ID   PHLA2_BOVIN             Reviewed;         142 AA.
AC   Q0VC85;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Pleckstrin homology-like domain family A member 2;
DE   AltName: Full=Imprinted in placenta and liver protein;
GN   Name=PHLDA2; Synonyms=IPL;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Placenta;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in regulating placenta growth. May act via its
CC       PH domain that competes with other PH domain-containing proteins,
CC       thereby preventing their binding to membrane lipids (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- DOMAIN: The PH domain binds phosphoinositides with a broad specificity.
CC       It may compete with the PH domain of some other proteins, thereby
CC       interfering with their binding to phosphatidylinositol 4,5-bisphosphate
CC       (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PHLDA2 family. {ECO:0000305}.
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DR   EMBL; BC120298; AAI20299.1; -; mRNA.
DR   RefSeq; NP_001069989.1; NM_001076521.2.
DR   AlphaFoldDB; Q0VC85; -.
DR   SMR; Q0VC85; -.
DR   STRING; 9913.ENSBTAP00000041685; -.
DR   PaxDb; Q0VC85; -.
DR   PRIDE; Q0VC85; -.
DR   Ensembl; ENSBTAT00000044171; ENSBTAP00000041685; ENSBTAG00000031194.
DR   GeneID; 618810; -.
DR   KEGG; bta:618810; -.
DR   CTD; 7262; -.
DR   VEuPathDB; HostDB:ENSBTAG00000031194; -.
DR   VGNC; VGNC:32836; PHLDA2.
DR   eggNOG; ENOG502RXZA; Eukaryota.
DR   GeneTree; ENSGT00440000039564; -.
DR   InParanoid; Q0VC85; -.
DR   OMA; DNCWNAV; -.
DR   OrthoDB; 1412115at2759; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000031194; Expressed in placenta and 73 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1901981; F:phosphatidylinositol phosphate binding; IEA:InterPro.
DR   GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
DR   GO; GO:0001890; P:placenta development; IBA:GO_Central.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0030334; P:regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0045995; P:regulation of embryonic development; IEA:Ensembl.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0070873; P:regulation of glycogen metabolic process; IEA:Ensembl.
DR   GO; GO:1903547; P:regulation of growth hormone activity; IEA:Ensembl.
DR   GO; GO:0060721; P:regulation of spongiotrophoblast cell proliferation; IEA:Ensembl.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR042832; PHLA1/2/3.
DR   PANTHER; PTHR15478; PTHR15478; 1.
DR   SMART; SM00233; PH; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Phosphoprotein; Reference proteome.
FT   CHAIN           1..142
FT                   /note="Pleckstrin homology-like domain family A member 2"
FT                   /id="PRO_0000369386"
FT   DOMAIN          7..99
FT                   /note="PH"
FT   MOD_RES         3
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q53GA4"
SQ   SEQUENCE   142 AA;  15868 MW;  E58E4E186B4E9714 CRC64;
     MRSPGEVLRE GELEKRSDSL LQVWKKKRGV LTTDRLRLFP TGPGARPKEL RFHSILKVDC
     VERTGKYVYF TIVTTDRKEI DFRCAGESYW NASITLALID FQNRRAMQDF RSRRERAAAA
     AAAAAAAAAA EQEPEAGPGG QP