PHIPL_MOUSE
ID PHIPL_MOUSE Reviewed; 375 AA.
AC Q8BGT8; A4FVA0; Q8BZJ1; Q8C0X3; Q8CFU1; Q8R0C1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Phytanoyl-CoA hydroxylase-interacting protein-like;
GN Name=Phyhipl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RC TISSUE=Diencephalon, Olfactory bulb, Spinal cord, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 10-375 (ISOFORM 2).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; SER-12; SER-15 AND
RP SER-24, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in the development of the central system.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BGT8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BGT8-2; Sequence=VSP_034070;
CC -!- SIMILARITY: Belongs to the PHYHIP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI25000.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
CC Sequence=BAC28713.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK029522; BAC26493.1; -; mRNA.
DR EMBL; AK032166; BAC27735.1; -; mRNA.
DR EMBL; AK034448; BAC28713.1; ALT_FRAME; mRNA.
DR EMBL; AK083011; BAC38729.1; -; mRNA.
DR EMBL; BC027081; AAH27081.1; -; mRNA.
DR EMBL; BC037618; AAH37618.2; -; mRNA.
DR EMBL; BC124999; AAI25000.1; ALT_SEQ; mRNA.
DR CCDS; CCDS23914.1; -. [Q8BGT8-1]
DR RefSeq; NP_001156318.1; NM_001162846.1.
DR RefSeq; NP_848736.2; NM_178621.4. [Q8BGT8-1]
DR AlphaFoldDB; Q8BGT8; -.
DR SMR; Q8BGT8; -.
DR BioGRID; 214338; 1.
DR IntAct; Q8BGT8; 1.
DR MINT; Q8BGT8; -.
DR STRING; 10090.ENSMUSP00000045807; -.
DR GlyGen; Q8BGT8; 2 sites.
DR iPTMnet; Q8BGT8; -.
DR PhosphoSitePlus; Q8BGT8; -.
DR SwissPalm; Q8BGT8; -.
DR jPOST; Q8BGT8; -.
DR MaxQB; Q8BGT8; -.
DR PaxDb; Q8BGT8; -.
DR PeptideAtlas; Q8BGT8; -.
DR PRIDE; Q8BGT8; -.
DR ProteomicsDB; 288199; -. [Q8BGT8-1]
DR ProteomicsDB; 288200; -. [Q8BGT8-2]
DR Antibodypedia; 45121; 43 antibodies from 17 providers.
DR Ensembl; ENSMUST00000046513; ENSMUSP00000045807; ENSMUSG00000037747. [Q8BGT8-1]
DR GeneID; 70911; -.
DR KEGG; mmu:70911; -.
DR UCSC; uc007fnz.2; mouse. [Q8BGT8-1]
DR UCSC; uc007fob.2; mouse. [Q8BGT8-2]
DR CTD; 84457; -.
DR MGI; MGI:1918161; Phyhipl.
DR VEuPathDB; HostDB:ENSMUSG00000037747; -.
DR eggNOG; ENOG502QQIT; Eukaryota.
DR GeneTree; ENSGT00390000014563; -.
DR InParanoid; Q8BGT8; -.
DR OMA; QLMSMST; -.
DR OrthoDB; 659430at2759; -.
DR PhylomeDB; Q8BGT8; -.
DR TreeFam; TF314485; -.
DR BioGRID-ORCS; 70911; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Phyhipl; mouse.
DR PRO; PR:Q8BGT8; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8BGT8; protein.
DR Bgee; ENSMUSG00000037747; Expressed in spermatid and 196 other tissues.
DR ExpressionAtlas; Q8BGT8; baseline and differential.
DR Genevisible; Q8BGT8; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR042868; PHYHIP/PHYHIPL.
DR InterPro; IPR045545; PHYIP/PHIPL_C.
DR PANTHER; PTHR15698; PTHR15698; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF19281; PHYHIP_C; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Phosphoprotein; Reference proteome.
FT CHAIN 1..375
FT /note="Phytanoyl-CoA hydroxylase-interacting protein-like"
FT /id="PRO_0000338642"
FT DOMAIN 51..160
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT MOD_RES 11
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 15
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 199..375
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034070"
FT CONFLICT 15
FT /note="S -> I (in Ref. 1; BAC26493)"
FT /evidence="ECO:0000305"
FT CONFLICT 78
FT /note="R -> H (in Ref. 1; BAC28713)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 375 AA; 42341 MW; 7091CC98C802941A CRC64;
MEVPRLDHAL SSPSSPCEEI KNLSLEAIQL CDRDGNKSQD SGIAEMEELP VPHNIKINNI
TCDSFKISWD MDSKSKDRIT HYFIDLNKKE NKNSNKFKHK DVPTKLVAKA VPLPMTVRGH
WFLSPRTEYT VAVQTASKQV DGDYVVSEWS EIIEFCTADY SKVHLTQLLE KADVIAGRML
KFSVFYRNQH KEYFDYVREH YGNAMQPSIK DNSGSHGSPI SGKLEGIFFS CSTEFNTGKP
PQDSPYGRYR FEIAAEKLFN PNTNLYFGDF YCMYTAYHYV ILVIAPVGSP GDEFCKQRLP
QLNSKDNNFL TCTEEDGVLV YHHAQDVILE VIYTDPVALS LGTVAEITGH QLMSLSTANA
KKDPSCKTCN ISVGR
