ID   PHK_MYCPA               Reviewed;         804 AA.
AC   Q73ZM8;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Probable phosphoketolase {ECO:0000255|HAMAP-Rule:MF_01403};
DE            EC=4.1.2.- {ECO:0000255|HAMAP-Rule:MF_01403};
GN   OrderedLocusNames=MAP_1573c;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01403};
CC   -!- SIMILARITY: Belongs to the XFP family. {ECO:0000255|HAMAP-
CC       Rule:MF_01403}.
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DR   EMBL; AE016958; AAS03890.1; -; Genomic_DNA.
DR   RefSeq; WP_003876539.1; NC_002944.2.
DR   AlphaFoldDB; Q73ZM8; -.
DR   SMR; Q73ZM8; -.
DR   STRING; 262316.MAP_1573c; -.
DR   EnsemblBacteria; AAS03890; AAS03890; MAP_1573c.
DR   KEGG; mpa:MAP_1573c; -.
DR   eggNOG; COG3957; Bacteria.
DR   HOGENOM; CLU_013954_2_0_11; -.
DR   OMA; LSTMDHC; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0016832; F:aldehyde-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.920; -; 1.
DR   HAMAP; MF_01403; Phosphoketolase; 1.
DR   InterPro; IPR023962; Phosphoketolase.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005593; Xul5P/Fru6P_PKetolase.
DR   InterPro; IPR018969; Xul5P/Fru6P_PKetolase_C.
DR   InterPro; IPR019790; Xul5P/Fru6P_PKetolase_CS.
DR   InterPro; IPR018970; Xul5P/Fru6P_PKetolase_N.
DR   InterPro; IPR019789; Xul5P/Fru6P_PKetolase_ThDP_BS.
DR   PANTHER; PTHR31273; PTHR31273; 1.
DR   Pfam; PF03894; XFP; 1.
DR   Pfam; PF09363; XFP_C; 1.
DR   Pfam; PF09364; XFP_N; 1.
DR   PIRSF; PIRSF017245; Phosphoketolase; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS60002; PHOSPHOKETOLASE_1; 1.
DR   PROSITE; PS60003; PHOSPHOKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome; Thiamine pyrophosphate.
FT   CHAIN           1..804
FT                   /note="Probable phosphoketolase"
FT                   /id="PRO_0000193881"
SQ   SEQUENCE   804 AA;  89278 MW;  37F05478C9912D7E CRC64;
     MSLETSTTTP AGSPLSDREL DLIDKYWRAA NYLSVGQIYL LDNPLLKEPL SAEHVKPRLL
     GHWGTTPGLN LVYAHLNRII RNRDADVIYV TGPGHGGPGL VANAYLEGTY SEVYTGIEED
     AEGLRKLFRQ FSFPGGIPSH VAAQTPGSIH EGGELGYALV HAYGAAFDNP YLVVACVIGD
     GEAETGPLAA GWHSNKFLNP VTDGAVLPIL ALNGYKIANP TVLARIPHTE LEALLRGYGY
     RPITVAGDDP TDVHRQLAAA LDEAFDGIAA IQGAARGGGE VQRPVWPMIV LRTPKGWTGP
     KVVDGKRVEG TWRSHQVPLA ETHDNPEHRA QLEEWLRSYG PEQLFDDDGR LRAELRALAP
     TGDRRMSANP HANGGLLLHD LDLPDFRDYA VPVSRPGSVT HEATRVLGTF LRDVIARNKD
     RFRMMGPDET ASNRLDAVYG ATEKVWLSAT EPDDEHLAPD GRVMEVLSEH LCQGWLEGYL
     LTGRHGLFNC YEAFVHIVDS MLNQHAKWLA TSRELPWRRP IASLNYLLTS HVWRQDHNGA
     SHQDPGFIDL VANKRAELTR VYLPPDGNTL LSVADHCLRS RDYINVIVAG KQPALAYLDM
     DAAIAHCTRG LGIWDWASTA RSIGAEPDVV LACAGDIPTL ETLAAADILR RELPDLAVRV
     VNVVDLMRLQ PDSEHPHGLP DREFDALFTR DRPVIFAYHG YPWLIHRLTY RRANHAQLHV
     RGFKERGTTT TPFDMVMLND LDRFHLVIDV LDRVEGLASR AAMLRQRMVD ARLAARMYTR
     EHGEDDPAIA NWTWEPSERN SRSE