ID   PHLP2_DICDI             Reviewed;         239 AA.
AC   Q71A38; Q54N77;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Phosducin-like protein 2;
GN   Name=phlp2; ORFNames=DDB_G0285433;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND THIOREDOXIN FOLD REGION.
RX   PubMed=14517243; DOI=10.1093/emboj/cdg508;
RA   Blaauw M., Knol J.C., Kortholt A., Roelofs J., Ruchira X., Postma M.,
RA   Visser A.J.W.G., van Haastert P.J.M.;
RT   "Phosducin-like proteins in Dictyostelium discoideum: implications for the
RT   phosducin family of proteins.";
RL   EMBO J. 22:5047-5057(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the phosducin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF540059; AAQ11193.1; -; mRNA.
DR   EMBL; AAFI02000079; EAL64554.1; -; Genomic_DNA.
DR   RefSeq; XP_638066.1; XM_632974.1.
DR   AlphaFoldDB; Q71A38; -.
DR   SMR; Q71A38; -.
DR   STRING; 44689.DDB0191251; -.
DR   PaxDb; Q71A38; -.
DR   EnsemblProtists; EAL64554; EAL64554; DDB_G0285433.
DR   GeneID; 8625112; -.
DR   KEGG; ddi:DDB_G0285433; -.
DR   dictyBase; DDB_G0285433; phlp2.
DR   eggNOG; KOG3170; Eukaryota.
DR   HOGENOM; CLU_072604_0_0_1; -.
DR   InParanoid; Q71A38; -.
DR   OMA; QKPDYSR; -.
DR   PhylomeDB; Q71A38; -.
DR   PRO; PR:Q71A38; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0019954; P:asexual reproduction; IMP:dictyBase.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   InterPro; IPR024253; Phosducin_thioredoxin-like_dom.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF02114; Phosducin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..239
FT                   /note="Phosducin-like protein 2"
FT                   /id="PRO_0000326488"
FT   REGION          42..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          90..239
FT                   /note="Thioredoxin fold"
FT   REGION          212..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          26..87
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        42..59
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..231
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        163
FT                   /note="T -> P (in Ref. 1; AAQ11193)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   239 AA;  27247 MW;  78E8C487D0E2CD51 CRC64;
     MGLGKTEWED IQIKYGNMEA PPKQLTEDEL FDLIKEAAEM ATEAEKNEKL ENASLKDLKD
     MEDDEDEDVL EQLRKKRIQQ MKVEAELNKF GELKEISEPS YKSEVTECKG VMVVVHLFKN
     GIPQCQLVNQ HLTILAKKFK ATKFVKIRSE EAIHNYPDKN LPTILVYFNG DIVGQIITLR
     ATGGDATTVN DIEWQLKQAH AIKSDLQEDP RITLARKKSQ KSRYSKADSD ESDNSDSDD