ID   PHGR_EUBOX              Reviewed;          13 AA.
AC   P57793;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Phloroglucinol reductase;
DE            EC=1.3.1.57;
DE   Flags: Fragment;
OS   Eubacterium oxidoreducens.
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=1732;
RN   [1]
RP   PROTEIN SEQUENCE, AND CHARACTERIZATION.
RC   STRAIN=G-41;
RX   PubMed=2925649; DOI=10.1016/s0021-9258(18)83759-0;
RA   Haddock J.D., Ferry J.G.;
RT   "Purification and properties of phloroglucinol reductase from Eubacterium
RT   oxidoreducens G-41.";
RL   J. Biol. Chem. 264:4423-4427(1989).
CC   -!- FUNCTION: Functions in the pathway of anaerobic degradation of
CC       trihydroxybenzenes by catalyzing reduction of the aromatic nucleus
CC       prior to ring fission.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dihydrophloroglucinol + NADP(+) = 1,3,5-trihydroxybenzene +
CC         NADPH; Xref=Rhea:RHEA:10080, ChEBI:CHEBI:16204, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:77638; EC=1.3.1.57;
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Optimum pH is 7.8 for the forward reaction.;
CC       Temperature dependence:
CC         Optimum temperature is 40 degrees Celsius for the forward reaction.;
CC   -!- SUBUNIT: Homodimer.
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DR   PIR; A32453; A32453.
DR   BioCyc; MetaCyc:MON-4; -.
DR   BRENDA; 1.3.1.57; 2187.
DR   GO; GO:0018510; F:phloroglucinol reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Aromatic hydrocarbons catabolism; Direct protein sequencing; NADP;
KW   Oxidoreductase.
FT   CHAIN           1..>13
FT                   /note="Phloroglucinol reductase"
FT                   /id="PRO_0000058379"
FT   NON_TER         13
SQ   SEQUENCE   13 AA;  1530 MW;  427E2E0833F1CB13 CRC64;
     XVPCNKEFVX NXF