PHG1B_DICDI
ID PHG1B_DICDI Reviewed; 587 AA.
AC Q54ZW0; Q54ZV9; Q6TU46; Q7YTA7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Putative phagocytic receptor 1b;
DE AltName: Full=SrfA-induced gene C protein;
DE Flags: Precursor;
GN Name=phg1b; Synonyms=sigC; ORFNames=DDB_G0277273;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RX PubMed=14665466; DOI=10.1128/ec.2.6.1327-1335.2003;
RA Escalante R., Moreno N., Sastre L.;
RT "Dictyostelium discoideum developmentally regulated genes whose expression
RT is dependent on MADS box transcription factor SrfA.";
RL Eukaryot. Cell 2:1327-1335(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ALTERNATIVE SPLICING, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=12857872; DOI=10.1091/mbc.e02-11-0724;
RA Benghezal M., Cornillon S., Gebbie L., Alibaud L., Bruckert F.,
RA Letourneur F., Cosson P.;
RT "Synergistic control of cellular adhesion by transmembrane 9 proteins.";
RL Mol. Biol. Cell 14:2890-2899(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [5]
RP DEVELOPMENTAL STAGE, AND INDUCTION BY SRFA.
RX PubMed=15075287; DOI=10.1128/ec.3.2.564-566.2004;
RA Escalante R., Iranfar N., Sastre L., Loomis W.F.;
RT "Identification of genes dependent on the MADS box transcription factor
RT SrfA in Dictyostelium discoideum development.";
RL Eukaryot. Cell 3:564-566(2004).
CC -!- FUNCTION: Involved in adhesion and phagocytosis of hydrophilic
CC particles. {ECO:0000269|PubMed:12857872}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=Q54ZW0-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=Q54ZW0-2; Sequence=VSP_032740;
CC -!- DEVELOPMENTAL STAGE: Expressed late in development. Isoform Long is
CC expressed in vegetative cells and at all stages of development. Isoform
CC Short is just observed in WT cells, at late developmental stages.
CC {ECO:0000269|PubMed:12857872, ECO:0000269|PubMed:15075287}.
CC -!- INDUCTION: Isoform Short is induced by SrfA.
CC {ECO:0000269|PubMed:14665466, ECO:0000269|PubMed:15075287}.
CC -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL68823.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY387646; AAQ95660.1; -; Genomic_DNA.
DR EMBL; AJ507828; CAD47840.1; -; mRNA.
DR EMBL; AAFI02000019; EAL68822.1; -; Genomic_DNA.
DR EMBL; AAFI02000019; EAL68823.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_642756.1; XM_637664.1.
DR RefSeq; XP_642757.1; XM_637665.1.
DR AlphaFoldDB; Q54ZW0; -.
DR STRING; 44689.DDB0185226; -.
DR PaxDb; Q54ZW0; -.
DR ABCD; Q54ZW0; 5 sequenced antibodies.
DR EnsemblProtists; EAL68822; EAL68822; DDB_G0277273.
DR EnsemblProtists; EAL68823; EAL68823; DDB_G0277273.
DR GeneID; 8620946; -.
DR KEGG; ddi:DDB_G0277273; -.
DR dictyBase; DDB_G0277273; phg1B.
DR eggNOG; KOG1277; Eukaryota.
DR InParanoid; Q54ZW0; -.
DR OMA; EWNGDRI; -.
DR PhylomeDB; Q54ZW0; -.
DR PRO; PR:Q54ZW0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:dictyBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:dictyBase.
DR GO; GO:0019954; P:asexual reproduction; IMP:dictyBase.
DR GO; GO:0031589; P:cell-substrate adhesion; IGI:dictyBase.
DR GO; GO:0006909; P:phagocytosis; IMP:dictyBase.
DR GO; GO:0072657; P:protein localization to membrane; IMP:dictyBase.
DR GO; GO:0033299; P:secretion of lysosomal enzymes; IMP:dictyBase.
DR GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR InterPro; IPR004240; EMP70.
DR PANTHER; PTHR10766; PTHR10766; 1.
DR Pfam; PF02990; EMP70; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..587
FT /note="Putative phagocytic receptor 1b"
FT /id="PRO_5000068833"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 448..468
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 556..576
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 93..265
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_032740"
FT CONFLICT 152
FT /note="N -> T (in Ref. 2; CAD47840)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 587 AA; 68547 MW; A18CD5FC2D78A87E CRC64;
MRLQILLIYL ICIIVSSIVL VESSNKHHFK ENDEVPFYVN NVGPYSNPTE TYEFYTLPFC
KPSSISYKKT KLGEILQGDS AVLSDYQFPF KSSFENKQLC EYTLKKEDIE KFKKAIGEYY
YAEMIYDDLP IFSFVGTVDD SDLTNIRYYL YNHIPFEFDY NGDQVIRVNI DTEHIKVIEL
SDQDEITLKL TYSAKWQPTE HEFSKRMDLY EEFFTKELEI HWLSVMNSFF LVVLLTAFLA
IMIMKILKND YSRYSKTDEE EDSDYQEDYG WKLVHGDVFR FPPYKNVFSA FYGIGWQFIS
IVCGILALSL FGMFYPNNGG NMYTAGIVLY ALTSGISGYQ SAKMYKNMGG NKWAWNIVLT
ATLFVAPLFI VVILSNTVAI TWHSTVALPI LTMIEVITIW LFVGFPLTVV GGIAGRRLSE
NFEAPCRTKN FPREVPPIQW YRRLPCQILI AGFLPFSAIY IELFYIFNSV WGHSTYTLYG
ILCLVFLILI NVTVCITVAL TYFQLSMEDH KWWWNSFING GSTVVFIYMY SIYYYYYISH
MYGLLQATFY FTYMLIVCFF FFILLGTVGF YSSLIFVKRI YRNLKSD
