ID   PHM8_YEAST              Reviewed;         321 AA.
AC   P40025; D3DLT6;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 160.
DE   RecName: Full=Phosphate metabolism protein 8;
GN   Name=PHM8; OrderedLocusNames=YER037W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA   Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA   Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA   Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   PRELIMINARY FUNCTION, AND INDUCTION.
RX   PubMed=11102525; DOI=10.1091/mbc.11.12.4309;
RA   Ogawa N., DeRisi J.L., Brown P.O.;
RT   "New components of a system for phosphate accumulation and polyphosphate
RT   metabolism in Saccharomyces cerevisiae revealed by genomic expression
RT   analysis.";
RL   Mol. Biol. Cell 11:4309-4321(2000).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: May be involved in phosphate metabolism.
CC   -!- INDUCTION: By low phosphate level. {ECO:0000269|PubMed:11102525}.
CC   -!- MISCELLANEOUS: Present with 195 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the SSM1 family. {ECO:0000305}.
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DR   EMBL; U18796; AAB64572.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07690.1; -; Genomic_DNA.
DR   PIR; S50540; S50540.
DR   RefSeq; NP_010954.1; NM_001178928.1.
DR   AlphaFoldDB; P40025; -.
DR   SMR; P40025; -.
DR   BioGRID; 36772; 58.
DR   DIP; DIP-5338N; -.
DR   IntAct; P40025; 3.
DR   STRING; 4932.YER037W; -.
DR   MaxQB; P40025; -.
DR   PaxDb; P40025; -.
DR   PRIDE; P40025; -.
DR   EnsemblFungi; YER037W_mRNA; YER037W; YER037W.
DR   GeneID; 856759; -.
DR   KEGG; sce:YER037W; -.
DR   SGD; S000000839; PHM8.
DR   VEuPathDB; FungiDB:YER037W; -.
DR   eggNOG; KOG3109; Eukaryota.
DR   GeneTree; ENSGT00940000176629; -.
DR   HOGENOM; CLU_059493_0_1_1; -.
DR   InParanoid; P40025; -.
DR   OMA; KQCTKNI; -.
DR   BioCyc; MetaCyc:G3O-30218-MON; -.
DR   BioCyc; YEAST:G3O-30218-MON; -.
DR   BRENDA; 3.1.3.5; 984.
DR   PRO; PR:P40025; -.
DR   Proteomes; UP000002311; Chromosome V.
DR   RNAct; P40025; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0005634; C:nucleus; HDA:SGD.
DR   GO; GO:0052642; F:lysophosphatidic acid phosphatase activity; IDA:SGD.
DR   GO; GO:0008252; F:nucleotidase activity; IDA:SGD.
DR   GO; GO:0016036; P:cellular response to phosphate starvation; IMP:SGD.
DR   GO; GO:0009166; P:nucleotide catabolic process; IMP:SGD.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IBA:GO_Central.
DR   GO; GO:0090549; P:response to carbon starvation; IMP:SGD.
DR   GO; GO:0070328; P:triglyceride homeostasis; IMP:SGD.
DR   CDD; cd02604; HAD_5NT; 1.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006439; HAD-SF_hydro_IA.
DR   InterPro; IPR041492; HAD_2.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR010237; Pyr-5-nucltdase.
DR   Pfam; PF13419; HAD_2; 1.
DR   SFLD; SFLDG01132; C1.5.3:_5'-Nucleotidase_Like; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01509; HAD-SF-IA-v3; 1.
DR   TIGRFAMs; TIGR01993; Pyr-5-nucltdase; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..321
FT                   /note="Phosphate metabolism protein 8"
FT                   /id="PRO_0000202627"
SQ   SEQUENCE   321 AA;  37719 MW;  EAAA9BAFAF312982 CRC64;
     MTIAKDYRTI YRNQIKKQIR LNQEHLQSLT HLGSQINFEV DPPKLPDPDP ARKVFFFDID
     NTLYRKSTKV QLLMQQSLSN FFKYELGFDD DEAERLIESY YQEYGLSVKG LIKNKQIDDV
     LQYNTFIDDS LPLQDYLKPD WKLRELLINL KKKKLGKFDK LWLFTNSYKN HAIRCVKILG
     IADLFDGITY CHYDRPIEEE FICKPDPKFF ETAKLQSGLS SFANAWFIDD NESNVRSALS
     MGMGHVIHLI EDYQYESENI VTKDHKNKQQ FSILKDILEI PLIMDVEVYR PSSIAIKEME
     ELEEEGEAVN WSNQQINVQS S