ID   ASTA_PACLE              Reviewed;         104 AA.
AC   Q56R11;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Astakine;
DE   AltName: Full=Prokineticin-like cytokine;
DE   Flags: Precursor;
OS   Pacifastacus leniusculus (Signal crayfish).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea;
OC   Astacoidea; Astacidae; Pacifastacus.
OX   NCBI_TaxID=6720;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-69; 72-79 AND 92-104,
RP   AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=15879111; DOI=10.4049/jimmunol.174.10.6153;
RA   Soderhall I., Kim Y.-A., Jiravanichpaisal P., Lee S.-Y., Soderhall K.;
RT   "An ancient role for a prokineticin domain in invertebrate hematopoiesis.";
RL   J. Immunol. 174:6153-6160(2005).
CC   -!- FUNCTION: Cytokine directly involved in hematopoiesis.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the AVIT (prokineticin) family. {ECO:0000305}.
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DR   EMBL; AY787656; AAX14635.1; -; mRNA.
DR   AlphaFoldDB; Q56R11; -.
DR   SMR; Q56R11; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR023569; Prokineticin_domain.
DR   Pfam; PF06607; Prokineticin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..104
FT                   /note="Astakine"
FT                   /id="PRO_0000267484"
FT   DISULFID        25..38
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..50
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..76
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..84
FT                   /evidence="ECO:0000250"
FT   DISULFID        78..91
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   104 AA;  10949 MW;  9BDC3995F5F6C68A CRC64;
     MKMRGVSVGV LVVAMMSGLA MAGSCNSQEP DCGPSECCLQ GWMRYSTRGC APLGEAGSSC
     NVFTQAPVKG FYIGMCPCRA GLVCTRPSAT CQLPSQDNTL DSYY