ID   PHK_LACLA               Reviewed;         822 AA.
AC   Q9CFH4;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Probable phosphoketolase;
DE            EC=4.1.2.-;
GN   OrderedLocusNames=LL1502; ORFNames=L138230;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the XFP family. {ECO:0000305}.
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DR   EMBL; AE005176; AAK05600.1; -; Genomic_DNA.
DR   PIR; F86812; F86812.
DR   RefSeq; NP_267658.1; NC_002662.1.
DR   RefSeq; WP_010906007.1; NC_002662.1.
DR   PDB; 6GUA; Other; 1.95 A; A/B/C/D/E/F/G/H=1-822.
DR   PDBsum; 6GUA; -.
DR   AlphaFoldDB; Q9CFH4; -.
DR   SASBDB; Q9CFH4; -.
DR   SMR; Q9CFH4; -.
DR   STRING; 272623.L138230; -.
DR   PaxDb; Q9CFH4; -.
DR   PRIDE; Q9CFH4; -.
DR   EnsemblBacteria; AAK05600; AAK05600; L138230.
DR   KEGG; lla:L138230; -.
DR   PATRIC; fig|272623.7.peg.1612; -.
DR   eggNOG; COG3957; Bacteria.
DR   HOGENOM; CLU_013954_2_0_9; -.
DR   OMA; KQPRQQW; -.
DR   BRENDA; 4.1.2.22; 2864.
DR   BRENDA; 4.1.2.9; 2864.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0016832; F:aldehyde-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.920; -; 1.
DR   HAMAP; MF_01403; Phosphoketolase; 1.
DR   InterPro; IPR023962; Phosphoketolase.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005593; Xul5P/Fru6P_PKetolase.
DR   InterPro; IPR018969; Xul5P/Fru6P_PKetolase_C.
DR   InterPro; IPR019790; Xul5P/Fru6P_PKetolase_CS.
DR   InterPro; IPR018970; Xul5P/Fru6P_PKetolase_N.
DR   InterPro; IPR019789; Xul5P/Fru6P_PKetolase_ThDP_BS.
DR   PANTHER; PTHR31273; PTHR31273; 1.
DR   Pfam; PF03894; XFP; 1.
DR   Pfam; PF09363; XFP_C; 1.
DR   Pfam; PF09364; XFP_N; 1.
DR   PIRSF; PIRSF017245; Phosphoketolase; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS60002; PHOSPHOKETOLASE_1; 1.
DR   PROSITE; PS60003; PHOSPHOKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   3D-structure; Lyase; Reference proteome; Thiamine pyrophosphate.
FT   CHAIN           1..822
FT                   /note="Probable phosphoketolase"
FT                   /id="PRO_0000193877"
SQ   SEQUENCE   822 AA;  93363 MW;  C686D569D3E8E22F CRC64;
     MTEYNSEAYL KKLDKWWRAA TYLGAGMIFL KENPLFSVTG TPIKAENLKA NPIGHWGTVS
     GQTFLYAHAN RLINKYDQKM FYMGGPGHGG QAMVVPSYLD GSYTEAYPEI TQDLEGMSRL
     FKRFSFPGGI GSHMTAQTPG SLHEGGELGY VLSHATGAIL DQPEQIAFAV VGDGEAETGP
     LMTSWHSIKF INPKNDGAIL PILDLNGFKI SNPTLFARTS DVDIRKFFEG LGYSPRYIEN
     DDIHDYMAYH KLAAEVFDKA IEDIHQIQKD AREDNRYQNG EIPAWPIVIA RLPKGWGGPR
     YNDWSGPKFD GKGMPIEHSF RAHQVPLPLS SKNMGTLPEF VKWMTSYQPE TLFNADGSLK
     EELRDFAPKG EMRMASNPVT NGGVDSSNLV LPDWQEFANP ISENNRGKLL PDTNDNMDMN
     VLSKYFAEIV KLNPTRFRLF GPDETMSNRF WEMFKVTNRQ WMQVIKNPND EFISPEGRII
     DSQLSEHQAE GWLEGYTLTG RTGAFASYES FLRVVDSMLT QHFKWIRQAA DQKWRHDYPS
     LNVISTSTVF QQDHNGYTHQ DPGMLTHLAE KKSDFIRQYL PADGNTLLAV FDRAFQDRSK
     INHIVASKQP RQQWFTKEEA EKLATDGIAT IDWASTAKDG EAVDLVFASA GAEPTIETLA
     ALHLVNEVFP QAKFRYVNVV ELGRLQKKKG ALNQERELSD EEFEKYFGPS GTPVIFGFHG
     YEDLIESIFY QRGHDGLIVH GYREDGDITT TYDMRVYSEL DRFHQAIDAM QVLYVNRKVN
     QGLAKAFIDR MKRTLVKHFE VTRNEGVDIP DFTEWVWSDL KK