PHL21_ARATH
ID PHL21_ARATH Reviewed; 260 AA.
AC Q9STP2;
DT 09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Phytolongin Phyl2.1 {ECO:0000303|PubMed:19889231};
GN Name=PHYL2.1 {ECO:0000303|PubMed:19889231};
GN OrderedLocusNames=At4g27840 {ECO:0000312|Araport:AT4G27840};
GN ORFNames=T27E11.80 {ECO:0000312|EMBL:CAB43972.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19889231; DOI=10.1186/1471-2164-10-510;
RA Vedovato M., Rossi V., Dacks J.B., Filippini F.;
RT "Comparative analysis of plant genomes allows the definition of the
RT 'Phytolongins': a novel non-SNARE longin domain protein family.";
RL BMC Genomics 10:510-510(2009).
CC -!- FUNCTION: Non-SNARE longin protein involved in membrane-trafficking
CC machinery. {ECO:0000305|PubMed:19889231}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type IV
CC membrane protein {ECO:0000250|UniProtKB:Q12255}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR EMBL; AL078579; CAB43972.1; -; Genomic_DNA.
DR EMBL; AL161571; CAB81433.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85399.1; -; Genomic_DNA.
DR EMBL; AY069904; AAL47455.1; -; mRNA.
DR EMBL; AY142001; AAM98265.1; -; mRNA.
DR PIR; T09023; T09023.
DR RefSeq; NP_194513.1; NM_118922.5.
DR AlphaFoldDB; Q9STP2; -.
DR SMR; Q9STP2; -.
DR STRING; 3702.AT4G27840.1; -.
DR iPTMnet; Q9STP2; -.
DR PaxDb; Q9STP2; -.
DR PRIDE; Q9STP2; -.
DR ProteomicsDB; 236676; -.
DR EnsemblPlants; AT4G27840.1; AT4G27840.1; AT4G27840.
DR GeneID; 828897; -.
DR Gramene; AT4G27840.1; AT4G27840.1; AT4G27840.
DR KEGG; ath:AT4G27840; -.
DR Araport; AT4G27840; -.
DR TAIR; locus:2137365; AT4G27840.
DR eggNOG; ENOG502RYW5; Eukaryota.
DR HOGENOM; CLU_088757_0_0_1; -.
DR InParanoid; Q9STP2; -.
DR OMA; NPTQHCL; -.
DR OrthoDB; 1482649at2759; -.
DR PhylomeDB; Q9STP2; -.
DR PRO; PR:Q9STP2; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9STP2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd14824; Longin; 1.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR044783; PHYL.
DR PANTHER; PTHR47461; PTHR47461; 1.
PE 2: Evidence at transcript level;
KW Membrane; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..260
FT /note="Phytolongin Phyl2.1"
FT /id="PRO_0000434813"
FT TRANSMEM 231..251
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT DOMAIN 12..114
FT /note="Longin"
SQ SEQUENCE 260 AA; 29203 MW; 6482A1D19C3A3C47 CRC64;
MTSNQRMLFY SCIAKGTVIL AEFASKEEPG IEDLALRCIE NVPPHHSMIS HTVHKRTYAL
IIDGLFSYFA ILDEVVAKSE SVWLFNRLKS ATESLMEDGS TADSLDNPTQ HCLQSKLDPV
FAEIAAIGGN HNKDLELEFG SPRSIAREIK SNNQSLDSSK GRKGGALMPL LGKPLRVLKN
KKRLQTEAKS EGHWNEKKMD LGGGGKGVRN GLIHDHHHRQ KAKQIWRKHV WIVLMFDLCI
CLVLFGIWLW ICQGFQCIDG
