ID   PHK_CLOAB               Reviewed;         796 AA.
AC   Q97JE3;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Probable phosphoketolase;
DE            EC=4.1.2.-;
GN   OrderedLocusNames=CA_C1343;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the XFP family. {ECO:0000305}.
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DR   EMBL; AE001437; AAK79311.1; -; Genomic_DNA.
DR   PIR; D97065; D97065.
DR   RefSeq; NP_347971.1; NC_003030.1.
DR   RefSeq; WP_010964652.1; NC_003030.1.
DR   AlphaFoldDB; Q97JE3; -.
DR   SMR; Q97JE3; -.
DR   STRING; 272562.CA_C1343; -.
DR   EnsemblBacteria; AAK79311; AAK79311; CA_C1343.
DR   GeneID; 44997848; -.
DR   KEGG; cac:CA_C1343; -.
DR   PATRIC; fig|272562.8.peg.1548; -.
DR   eggNOG; COG3957; Bacteria.
DR   HOGENOM; CLU_013954_2_0_9; -.
DR   OMA; EHMCQGF; -.
DR   OrthoDB; 45239at2; -.
DR   BRENDA; 4.1.2.9; 1452.
DR   Proteomes; UP000000814; Chromosome.
DR   GO; GO:0016832; F:aldehyde-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.920; -; 1.
DR   HAMAP; MF_01403; Phosphoketolase; 1.
DR   InterPro; IPR023962; Phosphoketolase.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005593; Xul5P/Fru6P_PKetolase.
DR   InterPro; IPR018969; Xul5P/Fru6P_PKetolase_C.
DR   InterPro; IPR019790; Xul5P/Fru6P_PKetolase_CS.
DR   InterPro; IPR018970; Xul5P/Fru6P_PKetolase_N.
DR   InterPro; IPR019789; Xul5P/Fru6P_PKetolase_ThDP_BS.
DR   PANTHER; PTHR31273; PTHR31273; 1.
DR   Pfam; PF03894; XFP; 1.
DR   Pfam; PF09363; XFP_C; 1.
DR   Pfam; PF09364; XFP_N; 1.
DR   PIRSF; PIRSF017245; Phosphoketolase; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS60002; PHOSPHOKETOLASE_1; 1.
DR   PROSITE; PS60003; PHOSPHOKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome; Thiamine pyrophosphate.
FT   CHAIN           1..796
FT                   /note="Probable phosphoketolase"
FT                   /id="PRO_0000193875"
SQ   SEQUENCE   796 AA;  90640 MW;  4B8219DC9778FAEF CRC64;
     MQSIIGKHKD EGKITPEYLK KIDAYWRAAN FISVGQLYLL DNPLLREPLK PEHLKRKVVG
     HWGTIPGQNF IYAHLNRVIK KYDLDMIYVS GPGHGGQVMV SNSYLDGTYS EVYPNVSRDL
     NGLKKLCKQF SFPGGISSHM APETPGSINE GGELGYSLAH SFGAVFDNPD LITACVVGDG
     EAETGPLATS WQANKFLNPV TDGAVLPILH LNGYKISNPT VLSRIPKDEL EKFFEGNGWK
     PYFVEGEDPE TMHKLMAETL DIVTEEILNI QKNARENNDC SRPKWPMIVL RTPKGWTGPK
     FVDGVPNEGS FRAHQVPLAV DRYHTENLDQ LEEWLKSYKP EELFDENYRL IPELEELTPK
     GNKRMAANLH ANGGLLLREL RTPDFRDYAV DVPTPGSTVK QDMIELGKYV RDVVKLNEDT
     RNFRIFGPDE TMSNRLWAVF EGTKRQWLSE IKEPNDEFLS NDGRIVDSML SEHLCEGWLE
     GYLLTGRHGF FASYEAFLRI VDSMITQHGK WLKVTSQLPW RKDIASLNLI ATSNVWQQDH
     NGYTHQDPGL LGHIVDKKPE IVRAYLPADA NTLLAVFDKC LHTKHKINLL VTSKHPRQQW
     LTMDQAVKHV EQGISIWDWA SNDKGQEPDV VIASCGDTPT LEALAAVTIL HEHLPELKVR
     FVNVVDMMKL LPENEHPHGL SDKDYNALFT TDKPVIFAFH GFAHLINQLT YHRENRNLHV
     HGYMEEGTIT TPFDMRVQNK LDRFNLVKDV VENLPQLGNR GAHLVQLMND KLVEHNQYIR
     EVGEDLPEIT NWQWHV