ID   PHIA_ASPFC              Reviewed;         185 AA.
AC   B0Y004;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Cell wall protein phiA {ECO:0000305};
DE   AltName: Full=Major allergen phiA;
DE   AltName: Full=Phialide development protein A {ECO:0000250|UniProtKB:Q5ATP7};
DE   AltName: Allergen=Asp f 34;
DE   Flags: Precursor;
GN   Name=phiA {ECO:0000250|UniProtKB:Q5ATP7};
GN   ORFNames=AFUB_045170 {ECO:0000312|EMBL:EDP53342.1};
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804 {ECO:0000312|Proteomes:UP000001699};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Cell wall protein involved in development of asexual
CC       structures such as phialide and conidium development, and thus required
CC       for spore formation (By similarity). Plays a role as a general stress
CC       protectant produced by the fungus in competition with antagonistic
CC       bacteria (By similarity). {ECO:0000250|UniProtKB:A2R2S8,
CC       ECO:0000250|UniProtKB:Q5ATP7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:D4AV66}.
CC       Secreted, cell wall {ECO:0000250|UniProtKB:Q5ATP7}.
CC   -!- ALLERGEN: May cause an allergic reaction in human. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the phiA family. {ECO:0000305}.
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DR   EMBL; DS499596; EDP53342.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0Y004; -.
DR   Allergome; 3672; Asp f 34.
DR   PRIDE; B0Y004; -.
DR   EnsemblFungi; EDP53342; EDP53342; AFUB_045170.
DR   VEuPathDB; FungiDB:AFUB_045170; -.
DR   HOGENOM; CLU_097238_0_0_1; -.
DR   PhylomeDB; B0Y004; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Allergen; Cell wall; Glycoprotein; Secreted; Signal; Sporulation.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..185
FT                   /note="Cell wall protein phiA"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000434418"
FT   CARBOHYD        60
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   185 AA;  19380 MW;  FC7B2F8BED541C8C CRC64;
     MQIKSFVLAA SAAATASAAA CQAPTNKYFG IVAIHSGSAV QYQPFSAAKS SIFAGLNSQN
     ASCDRPDEKS ATFYIQDGSL YLYAASATPQ EIFVDRSGMG QGKIGYTTGA QPAPRNSERQ
     GWAIDSQNHL QFQGKDLIAC PNSIDGAWSI WADAGVANPA GNTDCVGIAA RVEDVTNPNS
     CVYTQ