ID   PHK_NOCFA               Reviewed;         822 AA.
AC   Q5Z066;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Probable phosphoketolase {ECO:0000255|HAMAP-Rule:MF_01403};
DE            EC=4.1.2.- {ECO:0000255|HAMAP-Rule:MF_01403};
GN   OrderedLocusNames=NFA_13300;
OS   Nocardia farcinica (strain IFM 10152).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=247156;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152;
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01403};
CC   -!- SIMILARITY: Belongs to the XFP family. {ECO:0000255|HAMAP-
CC       Rule:MF_01403}.
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DR   EMBL; AP006618; BAD56175.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5Z066; -.
DR   SMR; Q5Z066; -.
DR   STRING; 247156.NFA_13300; -.
DR   EnsemblBacteria; BAD56175; BAD56175; NFA_13300.
DR   KEGG; nfa:NFA_13300; -.
DR   eggNOG; COG3957; Bacteria.
DR   HOGENOM; CLU_013954_2_0_11; -.
DR   OMA; LSTMDHC; -.
DR   Proteomes; UP000006820; Chromosome.
DR   GO; GO:0016832; F:aldehyde-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.920; -; 1.
DR   HAMAP; MF_01403; Phosphoketolase; 1.
DR   InterPro; IPR023962; Phosphoketolase.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005593; Xul5P/Fru6P_PKetolase.
DR   InterPro; IPR018969; Xul5P/Fru6P_PKetolase_C.
DR   InterPro; IPR019790; Xul5P/Fru6P_PKetolase_CS.
DR   InterPro; IPR018970; Xul5P/Fru6P_PKetolase_N.
DR   InterPro; IPR019789; Xul5P/Fru6P_PKetolase_ThDP_BS.
DR   PANTHER; PTHR31273; PTHR31273; 1.
DR   Pfam; PF03894; XFP; 1.
DR   Pfam; PF09363; XFP_C; 1.
DR   Pfam; PF09364; XFP_N; 1.
DR   PIRSF; PIRSF017245; Phosphoketolase; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS60002; PHOSPHOKETOLASE_1; 1.
DR   PROSITE; PS60003; PHOSPHOKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome; Thiamine pyrophosphate.
FT   CHAIN           1..822
FT                   /note="Probable phosphoketolase"
FT                   /id="PRO_0000193883"
SQ   SEQUENCE   822 AA;  90907 MW;  3563E157CFB299C6 CRC64;
     MTQMASAGGD TSADNVGAHG GRTVAPVPYE LTEAAGPLDR AELAALDAWW RAANYLSVGQ
     IYLMANPLLT EPLRPEHIKP RLLGHFGTVP GLNLVWTHAN RVIRQRGLDA VFVAGPGHGG
     PGPNACAWLE GTYSELYSHI PRDGEGMAAL FAQFSFPGGV PSHCAPETPG SFHEGGELGY
     SLLHAYGAAL DNPDLTVFCV IGDGEAETGP LATSWHGNKF LNPGRDGAVL PILALNEYKI
     ANPTLFARIP EPELINLLEG YGHEPIVVAG DDPGVVHQRL AAAMDTCMNR IAQIQRAARD
     GADGSRPAWP MIVLRTPKGW TCPPVVDGDR VEGTFRAHQV PLPAARTDDG HRAVLEQWLR
     SYRPEELFDD RGRPVPELLA LAPEGDRRMS ANPVANGGAL VRDLRLPDWR EFGVEVKTPG
     GSTHEATRVL GGWLREVTRL NPHNFLTFAP DELASNRLQD ILEVTGRDWQ AEVGEYDVAL
     DRSGRVIEVL SEHICQGLLE GYLLTGRHGV FTCYEAFIHI VDAMFNQHAK WLDASAAVPW
     RRPLASLNYL LSSHVWRQDH NGFTHQDPGF LDVVLNKKPE IVRVYLPPDA NTLLSTYDHC
     LRSRHYVNVV VAGKQPQEDW LSVEQAAVHC ARGLGIWEWA CHNDDPGTTP DVVLACAGDV
     PTLETLAAAA ILRDRLPRLR VRVINVVDLM RLLPAEEHPH GLPDREFDTL FTTASPIIFA
     FHGYPWLIHR LTYRRTNHDG LHVRGYKEEG TTTTPFDMVM LNDLDRYHLV MDVIDRVPGL
     RETAAGLRQE MVDARWRARA WTREHGADIP VVADWTWPEP SR