ID   PHM6_PYRSX              Reviewed;         461 AA.
AC   A0A2Z5XAK7;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2018, sequence version 1.
DT   03-AUG-2022, entry version 14.
DE   RecName: Full=Transcription factor phm6 {ECO:0000303|PubMed:29972614};
DE   AltName: Full=Phomasetin biosynthesis cluster protein 6 {ECO:0000303|PubMed:29972614};
GN   Name=phm6 {ECO:0000303|PubMed:29972614};
OS   Pyrenochaetopsis sp.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pyrenochaetopsidaceae;
OC   Pyrenochaetopsis; unclassified Pyrenochaetopsis.
OX   NCBI_TaxID=1756125;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=RK10-F058;
RX   PubMed=29972614; DOI=10.1002/anie.201805050;
RA   Kato N., Nogawa T., Takita R., Kinugasa K., Kanai M., Uchiyama M.,
RA   Osada H., Takahashi S.;
RT   "Control of the stereochemical course of [4+2] cycloaddition during trans-
RT   decalin formation by Fsa2-family enzymes.";
RL   Angew. Chem. Int. Ed. 57:9754-9758(2018).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of the trans-fused decalin-
CC       containing tetramic acid phomasetin. {ECO:0000269|PubMed:29972614}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; LC361337; BBC43189.1; -; Genomic_DNA.
DR   SMR; A0A2Z5XAK7; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..461
FT                   /note="Transcription factor phm6"
FT                   /id="PRO_0000453354"
FT   DNA_BIND        18..50
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          55..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   461 AA;  50653 MW;  897C00E14362E0A9 CRC64;
     MASEQNSPDA LLSIRSSCNR CRNHKLKCVV TEAPNGTACC QRCIRAMVPC KFGRRERKKR
     GSSPRVVPQS PWMHSPWETT STSMQSIYPN TEAMDVGRAD ALVVHGTNAF PPPANVPAEQ
     SLTGDHSAIL TPGSMNMGIF NHLSLDANNL EADDIHAYKF PHGQLHEAHH TQYWHFQADE
     WRMDHPNDDS HSDYSATSSS KAATAALLQL AADLQERLDA LENEPSWRRK NASMDKYPIG
     SVLQLSSKLQ QLGRCLQTDD SSSTQSESSR SRASVGATSS VHRLQMPVLE SGTSDACLNV
     SHLTSTTRFD TSVSLMLLSC FVTLLQISTG VLGHFQDYLH AHPKTRARTL SMSAAQSSIV
     SLGDLDPQQQ THDRIHTAIY VLLNSLEEVE EALCLPPRVR LAITLQASPR SDGSTSEQEK
     AMSAAFYGGL SAATEGIDDI LTEFGRRVND TKGMLRQHMD L