ID   ASTA_PENMO              Reviewed;         124 AA.
AC   Q56R10;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Astakine;
DE   Flags: Precursor;
OS   Penaeus monodon (Giant tiger prawn).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Penaeus.
OX   NCBI_TaxID=6687;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15879111; DOI=10.4049/jimmunol.174.10.6153;
RA   Soderhall I., Kim Y.-A., Jiravanichpaisal P., Lee S.-Y., Soderhall K.;
RT   "An ancient role for a prokineticin domain in invertebrate hematopoiesis.";
RL   J. Immunol. 174:6153-6160(2005).
CC   -!- FUNCTION: Cytokine directly involved in hematopoiesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AVIT (prokineticin) family. {ECO:0000305}.
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DR   EMBL; AY787657; AAX14636.1; -; mRNA.
DR   AlphaFoldDB; Q56R10; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR023569; Prokineticin_domain.
DR   Pfam; PF06607; Prokineticin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..124
FT                   /note="Astakine"
FT                   /id="PRO_0000267485"
FT   DISULFID        28..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..52
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..91
FT                   /evidence="ECO:0000250"
FT   DISULFID        62..99
FT                   /evidence="ECO:0000250"
FT   DISULFID        93..106
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   124 AA;  13309 MW;  BC59226F71532C7E CRC64;
     MAVSSAVRML SVACLVVSAA GMRRLGDCSS SADCGPGACC TIGFNRYSIP QCTPLGDLGD
     WCRVMNPPRE LSLAYPNGLQ VLLTDSYHGM CPCRPELACS RATSTCQLPQ ESTQHQEDNS
     LYKD