ID   PHIA_ASPFM              Reviewed;         185 AA.
AC   A4FSH5;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Cell wall protein phiA {ECO:0000305};
DE   AltName: Full=Major allergen phiA {ECO:0000305};
DE   AltName: Full=Phialide development protein A {ECO:0000250|UniProtKB:Q5ATP7};
DE   AltName: Allergen=Asp f 34 {ECO:0000303|PubMed:19416144};
DE   Flags: Precursor;
GN   Name=phiA {ECO:0000250|UniProtKB:Q5ATP7};
OS   Neosartorya fumigata (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=746128 {ECO:0000312|EMBL:CAM54066.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN, AND IGE-BINDING.
RC   STRAIN=ATCC 42202 / AF-102 / Ag 507;
RX   PubMed=19416144; DOI=10.1111/j.1398-9995.2009.02029.x;
RA   Glaser A.G., Kirsch A.I., Zeller S., Menz G., Rhyner C., Crameri R.;
RT   "Molecular and immunological characterization of Asp f 34, a novel major
RT   cell wall allergen of Aspergillus fumigatus.";
RL   Allergy 64:1144-1151(2009).
RN   [2]
RP   ALLERGEN, AND INDUCTION.
RC   STRAIN=ATCC 34506;
RX   PubMed=21724168; DOI=10.1016/j.funbio.2011.03.006;
RA   Low S.Y., Dannemiller K., Yao M., Yamamoto N., Peccia J.;
RT   "The allergenicity of Aspergillus fumigatus conidia is influenced by growth
RT   temperature.";
RL   Fungal Biol. 115:625-632(2011).
CC   -!- FUNCTION: Cell wall protein involved in development of asexual
CC       structures such as phialide and conidium development, and thus required
CC       for spore formation (By similarity). Plays a role as a general stress
CC       protectant produced by the fungus in competition with antagonistic
CC       bacteria (By similarity). {ECO:0000250|UniProtKB:A2R2S8,
CC       ECO:0000250|UniProtKB:Q5ATP7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:D4AV66}.
CC       Secreted, cell wall {ECO:0000250|UniProtKB:Q5ATP7}.
CC   -!- INDUCTION: Expression is higher at 32 degrees Celsius than at 17
CC       degrees Celsius. {ECO:0000269|PubMed:21724168}.
CC   -!- ALLERGEN: Major allergen that causes an allergic reaction in human.
CC       Binds to IgE. {ECO:0000269|PubMed:19416144,
CC       ECO:0000269|PubMed:21724168}.
CC   -!- SIMILARITY: Belongs to the phiA family. {ECO:0000305}.
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DR   EMBL; AM496018; CAM54066.1; -; mRNA.
DR   AlphaFoldDB; A4FSH5; -.
DR   Allergome; 3672; Asp f 34.
DR   Allergome; 3770; Asp f 34.0101.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Allergen; Cell wall; Glycoprotein; Secreted; Signal; Sporulation.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..185
FT                   /note="Cell wall protein phiA"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000434417"
FT   CARBOHYD        60
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   185 AA;  19380 MW;  FC7B2F8BED541C8C CRC64;
     MQIKSFVLAA SAAATASAAA CQAPTNKYFG IVAIHSGSAV QYQPFSAAKS SIFAGLNSQN
     ASCDRPDEKS ATFYIQDGSL YLYAASATPQ EIFVDRSGMG QGKIGYTTGA QPAPRNSERQ
     GWAIDSQNHL QFQGKDLIAC PNSIDGAWSI WADAGVANPA GNTDCVGIAA RVEDVTNPNS
     CVYTQ