; 31216; 254 antibodies from 21 providers.
DR DNASU; 71838; -.
DR Ensembl; ENSMUST00000022459; ENSMUSP00000022459; ENSMUSG00000021902. [Q9DAG9-1]
DR Ensembl; ENSMUST00000226565; ENSMUSP00000154095; ENSMUSG00000021902. [Q9DAG9-2]
DR GeneID; 71838; -.
DR KEGG; mmu:71838; -.
DR UCSC; uc007sxf.1; mouse. [Q9DAG9-1]
DR UCSC; uc007sxg.1; mouse. [Q9DAG9-2]
DR CTD; 51533; -.
DR MGI; MGI:1919088; Phf7.
DR VEuPathDB; HostDB:ENSMUSG00000021902; -.
DR eggNOG; KOG1084; Eukaryota.
DR GeneTree; ENSGT00950000182865; -.
DR HOGENOM; CLU_055746_0_1_1; -.
DR InParanoid; Q9DAG9; -.
DR OMA; CSQTVYH; -.
DR PhylomeDB; Q9DAG9; -.
DR TreeFam; TF325426; -.
DR BioGRID-ORCS; 71838; 2 hits in 76 CRISPR screens.
DR ChiTaRS; Phf7; mouse.
DR EvolutionaryTrace; Q9DAG9; -.
DR PRO; PR:Q9DAG9; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q9DAG9; protein.
DR Bgee; ENSMUSG00000021902; Expressed in seminiferous tubule of testis and 250 other tissues.
DR ExpressionAtlas; Q9DAG9; baseline and differential.
DR Genevisible; Q9DAG9; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15669; ePHD_PHF7_G2E3_like; 1.
DR CDD; cd15496; PHD_PHF7_G2E3_like; 1.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR042013; PHF7/G2E3_ePHD.
DR InterPro; IPR042012; PHF7/G2E3_PHD.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS51805; EPHD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Metal-binding; Nucleus;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..307
FT /note="PHD finger protein 7"
FT /id="PRO_0000055997"
FT ZN_FING 30..68
FT /note="C2HC pre-PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT ZN_FING 96..145
FT /note="PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT ZN_FING 160..208
FT /note="RING-type; degenerate"
FT VAR_SEQ 228..266
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_013491"
FT STRAND 263..266
FT /evidence="ECO:0007829|PDB:1WEQ"
FT STRAND 274..276
FT /evidence="ECO:0007829|PDB:1WEQ"
FT HELIX 284..286
FT /evidence="ECO:0007829|PDB:1WEQ"
FT TURN 298..300
FT /evidence="ECO:0007829|PDB:1WEQ"
SQ SEQUENCE 307 AA; 35381 MW; B838B4CE2ED20BBA CRC64;
MKTLKEKNKH PRLRKTIRTK KVTQRKLSSS PVCLLCLQEP GDPEKLGEFL QKDNLCVHYF
CLILSSRLPQ KGQPNRGLHG FMPEDIKREA VRASKKICFV CKKKGAAIRC QNDQCVQNFH
LPCGQERGCL SQFFGEYKSY CRKHRPTQNI HQGSLGEESC VLCCENLSRT SVENIQSPCC
SQAIYHRKCI QKYAHTSAKH FFKCPQCNNR EEFPQEMLRM GIHIPDRDAA WELEPGAFSE
LYQRYRHCDA PICLYEQGRD SFEDEGRWRL ILCATCGSHG THRDCSSLRP NSKKWECNEC
LPASTTS
