ID   PHMT1_MYCUA             Reviewed;         271 AA.
AC   A0PQX0;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase 1;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MUL_2377;
OS   Mycobacterium ulcerans (strain Agy99).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=362242;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Agy99;
RX   PubMed=17210928; DOI=10.1101/gr.5942807;
RA   Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T.,
RA   Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J.,
RA   Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M.,
RA   Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.;
RT   "Reductive evolution and niche adaptation inferred from the genome of
RT   Mycobacterium ulcerans, the causative agent of Buruli ulcer.";
RL   Genome Res. 17:192-200(2007).
CC   -!- FUNCTION: Catalyzes the methylation of the lipid moiety of the
CC       intermediate compounds phthiotriol and glycosylated phenolphthiotriol
CC       dimycoserosates to form phthiocerol dimycocerosates (DIM A) and
CC       glycosylated phenolphthiocerol dimycocerosates (PGL). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000325; ABL04739.1; -; Genomic_DNA.
DR   RefSeq; WP_011740355.1; NC_008611.1.
DR   AlphaFoldDB; A0PQX0; -.
DR   SMR; A0PQX0; -.
DR   STRING; 362242.MUL_2377; -.
DR   EnsemblBacteria; ABL04739; ABL04739; MUL_2377.
DR   KEGG; mul:MUL_2377; -.
DR   eggNOG; COG2226; Bacteria.
DR   HOGENOM; CLU_068661_0_0_11; -.
DR   OMA; EWILRAH; -.
DR   Proteomes; UP000000765; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis; Lipid metabolism; Methyltransferase; Transferase.
FT   CHAIN           1..271
FT                   /note="Phthiotriol/phenolphthiotriol dimycocerosates
FT                   methyltransferase 1"
FT                   /id="PRO_0000305167"
SQ   SEQUENCE   271 AA;  30917 MW;  82E8371599616E7A CRC64;
     MAFSPAHRLL ARLGSTSIYK RVWRYWYPLM TRGLGADKIA FLNWAYEEDP PIDLTLEVSD
     EPNRDHINMY HRTATHVELS GKRVLEVSCG HGGGASYLTR TLHPASYTGL DLNRAGIKLC
     QRRHNLPGLD FVRGDAENLP FEDESFDVVL KVEASHCYPH FSRFLAEVVR VLRPGGYLLY
     TDLRPSNEIA EWEADLAGSP LRQLSQREIN AEVVRGIEKN SHTSRVLVDR NLPAFLRFAD
     RAVGRQLSRY LEGGELSYRM YCFTKDFAAS R