ID   PHL1_LEPIN              Reviewed;         597 AA.
AC   P59115;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2002, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Sphingomyelinase C 1;
DE            EC=3.1.4.12;
DE   AltName: Full=Sphingomyelin phosphodiesterase 1;
DE            Short=SMase 1;
DE   Flags: Precursor;
GN   Name=sph1; OrderedLocusNames=LA_1027;
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=189518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601;
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X.,
RA   Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X.,
RA   Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F., Zhang Y., Zhu G.-F.,
RA   Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y.,
RA   Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I.,
RA   Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) +
CC         phosphocholine; Xref=Rhea:RHEA:19253, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639,
CC         ChEBI:CHEBI:295975; EC=3.1.4.12;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN48226.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE010300; AAN48226.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_711208.2; NC_004342.2.
DR   RefSeq; WP_000629004.1; NC_004342.2.
DR   AlphaFoldDB; P59115; -.
DR   SMR; P59115; -.
DR   EnsemblBacteria; AAN48226; AAN48226; LA_1027.
DR   KEGG; lil:LA_1027; -.
DR   PATRIC; fig|189518.3.peg.1024; -.
DR   HOGENOM; CLU_489836_0_0_12; -.
DR   InParanoid; P59115; -.
DR   OMA; WPIEEKV; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:UniProtKB-EC.
DR   CDD; cd09078; nSMase; 1.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR038772; SMPD2-like.
DR   InterPro; IPR017766; Sphingomyelinase/PLipase_C.
DR   PANTHER; PTHR12393; PTHR12393; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
DR   TIGRFAMs; TIGR03395; sphingomy; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..37
FT                   /evidence="ECO:0000255"
FT   CHAIN           38..597
FT                   /note="Sphingomyelinase C 1"
FT                   /id="PRO_0000022050"
FT   REGION          64..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..119
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   597 AA;  68192 MW;  2601745BC37DCEE9 CRC64;
     MITKRNIPPC KKNWKYKKKS ISLTLITICY MFLFLTSCKP GKKNSINLLL LLLNTLDNKN
     VNEKIEDSTN TDPSSNVNEE DENSINANAN DNAPSDSDSS NPRSPDKNPV NPTSPNSSSA
     DIGIKILSHS IFMAPTNLSS WGDLGQEERA QRIASSSYIK NQDIIVFEGL SHNNAEKILL
     EKIRSEYPYQ TNVVGRTKKG WNATLGAYTT SPMANGGVII VSKWPIEEKV QYIFNNSNCG
     QDQYYNKGFA YVKINKDGKK FHVIGTQLQA REPDCFNSGE TIRKLQLNDI KSFIDSKDIP
     KDETVLITGD LNIIKGSNEY FDMISKLNVN EPRYVGVPFT LDTKTNALAA YYYEKEKPIY
     LDYILVSKLH AQPPVWQNLA YDPISNTTWK RSDGYTSYEF SDRYPVYGFI YADSSTPTKS
     GHKRKYDQVS FQSTFNRKFI QADHNKKDGW LKADTRIKTD FTKFNLLQEN VSESNPSCMN
     SGSVRIESSY YLNYYWNWFI GAASGDYGYY TKFNNGSDSL GIKNLDNGCL KDGSRVAFYD
     WDTIGGGYYY LTVWDKGSWK EHLFLWVQSF LSSREIFYLH LDSNPPKDWS KDLIYHH