ID   PHMR_PHANO              Reviewed;         564 AA.
AC   Q0V6Q7;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Phomacin cluster regulator phmR {ECO:0000303|PubMed:31815421};
DE   AltName: Full=Phomacin biosynthesis cluster protein R {ECO:0000303|PubMed:31815421};
GN   Name=phmR {ECO:0000303|PubMed:31815421}; ORFNames=SNOG_00307;
OS   Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS   blotch fungus) (Parastagonospora nodorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC   Parastagonospora.
OX   NCBI_TaxID=321614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX   PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA   Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA   Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA   Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT   "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT   analysis of the wheat pathogen Stagonospora nodorum.";
RL   Plant Cell 19:3347-3368(2007).
RN   [2]
RP   FUNCTION, AND PATHWAY.
RX   PubMed=31815421; DOI=10.1021/acschembio.9b00791;
RA   Li H., Wei H., Hu J., Lacey E., Sobolev A.N., Stubbs K.A., Solomon P.S.,
RA   Chooi Y.H.;
RT   "Genomics-driven discovery of phytotoxic cytochalasans involved in the
RT   virulence of the wheat pathogen Parastagonospora nodorum.";
RL   ACS Chem. Biol. 15:226-233(2020).
CC   -!- FUNCTION: Transcription factor that specifically regulates the
CC       expression of the gene cluster that mediates the biosynthesis of the
CC       mycotoxins phomacins, leucine-derived cytochalasans with potent actin
CC       polymerization-inhibitory activities and monocot-specific
CC       antigerminative activities. {ECO:0000269|PubMed:31815421}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; CH445325; EAT91802.1; -; Genomic_DNA.
DR   RefSeq; XP_001790997.1; XM_001790945.1.
DR   AlphaFoldDB; Q0V6Q7; -.
DR   EnsemblFungi; SNOT_00307; SNOT_00307; SNOG_00307.
DR   GeneID; 5968034; -.
DR   KEGG; pno:SNOG_00307; -.
DR   eggNOG; ENOG502SYRD; Eukaryota.
DR   HOGENOM; CLU_494289_0_0_1; -.
DR   InParanoid; Q0V6Q7; -.
DR   OMA; MLMESSC; -.
DR   OrthoDB; 1576792at2759; -.
DR   Proteomes; UP000001055; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Virulence; Zinc.
FT   CHAIN           1..564
FT                   /note="Phomacin cluster regulator phmR"
FT                   /id="PRO_0000449444"
FT   DNA_BIND        33..64
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          68..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          252..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        259..278
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   564 AA;  61552 MW;  FFADD3A2A8DB6646 CRC64;
     MEGQAQPYPF AAVQRGTEVA PQAPFNFSRR YACDRCRGHK LRCIRDQMTV DSPCQRCRKA
     REKCTIGSST RPVPARLNRS SQGHKLPGAT SSASLTTAAP ALSMPPQQAL AWATGLGDTE
     QGDALHLSSV PWLDMFDSAM LDSACDSNHE LDFADRSSGS GSGSRGAADD QDGPGDGRVH
     TITPTSQGTT AVANPFLPGH EFDFSPRFDM PGEQCNSDFE KDCTGAPVHA HLPADERSHV
     ASVEFMHHPV APIHPPTMAS SHRTHSTASN DSSKDSTTGV RDACIQELNE LSSTLTKDLH
     TVVDCKLASS FLFTRSNKGP DEYLFKTLDG SSSQESAIGR MLQGSEKFLD IMKRFNEPAQ
     SAPPFVGLSL RVDAHDFGLL AEAVDGSKNS SEATQLDRRW RILHSYLERR NESPNPLSFG
     SWLGDNLTYG LARKPDMTAK AAVLLCYTNL LWIYETVFFV ICHTLECSPS LAPAIKLPQT
     VPGLEINGFV LQNHPSLQIK ILTQVSSYML DSVEKALQNM LSDSTFQALL ETVLQQEGLQ
     YSPGEETGMI SVRCLIDKVN KMLD