ID   PHLA2_DANRE             Reviewed;         136 AA.
AC   Q503L1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Pleckstrin homology-like domain family A member 2;
DE   AltName: Full=Imprinted in placenta and liver protein;
GN   Name=phlda2; Synonyms=ipl; ORFNames=zgc:110459;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in regulating placenta growth. May act via its
CC       PH domain that competes with other PH domain-containing proteins,
CC       thereby preventing their binding to membrane lipids (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- DOMAIN: The PH domain binds phosphoinositides with a broad specificity.
CC       It may compete with the PH domain of some other proteins, thereby
CC       interfering with their binding to phosphatidylinositol 4,5-bisphosphate
CC       (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PHLDA2 family. {ECO:0000305}.
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DR   EMBL; BC095282; AAH95282.1; -; mRNA.
DR   EMBL; BC155735; AAI55736.1; -; mRNA.
DR   RefSeq; NP_001018432.1; NM_001020596.1.
DR   AlphaFoldDB; Q503L1; -.
DR   SMR; Q503L1; -.
DR   STRING; 7955.ENSDARP00000062929; -.
DR   PaxDb; Q503L1; -.
DR   Ensembl; ENSDART00000062930; ENSDARP00000062929; ENSDARG00000042874.
DR   Ensembl; ENSDART00000191331; ENSDARP00000147363; ENSDARG00000042874.
DR   Ensembl; ENSDART00000192216; ENSDARP00000156613; ENSDARG00000114844.
DR   GeneID; 553622; -.
DR   KEGG; dre:553622; -.
DR   CTD; 7262; -.
DR   ZFIN; ZDB-GENE-050522-73; phlda2.
DR   eggNOG; ENOG502RXZA; Eukaryota.
DR   GeneTree; ENSGT00440000039564; -.
DR   HOGENOM; CLU_062639_1_0_1; -.
DR   InParanoid; Q503L1; -.
DR   OMA; DNCWNAV; -.
DR   OrthoDB; 1412115at2759; -.
DR   PhylomeDB; Q503L1; -.
DR   TreeFam; TF332320; -.
DR   PRO; PR:Q503L1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 25.
DR   Bgee; ENSDARG00000042874; Expressed in heart and 21 other tissues.
DR   ExpressionAtlas; Q503L1; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1901981; F:phosphatidylinositol phosphate binding; IEA:InterPro.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR042832; PHLA1/2/3.
DR   PANTHER; PTHR15478; PTHR15478; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..136
FT                   /note="Pleckstrin homology-like domain family A member 2"
FT                   /id="PRO_0000369387"
FT   DOMAIN          9..103
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
SQ   SEQUENCE   136 AA;  15709 MW;  F2EDEEE41CCD6994 CRC64;
     MTGSDISHIL KEGELEKRSD NLLQFWKRKT CVLTTDSLNI YTDQQKKNKS KELKLQSIKK
     VDCVEHTGKF VYFTIVTTDN KEIDFRCSDE KNCWNAVIAI ALVNFQNRKA IQGFKTQKES
     ENTSLGQQER CMARAP