ID   PHK_SCHPO               Reviewed;         825 AA.
AC   O74770;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Probable phosphoketolase;
DE            EC=4.1.2.-;
GN   ORFNames=SPBC24C6.09c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the XFP family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA21153.1; -; Genomic_DNA.
DR   PIR; T39973; T39973.
DR   RefSeq; NP_595963.1; NM_001021872.2.
DR   AlphaFoldDB; O74770; -.
DR   SMR; O74770; -.
DR   STRING; 4896.SPBC24C6.09c.1; -.
DR   MaxQB; O74770; -.
DR   PaxDb; O74770; -.
DR   EnsemblFungi; SPBC24C6.09c.1; SPBC24C6.09c.1:pep; SPBC24C6.09c.
DR   GeneID; 2540545; -.
DR   KEGG; spo:SPBC24C6.09c; -.
DR   PomBase; SPBC24C6.09c; -.
DR   VEuPathDB; FungiDB:SPBC24C6.09c; -.
DR   eggNOG; ENOG502QUUF; Eukaryota.
DR   HOGENOM; CLU_013954_2_0_1; -.
DR   InParanoid; O74770; -.
DR   OMA; EHMCQGF; -.
DR   PhylomeDB; O74770; -.
DR   PRO; PR:O74770; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0016832; F:aldehyde-lyase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.920; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005593; Xul5P/Fru6P_PKetolase.
DR   InterPro; IPR018969; Xul5P/Fru6P_PKetolase_C.
DR   InterPro; IPR019790; Xul5P/Fru6P_PKetolase_CS.
DR   InterPro; IPR018970; Xul5P/Fru6P_PKetolase_N.
DR   InterPro; IPR019789; Xul5P/Fru6P_PKetolase_ThDP_BS.
DR   PANTHER; PTHR31273; PTHR31273; 1.
DR   Pfam; PF03894; XFP; 1.
DR   Pfam; PF09363; XFP_C; 1.
DR   Pfam; PF09364; XFP_N; 1.
DR   PIRSF; PIRSF017245; Phosphoketolase; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   SUPFAM; SSF52922; SSF52922; 1.
DR   PROSITE; PS60002; PHOSPHOKETOLASE_1; 1.
DR   PROSITE; PS60003; PHOSPHOKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome; Thiamine pyrophosphate.
FT   CHAIN           1..825
FT                   /note="Probable phosphoketolase"
FT                   /id="PRO_0000193895"
SQ   SEQUENCE   825 AA;  92510 MW;  904CAFE0ECD097E3 CRC64;
     MATQNDIPNS TPEDLAKQVE IAEKHPDPPA MPSRLPDSLK TLEAKIDTSK ITDEEVANVH
     RFQRACDYLA ASLIFLSNGL YTGGDLEEKD IKTRLLGHWG TCPGLSIVYS HCNRIINKYD
     LNMLFVVGPG HGAPAILSAL FLEDSLGPFY PRYQFTKEGL NNLINTFSLP GGFPSHVNAE
     VPGAIHEGGE LGYALSVSYG AVLDRPDLIV TCVVGDGEAE TGPTATSWHA HKFLDPAESG
     AVIPVLELNG YKISERTIYG CMDDSELLSL FSGFGYEVAI VNDTPDQNRV MAATMDWAVE
     RIHDIQHRAR VNREEIKPRW PMIILRTPKG KGCPKYLNGK FLEGTFRAHQ VPLKLARTDT
     NQRNLLKDWL NSYNCQDFLD EHGLPTKGIT EHLPPREKRM GQRHETYNSY LPLKVPDWKK
     YGVKKGETTS ATSVVGQYLD ELLVTNDSTL RIFSPDELES NKLDGALKHS YRTMQTDPEL
     MAKRGRVTEV LSEHLCQGFM QGYTLTGRTA IFPSYEAFMT IVVSMLVQYS KFLKMGLETG
     WHGKFGSLNY VTSSTWARQE HNGFSHQSPR FITTMLSLKP GVSRVYFPPD ANCFLATVAR
     CMKSENTINL MVSSKNPQPA YLSVEEAEHH CKAGASVWKF ASTDNGENPD VVIAGVGNEI
     MFEVVKAAEM LQNDIPELRV RVINVTDLMV LSSLHPHGMN PAEFDSLFTK DRHVHFNYHG
     YVMDLKALLF DRIQGTRVTM EGYREEGTTT TPFNMMMCNN TSRYHVARMA LQHALHNPTV
     AVNCNMLCAK YAWKLEEIEN YIMENKDDPP EIYAAPVFKN KTSTL