PHLPP_CAEEL
ID PHLPP_CAEEL Reviewed; 1126 AA.
AC Q09564;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 25-APR-2018, sequence version 3.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Protein phosphatase PHLPP-like protein;
DE EC=3.1.3.16 {ECO:0000250|UniProtKB:Q6ZVD8};
DE AltName: Full=PH domain and leucine-rich repeat-containing protein phosphatase phlp-2 {ECO:0000312|WormBase:F43C1.1};
GN Name=phlp-2 {ECO:0000312|WormBase:F43C1.1};
GN ORFNames=F43C1.1 {ECO:0000312|WormBase:F43C1.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Probable protein phosphatase. {ECO:0000250|UniProtKB:Q6ZVD8}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; EC=3.1.3.16;
CC Evidence={ECO:0000250|UniProtKB:Q6ZVD8};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000250|UniProtKB:Q6ZVD8};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
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DR EMBL; BX284603; CAA87056.2; -; Genomic_DNA.
DR PIR; T22117; T22117.
DR AlphaFoldDB; Q09564; -.
DR SMR; Q09564; -.
DR BioGRID; 50450; 4.
DR STRING; 6239.F43C1.1; -.
DR PaxDb; Q09564; -.
DR EnsemblMetazoa; F43C1.1.1; F43C1.1.1; WBGene00009647.
DR UCSC; F43C1.1; c. elegans.
DR WormBase; F43C1.1; CE51952; WBGene00009647; phlp-2.
DR eggNOG; KOG0618; Eukaryota.
DR GeneTree; ENSGT00960000189222; -.
DR HOGENOM; CLU_010874_0_0_1; -.
DR InParanoid; Q09564; -.
DR PhylomeDB; Q09564; -.
DR Reactome; R-CEL-6803207; TP53 Regulates Transcription of Caspase Activators and Caspases.
DR PRO; PR:Q09564; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00009647; Expressed in embryo and 3 other tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.60.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR036457; PPM-type_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase_dom.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF81606; SSF81606; 1.
DR PROSITE; PS51450; LRR; 18.
DR PROSITE; PS51746; PPM_2; 1.
PE 3: Inferred from homology;
KW Hydrolase; Leucine-rich repeat; Manganese; Metal-binding;
KW Protein phosphatase; Reference proteome; Repeat.
FT CHAIN 1..1126
FT /note="Protein phosphatase PHLPP-like protein"
FT /evidence="ECO:0000305"
FT /id="PRO_0000057786"
FT REPEAT 56..79
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 192..213
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 227..250
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 251..276
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 286..309
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 310..332
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 333..355
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 356..378
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 380..403
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 419..445
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 451..476
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 483..506
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 507..529
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 531..551
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 552..574
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 576..601
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 623..646
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 648..672
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 674..692
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 693..714
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REPEAT 716..743
FT /note="LRR 21"
FT /evidence="ECO:0000255"
FT DOMAIN 761..987
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01082"
FT REGION 1038..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1062
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1126 AA; 128125 MW; 76A5EC60808F9672 CRC64;
MNNEQLQSTS SSPSTLLKPI EKKSRFLRLY SSDGQRSTRI ECDEHTTCAQ ICQQFSCDVI
TLQIGNYHFR QLKSDTSPLA ILQDFCRILT MSDENLETES TSKALEDILS YTDSPAFRHI
FSFFLGRPRI RAKSTLNLDI LSEEVVIRKG KLIHTWQNAR AVFYNSNIRL QTKNNQDEAL
QIRNMKVDVH ESKRGRALRL KDDDVCYLII FQRPNILEAW LTRAQQVEKS NHVDASDEQL
TLIPEQILNN EARVQILNLR RNSLISRPPT EKSMAPLGYI DDLYRVHSLQ VIDLSANQIL
SFPIQLTLLS HLRQLNLSSN YISSVPSECS NMRRLQYLNL SNNQLDTLPD SISELQNLQS
LDISFNQFSQ IPPCLFHLTL EMWRLAGNNI EKIDRVGEMQ IQKIDLRRNV LDTSFRLDIE
NITHLDLRDN SMISTVHLTN LRFLKVIHCE RLQLSSLHLS GESLTHVYAD HNLLDSLVVM
PLPQNLQTLS LSFNHFRNLP DWISDCPNLT FLRANNNSLV ALPERIFYSQ SLRSIFAFIN
EIEHIPDFGE ENCLETLILY KNKLSSLPKH FFSILPRLRQ LNISSNFIEL LPYFDGSSFC
RLQILRCANN YLTENSVPVI VNMKHLKIID LSHNRLNSFD DSALSSLELL EDLNLSSNRL
TRLADCLALL PCLQVLRAHS NQLVHVPEFR ASNQLHTIDV SSNNISLGTL QFKAPPNLRH
FDVTCNSGDF DTENFPENAK MHSKMNTINI SEGSQNLFGF QIGVSGSRGM KNKQCIRQVR
VENTFGFIDG GSNSYMSSSI CRFMTSYLKE NVSMDIRSIL LRCHCELGEE GERLGASVMI
IRVHEKRLEI ASTGTMSAAI ARNQKLKMII NGRYEIDDDE YSRIREAHGF VDEENRINGV
IGSSRQIGHF STFPVVLPTH SYRNIQLNEQ IEGLIVGNNM IWNMLSIDDL NSTFHNNRSP
IVVAKKIQDQ LQSYDYGGNS NILVLRRIKP QMTFNGFSTS STKNQVTPDI AIPKIDEQLV
LAVPALILPE YHPSPPVPPP IPAIRHRTPS PPPPPLPSST PPPVSSEHEE INVRQSSTLS
GGYTLSIDRF YSSSSTVSSR KQFNETRDLL SKSLKLSPPN TVTFNI
