PHL12_ARATH
ID PHL12_ARATH Reviewed; 255 AA.
AC Q84WF5; Q9C804;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Phytolongin Phyl1.2 {ECO:0000303|PubMed:19889231};
GN Name=PHYL1.2 {ECO:0000303|PubMed:19889231};
GN OrderedLocusNames=At1g33475 {ECO:0000312|Araport:AT1G33475};
GN ORFNames=F10C21.23 {ECO:0000312|EMBL:AAG51221.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19889231; DOI=10.1186/1471-2164-10-510;
RA Vedovato M., Rossi V., Dacks J.B., Filippini F.;
RT "Comparative analysis of plant genomes allows the definition of the
RT 'Phytolongins': a novel non-SNARE longin domain protein family.";
RL BMC Genomics 10:510-510(2009).
CC -!- FUNCTION: Non-SNARE longin protein involved in membrane-trafficking
CC machinery. {ECO:0000305|PubMed:19889231}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein
CC {ECO:0000250|UniProtKB:Q12255}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG51221.1; Type=Erroneous gene model prediction; Note=The predicted gene At1g33480 has been split into 2 genes: At1g33475 and At1g33480.; Evidence={ECO:0000305};
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DR EMBL; AC051630; AAG51221.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31598.1; -; Genomic_DNA.
DR EMBL; BT003879; AAO41928.1; -; mRNA.
DR EMBL; BT015121; AAT71993.1; -; mRNA.
DR PIR; F86458; F86458.
DR RefSeq; NP_683346.3; NM_148505.4.
DR AlphaFoldDB; Q84WF5; -.
DR SMR; Q84WF5; -.
DR STRING; 3702.AT1G33475.1; -.
DR iPTMnet; Q84WF5; -.
DR PaxDb; Q84WF5; -.
DR PRIDE; Q84WF5; -.
DR ProteomicsDB; 236143; -.
DR EnsemblPlants; AT1G33475.1; AT1G33475.1; AT1G33475.
DR GeneID; 840241; -.
DR Gramene; AT1G33475.1; AT1G33475.1; AT1G33475.
DR KEGG; ath:AT1G33475; -.
DR Araport; AT1G33475; -.
DR TAIR; locus:504956331; AT1G33475.
DR eggNOG; KOG0800; Eukaryota.
DR HOGENOM; CLU_088757_0_0_1; -.
DR OMA; GSTVHYC; -.
DR OrthoDB; 1196118at2759; -.
DR PhylomeDB; Q84WF5; -.
DR PRO; PR:Q84WF5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q84WF5; baseline and differential.
DR Genevisible; Q84WF5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd14824; Longin; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR044783; PHYL.
DR PANTHER; PTHR47461; PTHR47461; 1.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..255
FT /note="Phytolongin Phyl1.2"
FT /id="PRO_0000206784"
FT TRANSMEM 227..247
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT DOMAIN 12..115
FT /note="Longin"
FT REGION 151..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 255 AA; 28773 MW; 39DB121E676B2E32 CRC64;
MGSIQNTVHY CCVSRDNQIM YAYNNAGDHR NNESLAALCL EKTPPFHKWY FETRGKKTFG
FLMKDDFVYF AIVDDVFKKS SVLDFLEKLR DELKEANKKN SRGSFSGSIS FSNVQDQIVR
RLIASLEFDH TCLPLSSPSI DGAEQSYASN SKAPLLGRSN KQDKKKGRDH AHSLRGIEIE
EHRKSNDRGN VTECSNASSE SATYVPRRGR SGGSQSIERK WRRQVKIVLA IDIAICLTLL
GVWLAICHGI ECTRS
