PHL22_ARATH
ID PHL22_ARATH Reviewed; 272 AA.
AC Q9LVV3; Q84VZ3;
DT 09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Phytolongin Phyl2.2 {ECO:0000303|PubMed:19889231};
GN Name=PHYL2.2 {ECO:0000303|PubMed:19889231};
GN OrderedLocusNames=At5g52990 {ECO:0000312|Araport:AT5G52990};
GN ORFNames=MNB8.5 {ECO:0000312|EMBL:BAA97139.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19889231; DOI=10.1186/1471-2164-10-510;
RA Vedovato M., Rossi V., Dacks J.B., Filippini F.;
RT "Comparative analysis of plant genomes allows the definition of the
RT 'Phytolongins': a novel non-SNARE longin domain protein family.";
RL BMC Genomics 10:510-510(2009).
CC -!- FUNCTION: Non-SNARE longin protein involved in membrane-trafficking
CC machinery. {ECO:0000305|PubMed:19889231}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type IV
CC membrane protein {ECO:0000250|UniProtKB:Q12255}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR EMBL; AB018116; BAA97139.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96287.1; -; Genomic_DNA.
DR EMBL; BT004599; AAO42845.1; -; mRNA.
DR EMBL; AK227969; BAE99936.1; -; mRNA.
DR RefSeq; NP_200111.1; NM_124678.5.
DR AlphaFoldDB; Q9LVV3; -.
DR SMR; Q9LVV3; -.
DR STRING; 3702.AT5G52990.1; -.
DR iPTMnet; Q9LVV3; -.
DR PaxDb; Q9LVV3; -.
DR PRIDE; Q9LVV3; -.
DR ProteomicsDB; 235105; -.
DR EnsemblPlants; AT5G52990.1; AT5G52990.1; AT5G52990.
DR GeneID; 835378; -.
DR Gramene; AT5G52990.1; AT5G52990.1; AT5G52990.
DR KEGG; ath:AT5G52990; -.
DR Araport; AT5G52990; -.
DR TAIR; locus:2168382; AT5G52990.
DR eggNOG; ENOG502RYW5; Eukaryota.
DR HOGENOM; CLU_088757_0_0_1; -.
DR InParanoid; Q9LVV3; -.
DR OMA; IWLWVCR; -.
DR OrthoDB; 1482649at2759; -.
DR PhylomeDB; Q9LVV3; -.
DR PRO; PR:Q9LVV3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LVV3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd14824; Longin; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR044783; PHYL.
DR PANTHER; PTHR47461; PTHR47461; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..272
FT /note="Phytolongin Phyl2.2"
FT /id="PRO_0000434814"
FT TRANSMEM 243..263
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT DOMAIN 12..116
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT CONFLICT 74
FT /note="D -> G (in Ref. 3; AAO42845 and 4; BAE99936)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 272 AA; 30457 MW; 848BA7F806BBE6DA CRC64;
MISNPSLLSY TCIAKGTVVL AEFVSRQEPG IEAIALRCIE NTPPHHSMFS HTVHKKTYTF
AIDDDSFVYF SISDESMEKP ESFWVLNRLR SAIEDLIKDG GSDVETLINP VSHCLQLKLD
PVFAEIVGVV DLELLDMDLV GSPRSVARES RNPSIDSSKG RRAALMPLLG KPLKALKKKK
RLHNEAKGGD SCEVGSIQEI SEKNVDLCGN GNNGVLRKEL RNGLLSDHHH RQKAKQIWKK
HVWVVLMFDF CICAVLFGIW LWICEGFQCI QG
