ID   PHK_STRCO               Reviewed;         796 AA.
AC   Q8CK51;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 2.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Probable phosphoketolase {ECO:0000255|HAMAP-Rule:MF_01403};
DE            EC=4.1.2.- {ECO:0000255|HAMAP-Rule:MF_01403};
GN   OrderedLocusNames=SCO0617; ORFNames=SCF55.41c, SCF56.01c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01403};
CC   -!- SIMILARITY: Belongs to the XFP family. {ECO:0000255|HAMAP-
CC       Rule:MF_01403}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAD55268.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL939106; CAD55268.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_733508.1; NC_003888.3.
DR   RefSeq; WP_011027249.1; NC_003888.3.
DR   AlphaFoldDB; Q8CK51; -.
DR   SMR; Q8CK51; -.
DR   STRING; 100226.SCO0617; -.
DR   GeneID; 1096040; -.
DR   KEGG; sco:SCO0617; -.
DR   PATRIC; fig|100226.15.peg.598; -.
DR   eggNOG; COG3957; Bacteria.
DR   HOGENOM; CLU_013954_2_0_11; -.
DR   InParanoid; Q8CK51; -.
DR   PhylomeDB; Q8CK51; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0016832; F:aldehyde-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.920; -; 1.
DR   HAMAP; MF_01403; Phosphoketolase; 1.
DR   InterPro; IPR023962; Phosphoketolase.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005593; Xul5P/Fru6P_PKetolase.
DR   InterPro; IPR018969; Xul5P/Fru6P_PKetolase_C.
DR   InterPro; IPR019790; Xul5P/Fru6P_PKetolase_CS.
DR   InterPro; IPR018970; Xul5P/Fru6P_PKetolase_N.
DR   InterPro; IPR019789; Xul5P/Fru6P_PKetolase_ThDP_BS.
DR   PANTHER; PTHR31273; PTHR31273; 1.
DR   Pfam; PF03894; XFP; 1.
DR   Pfam; PF09363; XFP_C; 1.
DR   Pfam; PF09364; XFP_N; 1.
DR   PIRSF; PIRSF017245; Phosphoketolase; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS60002; PHOSPHOKETOLASE_1; 1.
DR   PROSITE; PS60003; PHOSPHOKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome; Thiamine pyrophosphate.
FT   CHAIN           1..796
FT                   /note="Probable phosphoketolase"
FT                   /id="PRO_0000193891"
SQ   SEQUENCE   796 AA;  88176 MW;  6B2150B492BC02B3 CRC64;
     MSVDTQQAPP EPTDEELAGL DAHWRAANYL AVGQIYLMAN PLLTDPLRPE HVKPRLLGHW
     GTSPGLNLVH THLNRVIKAR DLDALCVWGP GHGGPAVLAN AWLEGSYTET YPDITRDAAG
     MARLFKQFSF PGGVPSHVAP ETPGSIHEGG ELGYALSHAY GAAFDHPDLV VACVIGDGEA
     ETGPLATSWH SNKFLDPVHD GAVLPILHLN GYKIANPTVL ARLPETELDE LLRGYGHDPV
     HVTGDDPAAV HRATARAMDT ALDRIAAIQR AAREEGATGR PRWPMIVLRT PKGWTGPAEV
     DGLPVENTWR AHQVPLSAVR TNPEHLAQLE RWLRSYRPEE LFDDAGAPRP AVLAAIPEGP
     RRLGATPYAN GGLLLRELPV PPLEKYAVPV GEPGASTHEP TRVLGDLLRD VMAATTDRRD
     FRLVGPDETA SNRLQAVYAA TGKAWQERTL PVDEDLDRHG RVMEILSEHT CQGWLEGYLL
     TGRHGLFSCY EAFVHIVDSM VNQHVKWLRV TRRLPWRAPI ASLNYLLTSH VWRQDHNGFS
     HQEPGFVDHI LNKSPEAVRV YLPPDANTLL SVADHALRSR DYVNVIVAGK QPCFDWLTMD
     QAKAHCARGA GIWDWAGTED GSREPDVVLA CAGDVPTLEI LAAAQLIRHH LPELAVRVVN
     VVDIARLLPS GEHPHGMSDF EYDGLFTADK PVIFAYHGYP WLIHRLAYRR TGHAHLHVRG
     YKEIGTTTTP FDMVVGNDLD RYRLVMDVID RVPGLAVRAA AVRQRMEDAR QRHHDWIREH
     GVDLPEVADW TWEAPR