ID   PHLA2_XENLA             Reviewed;         125 AA.
AC   A1L2W9;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Pleckstrin homology-like domain family A member 2;
DE   AltName: Full=Imprinted in placenta and liver protein;
GN   Name=phlda2; Synonyms=ipl;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in regulating placenta growth. May act via its
CC       PH domain that competes with other PH domain-containing proteins,
CC       thereby preventing their binding to membrane lipids (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- DOMAIN: The PH domain binds phosphoinositides with a broad specificity.
CC       It may compete with the PH domain of some other proteins, thereby
CC       interfering with their binding to phosphatidylinositol 4,5-bisphosphate
CC       (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PHLDA2 family. {ECO:0000305}.
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DR   EMBL; BC129749; AAI29750.1; -; mRNA.
DR   RefSeq; NP_001091206.1; NM_001097737.1.
DR   AlphaFoldDB; A1L2W9; -.
DR   SMR; A1L2W9; -.
DR   PRIDE; A1L2W9; -.
DR   GeneID; 100036975; -.
DR   KEGG; xla:100036975; -.
DR   CTD; 100036975; -.
DR   Xenbase; XB-GENE-6255844; phlda2.L.
DR   OrthoDB; 1412115at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 100036975; Expressed in kidney and 11 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1901981; F:phosphatidylinositol phosphate binding; IEA:InterPro.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR042832; PHLA1/2/3.
DR   PANTHER; PTHR15478; PTHR15478; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..125
FT                   /note="Pleckstrin homology-like domain family A member 2"
FT                   /id="PRO_0000369389"
FT   DOMAIN          7..100
FT                   /note="PH"
SQ   SEQUENCE   125 AA;  14327 MW;  0ED59A87C608A0CE CRC64;
     MQPGQAVIME GELEKRSDNL LQFWRKKLCV LTKESLSLFP DAQKKSKCKE LKFQSIKKVD
     CVERTGKYIY FTIVTTDNKE IDFRCLDQSA WNAAITLALI EFQNKAAVQS FRSQQGTNTR
     VAPCV