ID   PHK_BRUME               Reviewed;         792 AA.
AC   Q8YBL8;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Probable phosphoketolase;
DE            EC=4.1.2.-;
GN   OrderedLocusNames=BMEII0881;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the XFP family. {ECO:0000305}.
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DR   EMBL; AE008918; AAL54123.1; -; Genomic_DNA.
DR   PIR; AH3619; AH3619.
DR   RefSeq; WP_002968355.1; NZ_GG703779.1.
DR   AlphaFoldDB; Q8YBL8; -.
DR   SMR; Q8YBL8; -.
DR   STRING; 224914.BMEII0881; -.
DR   EnsemblBacteria; AAL54123; AAL54123; BMEII0881.
DR   GeneID; 29595422; -.
DR   KEGG; bme:BMEII0881; -.
DR   PATRIC; fig|224914.52.peg.2480; -.
DR   eggNOG; COG3957; Bacteria.
DR   OMA; LSTMDHC; -.
DR   PhylomeDB; Q8YBL8; -.
DR   Proteomes; UP000000419; Chromosome II.
DR   GO; GO:0016832; F:aldehyde-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.920; -; 1.
DR   HAMAP; MF_01403; Phosphoketolase; 1.
DR   InterPro; IPR023962; Phosphoketolase.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005593; Xul5P/Fru6P_PKetolase.
DR   InterPro; IPR018969; Xul5P/Fru6P_PKetolase_C.
DR   InterPro; IPR019790; Xul5P/Fru6P_PKetolase_CS.
DR   InterPro; IPR018970; Xul5P/Fru6P_PKetolase_N.
DR   InterPro; IPR019789; Xul5P/Fru6P_PKetolase_ThDP_BS.
DR   PANTHER; PTHR31273; PTHR31273; 1.
DR   Pfam; PF03894; XFP; 1.
DR   Pfam; PF09363; XFP_C; 1.
DR   Pfam; PF09364; XFP_N; 1.
DR   PIRSF; PIRSF017245; Phosphoketolase; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS60002; PHOSPHOKETOLASE_1; 1.
DR   PROSITE; PS60003; PHOSPHOKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Lyase; Thiamine pyrophosphate.
FT   CHAIN           1..792
FT                   /note="Probable phosphoketolase"
FT                   /id="PRO_0000193872"
SQ   SEQUENCE   792 AA;  89527 MW;  EC097721DEEB711A CRC64;
     MSTVPAKGPL TPQQLSLINR YWRAANYLSV GQIYLMKNPL LREPLQPEHI KPRLLGHWGT
     TPGLNFIYAH LNRIIQQRNA NVIYICGPGH GGPGMVANTY LEGTYSEIYP AISEDEAGME
     RLFRQFSFPG GIPSHAAPET PGSIHEGGEL GYALVHAYGA AFDNPDLVVA CVVGDGEAET
     GALATSWHSN KFLNPARDGA VLPILHLNGY KIANPTVLAR LSDDDLDNLF RGYGYEPFFV
     EGSEPADMHQ KMAATLDTIF QRIQDIKKNA DVHSPERPRW PMIILRSPKG WTGPKTVDGL
     VVENYWRAHQ VPVANCREND AHRKILEDWM KSYDPSDLFD EKGALKPELR ALAPKGEARI
     GANPHANGGL LRKELHMPDF RQYAVNVTEP GAIEAQSTKI LGDFLRDVMK LNETEKNFRI
     FGPDETASNR LGSVLEATNR VWMAETLDMD DHLAADGRVM EVLSEHLCQG WLEGYLLSGR
     HGFFSCYEAF IHIIDSMFNQ HAKWLQVARE LEWRKPISSL NYLLTSHVWR QDHNGFSHQD
     PGFVDLVANK SADIARVYFP PDANTLLWVG DHCLKTWNRV NVIVAGKQPE PQWLTMAEAE
     KHCEAGLGIW EWAGTEDGLE PDIVMACAGD VPTMETLAAV DLLRQSLPHL RIRVVNVVDL
     MVLQSPHQHP HGISDEEFDR MFTTNRPVIF AYHGYPYLIH RLVYKRTNHS NFHVRGFIEQ
     GTTTTPFDMT VLNELDRFHL AMEAVERLPL GESVAKPLID NFTEKLALHK DYIRQHGEDM
     PEIRDWKWTW PR