PHG1C_DICDI
ID PHG1C_DICDI Reviewed; 655 AA.
AC Q7YTA6; Q54GG2;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Putative phagocytic receptor 1c;
DE Flags: Precursor;
GN Name=phg1c; ORFNames=DDB_G0290159;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12857872; DOI=10.1091/mbc.e02-11-0724;
RA Benghezal M., Cornillon S., Gebbie L., Alibaud L., Bruckert F.,
RA Letourneur F., Cosson P.;
RT "Synergistic control of cellular adhesion by transmembrane 9 proteins.";
RL Mol. Biol. Cell 14:2890-2899(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ507829; CAD47841.1; -; mRNA.
DR EMBL; AAFI02000158; EAL62351.1; -; Genomic_DNA.
DR RefSeq; XP_635866.1; XM_630774.1.
DR AlphaFoldDB; Q7YTA6; -.
DR STRING; 44689.DDB0191522; -.
DR PaxDb; Q7YTA6; -.
DR EnsemblProtists; EAL62351; EAL62351; DDB_G0290159.
DR GeneID; 8627522; -.
DR KEGG; ddi:DDB_G0290159; -.
DR dictyBase; DDB_G0290159; phg1c.
DR eggNOG; KOG1278; Eukaryota.
DR HOGENOM; CLU_010714_4_1_1; -.
DR InParanoid; Q7YTA6; -.
DR OMA; WKSIYAD; -.
DR PhylomeDB; Q7YTA6; -.
DR PRO; PR:Q7YTA6; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:dictyBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:dictyBase.
DR GO; GO:0006909; P:phagocytosis; TAS:dictyBase.
DR GO; GO:0072657; P:protein localization to membrane; IBA:GO_Central.
DR InterPro; IPR004240; EMP70.
DR PANTHER; PTHR10766; PTHR10766; 1.
DR Pfam; PF02990; EMP70; 1.
PE 2: Evidence at transcript level;
KW Membrane; Receptor; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..655
FT /note="Putative phagocytic receptor 1c"
FT /id="PRO_5000068834"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 518..538
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 550..570
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 587..607
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 619..639
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 146..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 655 AA; 74852 MW; 662CBDD5BD5E755F CRC64;
MLNIIVVLLL LFFSNNVIDS RYISYSKPNY YKTNDKIPVY MNNVRSGLSI FDYYKYPFPK
PSTIEYKQSF MSKLAGDLNS TSLYDEVSLH TSVDCIALGK PINYTLDDVN QLKYLIDKHF
RINFFIDDLP IGELFKNNRL VEYNNSNSKS SEITSPPSSP SSSSSSSSSP SSSIEEEDDD
DTENDHIYLG HPIGFKYNSK YYLYNHLIII INSTSTKSDK GFYTIKSVNV EPYSCVDCKI
DSGIGGVEIS PELFDDDKIK QLTIQYTYSI RNHETTTTNS GKSFQSWSIY YVNQFKLSNI
DIIMSFIIVL AVSACLAIIL LKIFRKTNSK TYTQLSPDDG GWKSIYADVF RSPNNFMTFS
IIIGFGVQIV ASLFILMVFS VAGLTSIATP GGMAIASILI FSFTGIFNGY SSMRTYIMLG
GTRKLYNSVI TTTLIPFTIL LLMFIGYFQV WSNKFTYGAS IGTVFFILAM WLLVCVPCSL
LSSYFVRTWP PAEYPVRINP IPRFIPTAKW YQNQYLHMIL GGIIPFVIIF TDLSFFLSSW
VLGEHYSYSL SFALTFILMI ISIVETNMII EYYQLSLENY NWWWRSLLGP MVTGLYTFIY
FIYFGITRIE TEGVGFYYFM FSLVFSILVS LFCSSIGFLG NLWFTKKIYS TLHFD
