ID   PHIA_ASPNC              Reviewed;         184 AA.
AC   A2R2S8;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Cell wall protein phiA {ECO:0000305};
DE   AltName: Full=Phialide development protein A {ECO:0000250|UniProtKB:Q5ATP7};
DE   Flags: Precursor;
GN   Name=phiA {ECO:0000250|UniProtKB:Q5ATP7}; ORFNames=An14g01820;
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA   Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA   Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA   Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA   Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA   Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA   Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
RN   [2]
RP   INDUCTION.
RX   PubMed=22222772; DOI=10.1016/j.fgb.2011.12.008;
RA   Schachtschabel D., Arentshorst M., Lagendijk E.L., Ram A.F.;
RT   "Vacuolar H(+)-ATPase plays a key role in cell wall biosynthesis of
RT   Aspergillus niger.";
RL   Fungal Genet. Biol. 49:284-293(2012).
RN   [3]
RP   INDUCTION, AND FUNCTION.
RX   PubMed=24229396; DOI=10.1186/1756-0500-6-464;
RA   Svanstroem A., Boveri S., Bostroem E., Melin P.;
RT   "The lactic acid bacteria metabolite phenyllactic acid inhibits both radial
RT   growth and sporulation of filamentous fungi.";
RL   BMC Res. Notes 6:464-464(2013).
CC   -!- FUNCTION: Cell wall protein involved in development of asexual
CC       structures such as phialide and conidium development, and thus required
CC       for spore formation (By similarity). Plays a role as a general stress
CC       protectant produced by the fungus in competition with antagonistic
CC       bacteria (PubMed:24229396). {ECO:0000250|UniProtKB:Q5ATP7,
CC       ECO:0000269|PubMed:24229396}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:D4AV66}.
CC       Secreted, cell wall {ECO:0000250|UniProtKB:Q5ATP7}.
CC   -!- INDUCTION: Expression is highly induced by the V-ATPase inhibitor
CC       bafilomycin B1 (PubMed:22222772). Expression is also increased by the
CC       anti-fungal factor phenyllactic acid (PLA) (PubMed:24229396).
CC       {ECO:0000269|PubMed:22222772, ECO:0000269|PubMed:24229396}.
CC   -!- SIMILARITY: Belongs to the phiA family. {ECO:0000305}.
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DR   EMBL; AM270315; CAK46494.1; -; Genomic_DNA.
DR   RefSeq; XP_001400808.1; XM_001400771.2.
DR   AlphaFoldDB; A2R2S8; -.
DR   PaxDb; A2R2S8; -.
DR   PRIDE; A2R2S8; -.
DR   EnsemblFungi; CAK46494; CAK46494; An14g01820.
DR   GeneID; 4987038; -.
DR   KEGG; ang:ANI_1_280124; -.
DR   VEuPathDB; FungiDB:An14g01820; -.
DR   HOGENOM; CLU_097238_0_0_1; -.
DR   Proteomes; UP000006706; Chromosome 1R.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cell wall; Glycoprotein; Reference proteome; Secreted; Signal; Sporulation.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..184
FT                   /note="Cell wall protein phiA"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000434420"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   184 AA;  19180 MW;  4490FB21AEBDD3CB CRC64;
     MQLKNLIFAA ATAAALPATD AATNEPFGVI SIHSGSGVQY APINAALGSI FAGLKSQNAS
     CSNPQDQTAT FFLDDGALYL YDQSATPQEL YVDRSGMGQG KIGYTTGAQP APKNGERKGW
     SIDANNHLQF GGKDLIACPN SIEGAWSIWA DAGVAKPGYN EGCEGIAARV EVSKNPNVCS
     YTSN